Browsing by Author "Murphy, Michael"
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Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
Wang, Jing; Alt, Frederick W.; Gostissa, Monica; Datta, Abhishek; Murphy, Michael C.; Alimzhanov, Marat B.; Coakley, Kristen M.; Rajewsky, Klaus; Manis, John P.; Yan, Catherine T. (The Rockefeller University Press, 2008)Nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks (DSBs) during V(D)J recombination in developing lymphocytes and during immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) in peripheral ... -
Polζ Ablation in B Cells Impairs the Germinal Center Reaction, Class Switch Recombination, DNA Break Repair, and Genome Stability
Schenten, Dominik; Kracker, Sven; Esposito, Gloria; Franco, Sonia; Klein, Ulf; Murphy, Michael C.; Alt, Frederick W.; Rajewsky, Klaus (Rockefeller University Press, 2009)Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand ...