Now showing items 1-20 of 37

    • Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors 

      Eberlin, L. S.; Norton, I.; Orringer, D.; Dunn, Ian Frederick; Liu, X.; Ide, J. L.; Jarmusch, A. K.; Ligon, Keith Lloyd; Jolesz, Ferenc A.; Golby, Alexandra Jacqueline; Santagata, Sandro; Agar, Nathalie Marie Yvonne Rachel; Cooks, R. G. (Proceedings of the National Academy of Sciences, 2013)
      The main goal of brain tumor surgery is to maximize tumor resection while preserving brain function. However, existing imaging and surgical techniques do not offer the molecular information needed to delineate tumor ...
    • Automated white matter fiber tract identification in patients with brain tumors 

      O’Donnell, Lauren J.; Suter, Yannick; Rigolo, Laura; Kahali, Pegah; Zhang, Fan; Norton, Isaiah; Albi, Angela; Olubiyi, Olutayo; Meola, Antonio; Essayed, Walid I.; Unadkat, Prashin; Ciris, Pelin Aksit; Wells, William M.; Rathi, Yogesh; Westin, Carl-Fredrik; Golby, Alexandra J. (Elsevier, 2016)
      We propose a method for the automated identification of key white matter fiber tracts for neurosurgical planning, and we apply the method in a retrospective study of 18 consecutive neurosurgical patients with brain tumors. ...
    • Bayesian characterization of uncertainty in intra-subject non-rigid registration 

      Risholm, Petter; Janoos, Firdaus; Norton, Isaiah Hakim; Golby, Alexandra Jacqueline; Wells, William Mercer (Elsevier BV, 2013)
      In settings where high-level inferences are made based on registered image data, the registration uncertainty can contain important information. In this article, we propose a Bayesian non-rigid registration framework where ...
    • Chiasmal visual loss after retinal detachment 

      Prasad, Sashank; Golby, Alexandra Jacqueline (Ovid Technologies (Wolters Kluwer Health), 2012)
      A 52-year-old man developed severe vision loss in the right eye due to a large retinal detachment. Vitrectomy was performed in that eye, with 15% C3F8 perfluoropropane gas injected into the posterior chamber.1 He transiently ...
    • A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference 

      Propper, Ruth E.; O’Donnell, Lauren J.; Whalen, Stephen; Tie, Yanmei; Norton, Isaiah Hakim; Suarez, Ralph O.; Zollei, Lilla; Radmanesh, Alireza; Golby, Alexandra Jacqueline (Elsevier BV, 2010)
      The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca’s and Wernicke’s areas, and structural measures of the arcuate fasciculus. Results ...
    • Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy 

      Reinsberger, Claus; Tanaka, Naoaki; Cole, Andrew J.; Lee, Jong Woo; Dworetzky, Barbara Ann; Bromfield, Edward B.; Hamiwka, Lorie; Bourgeois, Blaise F.D.; Golby, Alexandra Jacqueline; Madsen, Joseph Russell; Stufflebeam, Steven Marshall (Elsevier BV, 2010)
      To evaluate cortical architecture in mesial temporal lobe epilepsy (MTLE) with respect to electrophysiology, we analyze both magnetic resonance imaging (MRI) and magnetoencephalography (MEG) in 19 patients with left MTLE. ...
    • Defining language networks from resting-state fMRI for surgical planning-a feasibility study 

      Tie, Yanmei; Rigolo, Laura; Norton, Isaiah Hakim; Huang, Raymond Y; Wu, Wentao; Orringer, Daniel; Mukundan, Srinivasan; Golby, Alexandra Jacqueline (Wiley-Blackwell, 2013)
      Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI ...
    • Development of a Clinical Functional Magnetic Resonance Imaging Service 

      Rigolo, Laura; Stern, Emily; Deaver, Pamela Marie; Golby, Alexandra Jacqueline; Mukundan, Srinivasan (Elsevier BV, 2011)
      One of the limitations of anatomical based imaging approaches is its relative inability to identify whether specific brain functions may be compromised by the location of brain lesions or contemplated brain surgeries. For ...
    • Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery 

      Agar, Nathalie Marie Yvonne Rachel; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Norton, Isaiah Hakim; Mohan, Vandana; Wiseman, Justin M; Tannenbaum, Allen; Jolesz, Ferenc A. (Oxford University Press (OUP), 2011)
      BACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. ...
    • Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry 

      Eberlin, Livia S.; Dill, Allison L.; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Wiseman, Justin M.; Cooks, R. Graham; Agar, Nathalie Marie Yvonne Rachel (Wiley-Blackwell, 2010)
    • Extended Broca’s Area in the Functional Connectome of Language in Adults: Combined Cortical and Subcortical Single-Subject Analysis Using fMRI and DTI Tractography 

      Lemaire, Jean-Jacques; Golby, Alexandra Jacqueline; Wells, William Mercer; Pujol, Sonia; Tie, Yanmei; Rigolo, Laura; Yarmarkovich, Alexander; Pieper, Steve; Westin, Carl-Fredrik; Jolesz, Ferenc A.; Kikinis, Ron (Springer Nature, 2012)
      Traditional models of the human language circuitry encompass three cortical areas, Broca’s, Geschwind’s and Wernicke’s, and their connectivity through white matter fascicles. The neural connectivity deep to these cortical ...
    • Fiber clustering versus the parcellation-based connectome 

      O'Donnell, Lauren Jean; Golby, Alexandra Jacqueline; Westin, Carl-Fredrik (Elsevier BV, 2013)
      We compare two strategies for modeling the connections of the brain's white matter: fiber clustering and the parcellation-based connectome. Both methods analyze diffusion magnetic resonance imaging fiber tractography to ...
    • The Fiber Laterality Histogram: A New Way to Measure White Matter Asymmetry 

      O’Donnell, Lauren J.; Westin, Carl-Fredrik; Norton, Isaiah Hakim; Whalen, Stephen; Rigolo, Laura; Propper, Ruth; Golby, Alexandra Jacqueline (Springer Berlin Heidelberg, 2010)
      The quantification of brain asymmetries may provide biomarkers for presurgical localization of language function and can improve our understanding of neural structure-function relationships in health and disease. We propose ...
    • fMRI-DTI modeling via landmark distance atlases for prediction and detection of fiber tracts 

      O'Donnell, Lauren Jean; Rigolo, Laura; Norton, Isaiah; Wells, William Mercer; Westin, Carl-Fredrik; Golby, Alexandra Jacqueline (Elsevier BV, 2012)
      The overall goal of this research is the design of statistical atlas models that can be created from normal subjects, but may generalize to be applicable to abnormal brains. We present a new style of joint modeling of fMRI, ...
    • Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia 

      Monje, Michelle; Thomason, Moriah E.; Rigolo, Laura; Wang, Yalin; Waber, Deborah Paula; Sallan, Stephen Earl; Golby, Alexandra Jacqueline (Wiley-Blackwell, 2013)
      Background Radiation and chemotherapy targeted to the central nervous system (CNS) can cause cognitive impairment, including impaired memory. These memory impairments may be referable to damage to hippocampal structures ...
    • GBM Volumetry using the 3D Slicer Medical Image Computing Platform 

      Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra Jacqueline; Nimsky, Christopher; Kikinis, Ron (Nature Publishing Group, 2013)
      Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. ...
    • Interactive Diffusion Tensor Tractography Visualization for Neurosurgical Planning 

      Golby, Alexandra Jacqueline; Kindlmann, Gordon; Norton, Isaiah Hakim; Yarmarkovich, Alexander; Pieper, Steven; Kikinis, Ron (Oxford University Press (OUP), 2011)
      BACKGROUND: Diffusion tensor imaging (DTI) infers the trajectory and location of large white matter tracts by measuring the anisotropic diffusion of water. DTI data may then be analyzed and presented as tractography for ...
    • Intraoperative Real-Time Querying of White Matter Tracts During Frameless Stereotactic Neuronavigation 

      Elhawary, Haytham; Liu, Haiying; Patel, Pratik; Norton, Isaiah Hakim; Rigolo, Laura; Papademetris, Xenophon; Hata, Nobuhiko; Golby, Alexandra Jacqueline (Oxford University Press (OUP), 2011)
      BACKGROUND: Brain surgery faces important challenges when trying to achieve maximum tumor resection while avoiding postoperative neurological deficits. OBJECTIVE: For surgeons to have optimal intraoperative information ...
    • Learning an Atlas of a Cognitive Process in Its Functional Geometry 

      Langs, Georg; Lashkari, Danial; Sweet, Andrew; Tie, Yanmei; Rigolo, Laura; Golby, Alexandra Jacqueline; Golland, Polina (Springer Science + Business Media, 2011)
      In this paper we construct an atlas that captures functional characteristics of a cognitive process from a population of individuals. The functional connectivity is encoded in a low-dimensional embedding space derived from ...
    • Morphological Characteristics of Brain Tumors Causing Seizures 

      Lee, Jong Woo; Wen, Patrick Yung Chih; Hurwitz, Shelley; Black, Peter McLaren; Kesari, Santosh; Drappatz, Jan; Golby, Alexandra Jacqueline; Wells, William Mercer; Warfield, Simon Keith; Kikinis, Ron; Bromfield, Edward B. (American Medical Association (AMA), 2010)
      Objective: To quantify size and localization differences between tumors presenting with seizures vs nonseizure neurological symptoms. Design: Retrospective imaging survey. We performed magnetic resonance imaging–based ...