Now showing items 1-2 of 2

    • Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling 

      Charbonnier, Louis-Marie; Wang, Sen; Georgiev, Peter; Sefik, Esen; Chatila, Talal A (2015)
      Notch receptors direct the differentiation of T helper (TH) cell subsets, but their influence on regulatory T (Treg) cell responses is obscure. We here report that lineage-specific deletion of components of the Notch pathway ...
    • Individual Microbes Shape Various Parts of the Immune System 

      Sefik, Esen (2015-09-22)
      The gastrointestinal tract, home to a vast number of bacteria, requires finely-tuned regulatory and effector immune mechanisms to maintain homeostasis and tolerance. In a large-scale screen, we studied the impacts of single ...