Now showing items 1-20 of 40

    • Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia 

      Shenton, Martha Elizabeth; Kikinis, Ron; Jolesz, Ferenc A.; Pollak, Seth D.; Lemay, Marjorie Jeannette; Wible, Cynthia Gayle; Hokama, Hiroto; Martin, John; Metcalf, Dave; Coleman, Michael James; McCarley, Robert William (New England Journal of Medicine (NEJM/MMS), 1992)
      BACKGROUND: Data from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these ...
    • Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors 

      Eberlin, L. S.; Norton, I.; Orringer, D.; Dunn, Ian Frederick; Liu, X.; Ide, J. L.; Jarmusch, A. K.; Ligon, Keith Lloyd; Jolesz, Ferenc A.; Golby, Alexandra Jacqueline; Santagata, Sandro; Agar, Nathalie Marie Yvonne Rachel; Cooks, R. G. (Proceedings of the National Academy of Sciences, 2013)
      The main goal of brain tumor surgery is to maximize tumor resection while preserving brain function. However, existing imaging and surgical techniques do not offer the molecular information needed to delineate tumor ...
    • Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study 

      Kasai, Kiyoto; McCarley, Robert William; Salisbury, Dean F.; Onitsuka, Toshiaki; Demeo, Susan; Yurgelun-Todd, Deborah; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (Elsevier BV, 2004)
      A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical ...
    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...
    • Comparison of Single-Shot Echo-Planar and Line Scan Protocols for Diffusion Tensor Imaging 

      Kubicki, Marek R.; Maier, Stephan Ernst; Westin, Carl-Fredrik; Mamata, Hatsuho; Ersner-Hershfield, Hal; Estepar, Raul; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier, 2004)
      Rationale and Objectives: Both single-shot diffusion-weighted echo-planar imaging (EPI) and line scan diffusion imaging (LSDI) can be used to obtain magnetic resonance diffusion tensor data and to calculate directionally ...
    • Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery 

      Agar, Nathalie Marie Yvonne Rachel; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Norton, Isaiah Hakim; Mohan, Vandana; Wiseman, Justin M; Tannenbaum, Allen; Jolesz, Ferenc A. (Oxford University Press (OUP), 2011)
      BACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. ...
    • Diffusion Tensor Imaging and Its Application to Neuropsychiatric Disorders 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Maier, Stephan Ernst; Mamata, Hatsuho; Frumin, Melissa; Ersner-Hershfield, Hal; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. ...
    • A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia 

      Levitt, James Jonathan; Kubicki, Marek R.; Nestor, Paul Gerard; Ersner-Hershfield, Hal; Westin, C-F; Alvarado, Jorge L.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal ...
    • DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 

      Kubicki, Marek R.; Park, H.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Mulkern, Robert Vincent; Maier, Stephan Ernst; Niznikiewicz, Margaret A.; Connor, E.E.; Levitt, James Jonathan; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ...
    • Extended Broca’s Area in the Functional Connectome of Language in Adults: Combined Cortical and Subcortical Single-Subject Analysis Using fMRI and DTI Tractography 

      Lemaire, Jean-Jacques; Golby, Alexandra Jacqueline; Wells, William Mercer; Pujol, Sonia; Tie, Yanmei; Rigolo, Laura; Yarmarkovich, Alexander; Pieper, Steve; Westin, Carl-Fredrik; Jolesz, Ferenc A.; Kikinis, Ron (Springer Nature, 2012)
      Traditional models of the human language circuitry encompass three cortical areas, Broca’s, Geschwind’s and Wernicke’s, and their connectivity through white matter fascicles. The neural connectivity deep to these cortical ...
    • A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia 

      Wible, Cynthia Gayle; Kubicki, Marek R.; Yoo, Seung-Schik; Kacher, Daniel F.; Salisbury, Dean F.; Anderson, Mark Allen; Shenton, Martha Elizabeth; Hirayasu, Yoshio; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (American Psychiatric Publishing, 2001)
      Objective: Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to ...
    • High-Resolution Line Scan Diffusion Tensor MR Imaging of White Matter Fiber Tract Anatomy 

      Mamata, Hatsuho; Mamata, Yoshiaki; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Kikinis, Ron; Jolesz, Ferenc A.; Maier, Stephan Ernst (2002)
      Background and Purpose: MR diffusion tensor imaging permits detailed visualization of white matter fiber tracts. This technique, unlike T2-weighted imaging, also provides information about fiber direction. We present ...
    • An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis 

      Wiegand, Laura C.; Warfield, Simon Keith; Levitt, James Jonathan; Hirayasu, Yoshio; Salisbury, Dean F.; Heckers, Stephan; Bouix, Sylvain; Schwartz, Daniel; Spencer, Magdalena; Dickey, Chandlee C.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2005)
      Objective: The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia. ...
    • Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder 

      Gurvits, Tamara V.; Shenton, Martha Elizabeth; Hokama, Hiroto; Ohta, Hirokazu; Lasko, Natasha B.; Gilbertson, Mark; Orr, Scott P.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Pitman, roger Keith (Elsevier BV, 1996)
      This study used quantitative volumetric magnetic resonance imaging techniques to explore the neuroanatomic correlates of chronic, combat-related posttraumatic stress disorder (PTSD) in seven Vietnam veterans with PTSD ...
    • Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in Chronic Schizophrenia: An MRI Study 

      Onitsuka, Toshiaki; Shenton, Martha Elizabeth; Salisbury, Dean F.; Dickey, Chandlee C.; Kasai, Kiyoto; Toner, Sarah K.; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (American Psychiatric Publishing, 2004)
      Objective: The middle temporal gyrus and inferior temporal gyrus subserve language and semantic memory processing, visual perception, and multimodal sensory integration. Functional deficits in these cognitive processes ...
    • Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia: An MRI Study 

      Kuroki, Noriomi; Shenton, Martha Elizabeth; Salisbury, Dean; Hirayasu, Yoshio; Onitsuka, Toshiaki; Ersner-Hershfield, Hal; Yurgelun-Todd, Deborah; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (American Psychiatric Publishing, 2006)
      Objective: Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior temporal gyrus and the amygdala-hippocampal complex. However, the middle and inferior ...
    • Monitoring and visualization techniques for MR-guided laser ablations in an open MR system 

      Kettenbach, Joachim; Silverman, Stuart George; Hata, Nobuhiko; Kuroda, Kagayaki; Saiviroonporn, Pairash; Zientara, Gary Peter; Morrison, Paul T; Hushek, Stephen G.; Black, Peter McLaren; Kikinis, Ron; Jolesz, Ferenc A. (Wiley-Blackwell, 1998)
      Our purpose was to develop temperature sensitive MR sequences and image-processing techniques to asses their potential of monitoring interstitial laser therapy (ILT) in brain tumors (n = 3) and liver tumors (n = 7). ILT ...
    • MRI Study of Caudate Nucleus Volume and Its Cognitive Correlates in Neuroleptic-Naive Patients With Schizotypal Personality Disorder 

      Levitt, James Jonathan; McCarley, Robert William; Dickey, Chandlee C.; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Hirayasu, Yoshio; Ciszewski, Aleksandra A.; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2002)
      Objective: “Cognitive” circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of the core components of these circuits, such as in the caudate nucleus, may result in neurobehavioral ...
    • MRI Study of Cavum Septi Pellucidi in Schizophrenia, Affective Disorder, and Schizotypal Personality Disorder 

      Kwon, Jun Soo; Shenton, Martha Elizabeth; Hirayasu, Yoshio; Salisbury, Dean F.; Fischer, Iris A.; Dickey, Chandlee C.; Yurgelun-Todd, Deborah; Tohen, Mauricio; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (American Psychiatric Publishing, 1998)
      Objective: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of the brain. The authors examined cavum septi pellucidi in subjects with schizophrenia, affective disorder, and ...
    • An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controls 

      Park, Hae-Jeong; Levitt, James Jonathan; Shenton, Martha Elizabeth; Salisbury, Dean F; Kubicki, Marek R.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (Elsevier BV, 2004)
      We created a spatial probability atlas of schizophrenia to provide information about the neuroanatomic variability of brain regions of patients with the disorder. Probability maps of 16 regions of interest (ROIs) were ...