Now showing items 1-3 of 3

    • “cAMP Sponge”: A Buffer for Cyclic Adenosine 3′, 5′-Monophosphate 

      Lefkimmiatis, Konstantinos; Moyer, Mary Pat; Curci, Silvana Maria Immacolata; Hofer, Aldebaran (Public Library of Science, 2009)
      Background: While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP). Methods/Principal Findings: Here we describe a genetically ...
    • The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics 

      Lefkimmiatis, Konstantinos; Leronni, Daniela; Hofer, Aldebaran M. (The Rockefeller University Press, 2013)
      Cyclic AMP (cAMP)-dependent phosphorylation has been reported to exert biological effects in both the mitochondrial matrix and outer mitochondrial membrane (OMM). However, the kinetics, targets, and effectors of the cAMP ...
    • Recent advances in understanding the extracellular calcium-sensing receptor 

      Colella, Matilde; Gerbino, Andrea; Hofer, Aldebaran M.; Curci, Silvana (F1000Research, 2016)
      The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca ...