Now showing items 1-9 of 9

    • Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward 

      Schiavo, Alfonso; Renis, Maurizio; Polverino, Mario; Iannuzzi, Arcangelo; Polverino, Francesca (BioMed Central, 2016)
      Background: Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrolite ...
    • Adam8 Limits the Development of Allergic Airway Inflammation in Mice 

      Knolle, M. D.; Nakajima, T.; Hergrueter, A.; Gupta, K.; Polverino, Francesca; Craig, V; Fyfe, S. E.; Zahid, M.; Permaul, Perdita; Cernadas, Manuela; Montano, Giancarlo Vengco; Tesfaigzi, Y.; Sholl, Lynette Marie; Kobzik, Lester; Israel, Elliot; Owen, Caroline Ann (The American Association of Immunologists, 2013)
      To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in ...
    • Anatomy and neuro-pathophysiology of the cough reflex arc 

      Polverino, Mario; Fasolino, Marco; Andò, Filippo; Alfieri, Antonio; De Blasio, Francesco; Polverino, Francesca (BioMed Central, 2012)
      Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of respiratory ...
    • Effects of sex hormones on bronchial reactivity during the menstrual cycle 

      Matteis, Maria; Polverino, Francesca; Spaziano, Giuseppe; Roviezzo, Fiorentina; Santoriello, Carlo; Sullo, Nikol; Bucci, Maria Rosaria; Rossi, Francesco; Polverino, Mario; Owen, Caroline A; D’Agostino, Bruno (BioMed Central, 2014)
      Background: Many asthmatic women complain of symptom exacerbations in particular periods, i.e. during pregnancy and menstrual cycles (perimenstrual asthma: PMA)". The goal of this study was to study the effect of the luteal ...
    • Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring 

      Lao, Taotao; Glass, Kimberly; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Morrow, Jarrett; Mancini, John Dominic; Vuong, Linh; Perrella, Mark A; Hersh, Craig P; Owen, Caroline A; Quackenbush, John; Yuan, Guo-Cheng; Silverman, Edwin K; Zhou, Xiaobo (BioMed Central, 2015)
      Background: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a ...
    • Idiopathic pulmonary fibrosis and coronary artery disease 

      Cicchitto, Gaetano; Musella, Valentina; Acitorio, Maria; Capuano, Nicola; Fiorenzano, Giuseppe; Owen, Caroline A; Polverino, Mario; Polverino, Francesca (BioMed Central, 2014)
      Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial ...
    • Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer? 

      Polverino, Francesca; Laucho-Contreras, Maria; Rojas Quintero, Joselyn; Divo, Miguel; Pinto-Plata, Victor; Sholl, Lynette; de-Torres, Juan P.; Celli, Bartolome R.; Owen, Caroline A. (BioMed Central, 2016)
      Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by an excessive activation of the adaptive immune system and, in particular, uncontrolled expansion of the B-cell pool. One of the key promoters of ...
    • Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice 

      Cloonan, Suzanne M.; Glass, Kimberly; Laucho-Contreras, Maria E.; Bhashyam, Abhiram R.; Cervo, Morgan; Pabón, Maria A.; Konrad, Csaba; Polverino, Francesca; Siempos, Ilias I.; Perez, Elizabeth; Mizumura, Kenji; Ghosh, Manik C.; Parameswaran, Harikrishnan; Williams, Niamh C.; Rooney, Kristen T.; Chen, Zhi-Hua; Goldklang, Monica P.; Yuan, Guo-Cheng; Moore, Stephen C.; Demeo, Dawn L.; Rouault, Tracey A.; D’Armiento, Jeanine M.; Schon, Eric A.; Manfredi, Giovanni; Quackenbush, John; Mahmood, Ashfaq; Silverman, Edwin K.; Owen, Caroline A.; Choi, Augustine M.K. (2015)
      Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as an important COPD susceptibility ...
    • Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis 

      Craig, Vanessa J.; Polverino, Francesca; Laucho-Contreras, Maria E.; Shi, Yuanyuan; Liu, Yushi; Osorio, Juan C.; Tesfaigzi, Yohannes; Pinto-Plata, Victor; Gochuico, Bernadette R.; Rosas, Ivan O.; Owen, Caroline A. (Public Library of Science, 2014)
      Objectives: Matrix metalloproteinase-8 (MMP-8) promotes lung fibrotic responses to bleomycin in mice. Although prior studies reported that MMP-8 levels are increased in plasma and bronchoalveolar lavage fluid (BALF) samples ...