Now showing items 1-8 of 8

    • Clinical significance of T cell metabolic reprogramming in cancer 

      Herbel, Christoph; Patsoukis, Nikolaos; Bardhan, Kankana; Seth, Pankaj; Weaver, Jessica D.; Boussiotis, Vassiliki A. (Springer Berlin Heidelberg, 2016)
      Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known as Warburg ...
    • Erratum to: Modeling precision treatment of breast cancer 

      Daemen, Anneleen; Griffith, Obi L; Heiser, Laura M; Wang, Nicholas J; Enache, Oana M; Sanborn, Zachary; Pepin, Francois; Durinck, Steffen; Korkola, James E; Griffith, Malachi; Hur, Joe S; Huh, Nam; Chung, Jongsuk; Cope, Leslie; Fackler, Mary Jo; Umbricht, Christopher; Sukumar, Saraswati; Seth, Pankaj; Sukhatme, Vikas P; Jakkula, Lakshmi R; Lu, Yiling; Mills, Gordon B; Cho, Raymond J; Collisson, Eric A; van’t Veer, Laura J; Spellman, Paul T; Gray, Joe W (BioMed Central, 2015)
      During the type-setting of the final version of the article [1] some of the additional files were swapped. The correct files are republished in this Erratum. The online version of the original article can be found under ...
    • Heme oxygenase-1 in macrophages controls prostate cancer progression 

      Nemeth, Zsuzsanna; Li, Mailin; Csizmadia, Eva; Döme, Balazs; Johansson, Martin; Persson, Jenny Liao; Seth, Pankaj; Otterbein, Leo; Wegiel, Barbara (Impact Journals LLC, 2015)
      Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the ...
    • Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2 

      Everett, Peter; Clish, Clary B.; Polymenis, Michael; Ren, Jian-Guo; Seth, Pankaj; Sukhatme, Vikas Pandurang (Public Library of Science, 2010)
      Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. ...
    • Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling 

      Ren, Jian-Guo; Seth, Pankaj; Clish, Clary B.; Lorkiewicz, Pawel K.; Higashi, Richard M.; Lane, Andrew N.; Fan, Teresa W.-M.; Sukhatme, Vikas P. (Nature Publishing Group, 2014)
      Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of malate to yield CO2 and pyruvate, with concomitant reduction of dinucleotide cofactor NAD+ or NADP+. We find that ME2 is highly expressed in ...
    • Modeling precision treatment of breast cancer 

      Daemen, Anneleen; Griffith, Obi L; Heiser, Laura M; Wang, Nicholas J; Enache, Oana M; Sanborn, Zachary; Pepin, Francois; Durinck, Steffen; Korkola, James E; Griffith, Malachi; Hur, Joe S; Huh, Nam; Chung, Jongsuk; Cope, Leslie; Fackler, Mary Jo; Umbricht, Christopher; Sukumar, Saraswati; Seth, Pankaj; Sukhatme, Vikas P; Jakkula, Lakshmi R; Lu, Yiling; Mills, Gordon B; Cho, Raymond J; Collisson, Eric A; van’t Veer, Laura J; Spellman, Paul T; Gray, Joe W (BioMed Central, 2013)
      Background: First-generation molecular profiles for human breast cancers have enabled the identification of features that can predict therapeutic response; however, little is known about how the various data types can best ...
    • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation 

      Patsoukis, Nikolaos; Bardhan, Kankana; Chatterjee, Pranam; Sari, Duygu; Liu, Bianling; Bell, Lauren N.; Karoly, Edward D.; Freeman, Gordon J.; Petkova, Victoria; Seth, Pankaj; Li, Lequn; Boussiotis, Vassiliki A. (Nature Pub. Group, 2015)
      During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but ...
    • Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology 

      Husain, Zaheed; Seth, Pankaj; Sukhatme, Vikas P (Landes Bioscience, 2013)
      Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of ...