Now showing items 1-2 of 2

    • Microbial Bile Acid Metabolites Modulate Gut RORγ+ Regulatory T Cell Homeostasis 

      Song, Xinyang; Sun, Ximei; Oh, Sungwhan F.; Wu, Meng; Zhang, Yanbo; Zheng, Wen; Geva Zatorsky, Naama; Jupp, Ray; Mathis, Diane; Benoist, Christophe; Kasper, Dennis (Springer Science and Business Media LLC, 2020-01-16)
      The metabolic pathways encoded by the human gut microbiome constantly interact with host gene products through numerous bioactive molecules1. Primary bile acids (BAs) are synthesized within hepatocytes and released into ...
    • Microbiota-Targeted Maternal Antibodies Protect Neonates From Enteric Infection 

      Zheng, Wen; Zhao, Wenjing; Wu, Meng; Song, Xinyang; Caro, Florence; Sun, Ximei; Gazzaniga, Francesca; Stefanetti, Giuseppe; Oh, Sungwhan; Mekalanos, John; Kasper, Dennis (Springer Science and Business Media LLC, 2020-01-23)
      Although maternal antibodies protect newborns from infection, little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice lacking the capacity to produce IgG ...