Now showing items 1-3 of 3

    • Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis 

      Giuliano, Mario; Herrera, Sabrina; Christiny, Pavel; Shaw, Chad; Creighton, Chad J; Mitchell, Tamika; Bhat, Raksha; Zhang, Xiaomei; Mao, Sufeng; Dobrolecki, Lacey E; Al-rawi, Ahmed; Chen, Fengju; Veneziani, Bianca M; Zhang, Xiang H-F; Hilsenbeck, Susan G; Contreras, Alejandro; Gutierrez, Carolina; Jeselsohn, Rinath M; Rimawi, Mothaffar F; Osborne, C Kent; Lewis, Michael T; Schiff, Rachel; Trivedi, Meghana V (BioMed Central, 2015)
      Introduction: Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, ...
    • Digital Quantification of Gene Expression in Sequential Breast Cancer Biopsies Reveals Activation of an Immune Response 

      Jeselsohn, Rinath M.; Werner, Lillian; Regan, Meredith M.; Fatima, Aquila; Gilmore, Lauren; Collins, Laura C.; Beck, Andrew H.; Bailey, Shannon T.; He, Housheng Hansen; Buchwalter, Gilles; Brown, Myles; Iglehart, J. Dirk; Richardson, Andrea; Come, Steven E. (Public Library of Science, 2013)
      Advancements in molecular biology have unveiled multiple breast cancer promoting pathways and potential therapeutic targets. Large randomized clinical trials remain the ultimate means of validating therapeutic efficacy, ...
    • How drug resistance takes shape 

      Jeselsohn, Rinath; Brown, Myles (eLife Sciences Publications, Ltd, 2016)
      Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.