Browsing by Author "Sparrow, David"

Now showing items 1-20 of 28

    • Accumulated Lead Exposure and Risk of Age-Related Cataract in Men 

      Schaumberg, Debra Ann; Mendes, Flavia; Balaram, Mini; Dana, Reza; Sparrow, David; Hu, Howard (American Medical Association (AMA), 2004)
      Context Low-level lead exposure may increase the risk for a number of chronic age-related diseases. Several studies have documented the presence of lead in lenses with cataract. The intrusion of lead into the lens may alter ...

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...

    • Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. 

      Wright, Robert O.; Silverman, Edwin Kepner; Schwartz, Joel David; Tsaih, Shring-Wern; Senter, Jody; Sparrow, David; Weiss, Scott Tillman; Aro, Antonio; Hu, Howard (2004)
      Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...

    • Associations between air pollution and perceived stress: the Veterans Administration Normative Aging Study 

      Mehta, Amar J; Kubzansky, Laura D; Coull, Brent A; Kloog, Itai; Koutrakis, Petros; Sparrow, David; Spiro, Avron; Vokonas, Pantel; Schwartz, Joel (BioMed Central, 2015)
      Background: There is mixed evidence suggesting that air pollution may be associated with increased risk of developing psychiatric disorders. We aimed to investigate the association between air pollution and non-specific ...

    • Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study 

      Mehta, Amar J.; Kloog, Itai; Zanobetti, Antonella; Coull, Brent A.; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)
      Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily ...

    • Associations between outdoor temperature and markers of inflammation: a cohort study 

      Halonen, Jaana I; Zanobetti, Antonella; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (BioMed Central, 2010)
      Background: Associations between ambient temperature and cardiovascular mortality are well established. This study investigated whether inflammation could be part of the mechanism leading to temperature-related cardiovascular ...

    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...

    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...

    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...

    • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

      Perlstein, Todd Steven; Weuve, Jennifer Lynn; Schwartz, Joel David; Sparrow, David; Wright, Robert O.; Litonjua, Augusto Ampil; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...

    • Cumulative Lead Exposure and Tooth Loss in Men: The Normative Aging Study 

      Arora, Manish; Weuve, Jennifer Lynn; Weisskopf, Marc G.; Sparrow, David; Nie, Huiling; Garcia, Raul I.; Hu, Howard (National Institute of Environmental Health Sciences, 2009)
      Background: Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor ...

    • A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study. 

      Wu, Ming-Tsang; Kelsey, Karl; Schwartz, Joel David; Sparrow, David; Weiss, Scott Tillman; Hu, Howard (2003)
      In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function ...

    • Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area 

      Lin, Charles; Kim, Rokho; Tsaih, Shirng-Wern; Sparrow, David; Hu, Howard (National Institue of Environmental Health Sciences, 2004)
      We measured blood and bone lead levels among minority individuals who live in some of Boston’s neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, ...

    • Effects of air pollution on heart rate variability: the VA Normative Aging Study 

      O’Neill, Marie S.; Park, Sung Kyun; Vokonas, Pantel S; Sparrow, David; Schwartz, Joel David (National Institue of Environmental Health Sciences, 2004)
      Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM\(_{2.5}\))]. We examined ...

    • Folliculin Mutations Are Not Associated with Severe COPD 

      Cho, Michael Hyosang; Klanderman, Barbara Jordan; Litonjua, Augusto Ampil; Sparrow, David; Silverman, Edwin Kepner; Raby, Benjamin Alexander (BioMed Central, 2008)
      Background: Rare loss-of-function folliculin (FLCN) mutations are the genetic cause of Birt-Hogg-Dubé syndrome, a monogenic disorder characterized by spontaneous pneumothorax, fibrofolliculomas, and kidney tumors. ...

    • HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the normative aging study 

      Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010)
      Background: Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...

    • Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval 

      Park, Sung Kyun; Hu, Howard; Wright, Robert O.; Schwartz, Joel David; Cheng, Yawen; Sparrow, David; Vokonas, Pantel S; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2008)
      Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...

    • Lead Concentrations in Relation to Multiple Biomarkers of Cardiovascular Disease: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; Ikeda, Ai; Fang, Shona C.; Sparrow, David; Weisskopf, Marc G.; Wright, Robert O.; Vokonas, Pantel S; Hu, Howard; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between ...

    • Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study 

      Jain, Nitin; Potula, Vijayalakshmi; Schwartz, Joel David; Vokonas, Pantel S; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...

    • Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study 

      Tsaih, Shirng-Wern; Korrick, Susan Abigail; Schwartz, Joel David; Amarasiriwardena, Chitra J.; Aro, Antonio; Sparrow, David; Hu, Howard (National Institue of Environmental Health Sciences, 2004)
      In this prospective study, we examined changes in renal function during 6 years of follow-up in relation to baseline lead levels, diabetes, and hypertension among 448 middle-age and elderly men, a subsample of the Normative ...