Now showing items 1-20 of 85

    • Ambient air pollution, lung function, and airway responsiveness in asthmatic children 

      Ierodiakonou, Despo; Zanobetti, Antonella; Coull, Brent Andrew; Melly, Steven John; Postma, Dirkje S.; Boezen, H. Marike; Vonk, Judith M.; Williams, Paul V.; Shapiro, Gail G.; McKone, Edward F.; Hallstrand, Teal S.; Koenig, Jane Q.; Schildcrout, Jonathan S.; Lumley, Thomas; Fuhlbrigge, Anne Louise; Koutrakis, Petros; Schwartz, Joel David; Weiss, Scott Tillman; Gold, Diane R. (Elsevier BV, 2016)
      Background: Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthma are lacking. Objective: To investigate pollution effects in ...
    • Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort 

      Chipps, Bradley E.; Zeiger, Robert S.; Dorenbaum, Alejandro; Borish, Larry; Wenzel, Sally E.; Miller, Dave P.; Hayden, Mary Lou; Bleecker, Eugene R.; Simons, F. Estelle R.; Szefler, Stanley J.; Weiss, Scott Tillman; Haselkorn, Tmirah (Current Science Inc., 2012)
      Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, ...
    • Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. 

      Wright, Robert O.; Silverman, Edwin Kepner; Schwartz, Joel David; Tsaih, Shring-Wern; Senter, Jody; Sparrow, David; Weiss, Scott Tillman; Aro, Antonio; Hu, Howard (2004)
      Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...
    • The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts 

      Emilsson, Valur; Hinney, Anke; Heid, Iris M; Zhu, Xiaofeng; Thorleifsson, Gudmar; Gunnarsdottir, Steinunn; Walters, G. Bragi; Thorsteinsdottir, Unnur; Kong, Augustine; Gulcher, Jeffrey; Nguyen, Thuy Trang; Scherag, André; Pfeufer, Arne; Meitinger, Thomas; Brönner, Günter; Rief, Winfried; Soto-Quiros, Manuel E; Avila, Lydiana; Groop, Leif; Tuomi, Tiinamaija; Isomaa, Bo; Bengtsson, Kristina; Butler, Johannah L; Vollmert, Caren; Celedón, Juan C; Wichmann, H. Erich; Hebebrand, Johannes; Stefansson, Kari; Abecasis, Gonçalo; Lyon, Helen N; Su, Jessica Ann Lasky; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman; Laird, Nan M.; Ding, Xiao; Cooper, Richard S; Fox, Caroline; O'Donnell, Christopher Joseph; Lange, Christoph; Hirschhorn, Joel Naom (Public Library of Science, 2007)
      A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the ...
    • Asthma and Genes Encoding Components of the Vitamin D Pathway 

      Bossé, Yohan; Lemire, Mathieu; Poon, Audrey H; Daley, Denise; He, Jian-Qing; Sandford, Andrew; James, Alan L; Musk, Arthur William; Palmer, Lyle J; Kozyrskyj, Anita L; Becker, Allan; Hudson, Thomas J; Laprise, Catherine; White, John H.; Raby, Benjamin Alexander; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy. ...
    • Asthma-susceptibility variants identified using probands in case-control and family-based analyses 

      Murphy, Amy J; Soto-Quiros, Manuel E; Avila, Lydiana; Celedón, Juan C; O'Connor, George T; Himes, Blanca Elena; Su, Jessica Ann Lasky; Wu, Ann Chen; Wilk, Jemma B; Hunninghake, Gary Matthew; Klanderman, Barbara Jordan; Lazarus, Ross; Lange, Christoph; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman (BioMed Central, 2010)
      Background: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ...
    • Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop 

      Bousquet, Jean; Gern, James E.; Martinez, Fernando D.; Anto, Josep M.; Johnson, Christine Haynes; Holt, Patrick G.; Lemanske, Robert F.; Le Souëf, Peter N.; Tepper, Robert Ira; von Mutius, Erika R.M.; Arshad, S. Hasan; Bacharier, Leonard B.; Becker, Allan; Belanger, Kathleen; Bergström, Anna; Bernstein, David I.; Cabana, Michael D.; Carroll, Kecia N.; Castro, Mario; Cooper, Philip J.; Gillman, Matthew William; Gold, Diane R.; Henderson, John; Heinrich, Joachim; Hong, Soo-Jong; Jackson, Danielle; Keil, Thomas; Kozyrskyj, Anita L.; Lødrup Carlsen, Karin C.; Miller, Rachel Blair; Momas, Isabelle; Morgan, Wayne J.; Noel, Patricia; Ownby, Dennis R.; Pinart, Mariona; Ryan, Patrick H.; Schwaninger, Julie M.; Sears, Malcolm R.; Simpson, Angela; Smit, Henriette A.; Stern, Debra A.; Subbarao, Padmaja; Valenta, Rudolf; Wang, Xiaobin; Weiss, Scott Tillman; Wood, Robert J.; Wright, Anne L.; Wright, Rosalind Jo; Togias, Alkis; Gergen, Peter J. (Elsevier BV, 2014)
      Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. Over 130 birth cohorts focusing on asthma and allergy have been initiated ...
    • A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research 

      Yeatts, Karin; Sly, Peter; Martinez, Fernando; Geller, Andrew; Bromberg, Philip; Enright, Paul; Koren, Hillel; Weissman, David; Selgrade, MaryJane; Shore, Stephanie; Weiss, Scott Tillman (National Institute of Environmental Health Sciences, 2006)
      Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better ...
    • CD11a polymorphisms regulate TH2 cell homing and TH2-related disease 

      Knight, John R.; Lee, Seung-Hyo; Roberts, Luz; Smith, C. Wayne; Weiss, Scott Tillman; Kheradmand, Farrah; Corry, David B. (Elsevier BV, 2014)
      Background: TH2-dependent diseases vary in severity according to genotype, but relevant gene polymorphisms remain largely unknown. The integrin CD11a is a critical determinant of allergic responses, and allelic variants ...
    • CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data 

      McGeachie, Michael J.; Chang, Hsun-Hsien; Weiss, Scott T. (Public Library of Science, 2014)
      Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous ...
    • Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses 

      Tantisira, Kelan; Weiss, Scott Tillman (BioMed Central, 2001)
      The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 ...
    • Circulating MicroRNAs: Association with Lung Function in Asthma 

      Kho, Alvin T.; Sharma, Sunita; Davis, Joshua S.; Spina, Joseph; Howard, Dagnie; McEnroy, Kevin; Moore, Kip; Sylvia, Jody; Qiu, Weiliang; Weiss, Scott T.; Tantisira, Kelan G. (Public Library of Science, 2016)
      Background: MicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated. Objective: We hypothesized ...
    • Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications 

      Howrylak, Judie A.; Fuhlbrigge, Anne Louise; Strunk, Robert C.; Zeiger, Robert S.; Weiss, Scott Tillman; Raby, Benjamin Alexander (Elsevier BV, 2014)
      Background— Although recent studies have identified the presence of phenotypic clusters in asthmatic patients, the clinical significance and temporal stability of these clusters have not been explored. Objective— Our ...
    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...
    • Common ADRB2 Haplotypes Derived from 26 Polymorphic Sites Direct β2-Adrenergic Receptor Expression and Regulation Phenotypes 

      Panebra, Alfredo; Wang, Wayne C.; Malone, Molly M.; Pitter, Demar R. G.; Weiss, Scott Tillman; Hawkins, Gregory A.; Liggett, Stephen B. (Public Library of Science, 2010)
      Background: The β2-adrenergic receptor (β2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes. Drugs (agonists or antagonists) acting at these receptors for treatment of asthma, ...
    • A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data 

      Li, Xuan; Qiu, Weiliang; Morrow, Jarrett; DeMeo, Dawn L.; Weiss, Scott T.; Fu, Yuejiao; Wang, Xiaogang (Public Library of Science, 2015)
      Variable DNA methylation has been associated with cancers and complex diseases. Researchers have identified many DNA methylation markers that have different mean methylation levels between diseased subjects and normal ...
    • Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D 

      Tse, Szewah; Rolls, Hillary R; Litonjua, Augusto Ampil; Van Natta, Mark L.; Weiss, Scott Tillman; Tantisira, Kelan G. (Elsevier BV, 2012)
      Background— The adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been associated with decreased ...
    • Delivery by caesarean section and risk of obesity in preschool age children: A prospective cohort study 

      Huh, Susanna; Rifas-Shiman, Sheryl Lynn; Zera, Chloe Amelia; Edwards, Janet W. Rich; Oken, Emily; Weiss, Scott Tillman; Gillman, Matthew William (BMJ, 2012)
      Objective: To examine whether delivery by caesarean section is a risk factor for childhood obesity. Design: Prospective pre-birth cohort study (Project Viva). Setting: Eight outpatient multi-specialty practices based ...
    • A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study. 

      Wu, Ming-Tsang; Kelsey, Karl; Schwartz, Joel David; Sparrow, David; Weiss, Scott Tillman; Hu, Howard (2003)
      In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function ...