Now showing items 1-11 of 11

    • Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis 

      Berry, James Dale; Shefner, Jeremy M.; Conwit, Robin; Schoenfeld, David Alan; Keroack, Myles; Felsenstein, Donna; Krivickas, Lisa; David, William Samuel; Vriesendorp, Francine; Pestronk, Alan; Caress, James B.; Katz, Jonathan; Simpson, Ericka; Rosenfeld, Jeffrey; Pascuzzi, Robert; Glass, Jonathan; Rezania, Kourosh; Rothstein, Jeffrey D.; Greenblatt, David J.; Cudkowicz, Merit Ester (Public Library of Science, 2013)
      Objectives: Ceftriaxone increases expression of the astrocytic glutamate transporter, EAAT2, which might protect from glutamate-mediated excitotoxicity. A trial using a novel three stage nonstop design, incorporating Phases ...
    • Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis 

      Alshikho, Mohamad J.; Zürcher, Nicole R.; Loggia, Marco L.; Cernasov, Paul; Chonde, Daniel B.; Izquierdo Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Lippincott Williams & Wilkins, 2016)
      Objective: In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. Methods: Ten individuals with amyotrophic lateral sclerosis ...
    • A High-Density Genome-Wide Association Screen of Sporadic ALS in US Veterans 

      Kwee, Lydia Coulter; Liu, Yutao; Haynes, Carol; Gibson, Jason R.; Stone, Annjanette; Schichman, Steven A.; Kamel, Freya; Nelson, Lorene M.; Topol, Barbara; Van Den Eeden, Stephen K.; Tanner, Caroline M.; Grasso, Daniela L.; Lawson, Robert; Muralidhar, Sumitra; Oddone, Eugene Z.; Schmidt, Silke; Hauser, Michael A.; Cudkowicz, Merit Ester (Public Library of Science, 2012)
      Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) of ALS outcome and survival time in a sample of ...
    • How common are ALS plateaus and reversals? 

      Bedlack, Richard S.; Vaughan, Timothy; Wicks, Paul; Heywood, Jamie; Sinani, Ervin; Selsov, Roger; Macklin, Eric A.; Schoenfeld, David; Cudkowicz, Merit; Sherman, Alex (Lippincott Williams & Wilkins, 2015)
      Objective: To determine the frequency of amyotrophic lateral sclerosis (ALS) plateaus and reversals in the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database. Methods: We analyzed Amyotrophic Lateral Sclerosis ...
    • Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28 

      Zürcher, Nicole R.; Loggia, Marco L.; Lawson, Robert; Chonde, Daniel B.; Izquierdo-Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Elsevier, 2015)
      Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo ...
    • Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort 

      Weisskopf, Marc G.; Cudkowicz, Merit E.; Johnson, Norman (Lippincott Williams & Wilkins, 2015)
      Background: Military service has been suggested to be associated with an increased risk of amyotrophic lateral sclerosis (ALS), but only one prospective study—of a volunteer cohort—has examined this question. Methods: We ...
    • Profound Muscle Weakness and Pain after One Dose of Actonel 

      Badayan, Irina; Cudkowicz, Merit Ester (Hindawi Publishing Corporation, 2009)
      The World Health Organization (WHO) defines osteopenia as a bone density between 1 and 2.5 standard deviation (SD) below the bone density of a normal young adult Iqbal 2000. Osteoporosis is defined as 2.5 SD or more below ...
    • Race/ethnicity, socioeconomic status, and ALS mortality in the United States 

      Roberts, Andrea L.; Johnson, Norman J.; Chen, Jarvis T.; Cudkowicz, Merit E.; Weisskopf, Marc G. (Lippincott Williams & Wilkins, 2016)
      Objective: To determine whether race/ethnicity and socioeconomic status are associated with amyotrophic lateral sclerosis (ALS) mortality in the United States. Methods: The National Longitudinal Mortality Study (NLMS), a ...
    • Safety, Pharmacokinetic, and Functional Effects of the Nogo-A Monoclonal Antibody in Amyotrophic Lateral Sclerosis: A Randomized, First-In-Human Clinical Trial 

      Meininger, Vincent; Pradat, Pierre-François; Corse, Andrea; Al-Sarraj, Safa; Rix Brooks, Benjamin; Caress, James B.; Cudkowicz, Merit; Kolb, Stephen J.; Lange, Dale; Leigh, P. Nigel; Meyer, Thomas; Milleri, Stefano; Morrison, Karen E.; Orrell, Richard W.; Peters, Gary; Rothstein, Jeffrey D.; Shefner, Jeremy; Lavrov, Arseniy; Williams, Nicola; Overend, Phil; Price, Jeffrey; Bates, Stewart; Bullman, Jonathan; Krull, David; Berges, Alienor; Abila, Bams; Meno-Tetang, Guy; Wurthner, Jens (Public Library of Science, 2014)
      The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in skeletal muscle in amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and therapeutic target. We performed a double-blind, ...
    • Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis 

      Qureshi, Muddasir; Brown Jr, Robert H; Rogers, Jack Timothy; Cudkowicz, Merit Ester (Bentham Open, 2008)
      Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels ...
    • Transcranial magnetic stimulation of the brain: guidelines for pain treatment research 

      Klein, Max M.; Treister, Roi; Raij, Tommi; Pascual-Leone, Alvaro; Park, Lawrence; Nurmikko, Turo; Lenz, Fred; Lefaucheur, Jean-Pascal; Lang, Magdalena; Hallett, Mark; Fox, Michael; Cudkowicz, Merit; Costello, Ann; Carr, Daniel B.; Ayache, Samar S.; Oaklander, Anne Louise (Wolters Kluwer, 2015)
      Abstract Recognizing that electrically stimulating the motor cortex could relieve chronic pain sparked development of noninvasive technologies. In transcranial magnetic stimulation (TMS), electromagnetic coils held against ...