Browsing by Author "Mar, Jessica Cara"
Now showing items 1-5 of 5
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Bayesian and Maximum Likelihood Phylogenetic Analyses of Protein Sequence Data Under Relative Branch-Length Differences and Model Violation
Mar, Jessica Cara; Harlow, Timothy J; Ragan, Mark A (BioMed Central, 2005)Background: Bayesian phylogenetic inference holds promise as an alternative to maximum likelihood, particularly for large molecular-sequence data sets. We have investigated the performance of Bayesian inference with empirical ... -
Data-Driven Normalization Strategies for High-Throughput Quantitative RT-PCR
Mar, Jessica Cara; Kimura, Yasumasa; Schroder, Kate; Irvine, Katharine M; Hayashizaki, Yoshihide; Suzuki, Harukazu; Hume, David; Quackenbush, John (BioMed Central, 2009)Background: High-throughput real-time quantitative reverse transcriptase polymerase chain reaction (qPCR) is a widely used technique in experiments where expression patterns of genes are to be profiled. Current stage ... -
Decomposition of Gene Expression State Space Trajectories
Mar, Jessica Cara; Quackenbush, John (Public Library of Science, 2009)Representing and analyzing complex networks remains a roadblock to creating dynamic network models of biological processes and pathways. The study of cell fate transitions can reveal much about the transcriptional regulatory ... -
Inferring steady state single-cell gene expression distributions from analysis of mesoscopic samples
Mar, Jessica Cara; Rubio, Renee; Quackenbush, John (BioMed Central, 2006)Background: A great deal of interest has been generated by systems biology approaches that attempt to develop quantitative, predictive models of cellular processes. However, the starting point for all cellular gene ... -
Therapeutic Implications of GIPC1 Silencing in Cancer
Chittenden, Thomas W.; Pak, Jane; Rubio, Renee; Holton, Kristina; Prendergast, Niall; Glinskii, Vladimir; Schwede, Mathew; Howe, Eleanor A.; Aryee, Martin; Sultana, Razvan; Lanahan, Anthony A.; Holmes, Chris; Cheng, Hailing; Cai, Yi; Culhane, Aedin; Bentink, Stefan; Mar, Jessica Cara; Taylor, Jennifer; Hahn, William C.; Zhao, Jean J.; Iglehart, James Dirk; Quackenbush, John (Public Library of Science, 2010)GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human ...