Browsing by Author "Li, Shaomin"
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The biomarkers of immune dysregulation and inflammation response in Parkinson disease
Chen, Li; Mo, Mingshu; Li, Guangning; Cen, Luan; Wei, Lei; Xiao, Yousheng; Chen, Xiang; Li, Shaomin; Yang, Xinling; Qu, Shaogang; Xu, Pingyi (BioMed Central, 2016)Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility ... -
Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction
Zhang, Limin; Cen, Luan; Qu, Shaogang; Wei, Lei; Mo, Mingshu; Feng, Junmin; Sun, Congcong; Xiao, Yousheng; Luo, Qin; Li, Shaomin; Yang, Xinling; Xu, Pingyi (Public Library of Science, 2016)Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor ... -
Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity
Welzel, Alfred T.; Maggio, John E.; Shankar, Ganesh M.; Walker, Donald E.; Ostaszewski, Beth L.; Li, Shaomin; Klyubin, Igor; Rowan, Michael J.; Seubert, Peter; Walsh, Dominic M.; Selkoe, Dennis J. (American Chemical Society, 2014)Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of ...