Browsing by Author "Ferran, Christiane"

Now showing items 1-6 of 6

    • A20 deficiency causes spontaneous neuroinflammation in mice 

      Guedes, Renata Padilha; Csizmadia, Eva; Moll, Herwig P; Ma, Averil; Ferran, Christiane; da Silva, Cleide Gonçalves (BioMed Central, 2014)
      Background: A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. ...

    • A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration 

      Studer, Peter; Longo, Christopher R.; Csizmadia, Eva; Shrikhande, Gautam V.; Scali, Salvatore T.; Bhasin, Manoj K.; Selvarajoo, Kumar; Damrauer, Scott Michael; Da Silva, Cleide Gonsalves; Ramsey, Haley Elizabeth; Libermann, Towia Aron; Ferran, Christiane (Public Library of Science, 2011)
      Background: Liver Regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-\(\kappa\)B inhibitory protein A20 significantly improves ...

    • Induction of Protective Genes Leads to Islet Survival and Function 

      Wang, Hongjun; Ferran, Christiane; Attanasio, Chiara; Calise, Fulvio; Otterbein, Leo E. (Hindawi Publishing Corporation, 2011)
      Islet transplantation is the most valid approach to the treatment of type 1 diabetes. However, the function of transplanted islets is often compromised since a large number of β cells undergo apoptosis induced by stress ...

    • Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea 

      Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)
      Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ...

    • O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice 

      Shrikhande, Gautam V.; Scali, Salvatore T.; Csizmadia, Eva; Matthey, Michaela; Arjoon, Roy; Patel, Rakesh; Maccariello, Elizabeth R.; Andersen, Nicholas D.; Monahan, Thomas; Studer, Peter; Padilha Guedes, Renata; Usheva, Anny; Da Silva, Cleide Gonsalves; Damrauer, Scott Michael; Putheti, Prabhakar; Siracuse, Jeffrey Joseph; Peterson, Clayton Ross; Essayagh, Sanah; Kocher, Olivier Nicolas; Veves, Aristidis; Kaczmarek, Elzbieta; Ferran, Christiane (Public Library of Science, 2010)
      Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ...

    • Temporal Network Based Analysis of Cell Specific Vein Graft Transcriptome Defines Key Pathways and Hub Genes in Implantation Injury 

      Bhasin, Manoj; Pradhan-Nabzdyk, Leena; LoGerfo, Philip J.; Guthrie, Patrick; Csizmadia, Eva; Andersen, Nicholas; Huang, Zhen S.; Malek, Junaid Yusuf; Contreras, Mauricio Antonio; Kocher, Olivier Nicolas; Ferran, Christiane; Logerfo, Frank W. (Public Library of Science, 2012)
      Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft ...