Now showing items 1-14 of 14

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...
    • Association of IREB2 and CHRNA3 Polymorphisms with Airflow Obstruction in Severe Alpha-1 Antitrypsin Deficiency 

      Wood, Alice M; Barker, Alan F; Brantly, Mark L; Campbell, Edward J; Eden, Edward; McElvaney, Gerard; Rennard, Stephen I; Sandhaus, Robert A; Stocks, James M; Stoller, James K; Strange, Charlie; Turino, Gerard; Stockley, Robert A; Silverman, Edwin Kepner; Demeo, Dawn Lisa; Kim, Woo Jin (BioMed Central, 2012)
      Background: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have ...
    • Bipartite Community Structure of eQTLs 

      Platig, John; Castaldi, Peter J.; DeMeo, Dawn; Quackenbush, John (Public Library of Science, 2016)
      Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL) analyses have identified genetic associations with a wide range of human phenotypes. However, many of these variants have weak effects ...
    • Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood 

      Agha, Golareh; Hajj, Hanine; Rifas-Shiman, Sheryl L.; Just, Allan C.; Hivert, Marie-France; Burris, Heather H.; Lin, Xihong; Litonjua, Augusto A.; Oken, Emily; DeMeo, Dawn L.; Gillman, Matthew W.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ...
    • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 

      Sun, Wei; Kechris, Katerina; Jacobson, Sean; Drummond, M. Bradley; Hawkins, Gregory A.; Yang, Jenny; Chen, Ting-huei; Quibrera, Pedro Miguel; Anderson, Wayne; Barr, R. Graham; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri; Casaburi, Richard; Castaldi, Peter; Cho, Michael H.; Comellas, Alejandro; Crapo, James D.; Criner, Gerard; Demeo, Dawn; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, MeiLan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O’Neal, Wanda K.; Bowler, Russell P. (Public Library of Science, 2016)
      Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental ...
    • A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data 

      Li, Xuan; Qiu, Weiliang; Morrow, Jarrett; DeMeo, Dawn L.; Weiss, Scott T.; Fu, Yuejiao; Wang, Xiaogang (Public Library of Science, 2015)
      Variable DNA methylation has been associated with cancers and complex diseases. Researchers have identified many DNA methylation markers that have different mean methylation levels between diseased subjects and normal ...
    • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 

      Lutz, Sharon M.; Cho, Michael H.; Young, Kendra; Hersh, Craig P.; Castaldi, Peter J.; McDonald, Merry-Lynn; Regan, Elizabeth; Mattheisen, Manuel; DeMeo, Dawn L.; Parker, Margaret; Foreman, Marilyn; Make, Barry J.; Jensen, Robert L.; Casaburi, Richard; Lomas, David A.; Bhatt, Surya P.; Bakke, Per; Gulsvik, Amund; Crapo, James D.; Beaty, Terri H.; Laird, Nan M.; Lange, Christoph; Hokanson, John E.; Silverman, Edwin K. (BioMed Central, 2015)
      Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...
    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...
    • Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice 

      Cloonan, Suzanne M.; Glass, Kimberly; Laucho-Contreras, Maria E.; Bhashyam, Abhiram R.; Cervo, Morgan; Pabón, Maria A.; Konrad, Csaba; Polverino, Francesca; Siempos, Ilias I.; Perez, Elizabeth; Mizumura, Kenji; Ghosh, Manik C.; Parameswaran, Harikrishnan; Williams, Niamh C.; Rooney, Kristen T.; Chen, Zhi-Hua; Goldklang, Monica P.; Yuan, Guo-Cheng; Moore, Stephen C.; Demeo, Dawn L.; Rouault, Tracey A.; D’Armiento, Jeanine M.; Schon, Eric A.; Manfredi, Giovanni; Quackenbush, John; Mahmood, Ashfaq; Silverman, Edwin K.; Owen, Caroline A.; Choi, Augustine M.K. (2015)
      Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as an important COPD susceptibility ...
    • Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report 

      Agusti, Alvar; Anderson, Wayne; Bakke, Per S; Barnes, Kathleen C; Barr, R Graham; Bleecker, Eugene R; Boezen, H Marike; Burkart, Kristin M; Cookson, William OC; Croxton, Thomas; Daley, Denise; Gan, Weiniu; Garcia-Aymerich, Judith; Hall, Ian P; Hansel, Nadia N; Kalsheker, Noor; Kiley, James P; Lambrechts, Diether; Lee, Sang-Do; Lomas, David A; London, Stephanie J; Nishimura, Masaharu; Postma, Dirkje S; Puhan, Milo A; Tesfaigzi, Yohannes; Tobin, Martin D; Vogelmeier, Claus; Wouters, Emiel; Ziegler-Heitbrock, Loems; MacNee, William; Crapo, James D; Vestbo, Jørgen; Silverman, Edwin Kepner; Cho, Michael Hyosang; Celli, Bartolome R; Demeo, Dawn Lisa; Hersh, Craig Palmer; Wilk, Jemma B; Nørdestgaard, Borge G.; Young, Robert P.; O'Donnell, Christopher J.; Kim, Woo Jin; Litonjua, Augusto Ampil (Informa Healthcare, 2011)
    • Sexually-dimorphic targeting of functionally-related genes in COPD 

      Glass, Kimberly; Quackenbush, John; Silverman, Edwin K; Celli, Bartolome; Rennard, Stephen I; Yuan, Guo-Cheng; DeMeo, Dawn L (BioMed Central, 2014)
      Background: There is growing evidence that many diseases develop, progress, and respond to therapy differently in men and women. This variability may manifest as a result of sex-specific structures in gene regulatory ...
    • A Simplified Score to Quantify Comorbidity in COPD 

      Putcha, Nirupama; Puhan, Milo A.; Drummond, M. Bradley; Han, MeiLan K.; Regan, Elizabeth A.; Hanania, Nicola A.; Martinez, Carlos H.; Foreman, Marilyn; Bhatt, Surya P.; Make, Barry; Ramsdell, Joe; DeMeo, Dawn L.; Barr, R. Graham; Rennard, Stephen I.; Martinez, Fernando; Silverman, Edwin K.; Crapo, James; Wise, Robert A.; Hansel, Nadia N. (Public Library of Science, 2014)
      Importance Comorbidities are common in COPD, but quantifying their burden is difficult. Currently there is a COPD-specific comorbidity index to predict mortality and another to predict general quality of life. We sought ...
    • Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function 

      Qiu, Weiliang; Baccarelli, Andrea; Carey, Vincent James; Boutaoui, Nadia; Bacherman, Helene; Klanderman, Barbara; Rennard, Stephen; Agusti, Alvar; Anderson, Wayne; Lomas, David A.; Demeo, Dawn Lisa (American Thoracic Society, 2012)
      Rationale: Chronic obstructive pulmonary disease (COPD) is associated with local (lung) and systemic (blood) inflammation and manifestations. DNA methylation is an important regulator of gene transcription, and global and ...
    • Xenobiotic Metabolizing Enzyme Gene Polymorphisms Predict Response to Lung Volume Reduction Surgery 

      Hersh, Craig Palmer; Demeo, Dawn Lisa; Reilly, John J.; Silverman, Edwin Kepner (BioMed Central, 2007)
      Background: In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this ...