Now showing items 1-5 of 5

    • Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia 

      Laidlaw, Kamilla M.E.; Berhan, Samuel; Liu, Suhu; Silvestri, Giovannino; Holyoake, Tessa L.; Frank, David A.; Aggarwal, Bharat; Bonner, Michael Y.; Perrotti, Danilo; Jørgensen, Heather G.; Arbiser, Jack L. (Impact Journals LLC, 2016)
      The use of tyrosine kinase inhibitors (TKI), including nilotinib, has revolutionized the treatment of chronic myeloid leukemia (CML). However current unmet clinical needs include combating activation of additional survival ...
    • Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia 

      Toniolo, Patricia A.; Liu, Suhu; Yeh, Jennifer E.; Ye, Darwin Q.; Barbuto, José Alexandre M.; Frank, David A. (Impact Journals LLC, 2016)
      One cause of morbidity and mortality in chronic lymphocytic leukemia (CLL) is infection, which results from defects in a number of components of the immune system. In particular, dendritic cells (DCs) are functionally ...
    • STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF- B to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes 

      Xiang, Michael; Birkbak, Nicolai Juul; Vafaizadeh, V.; Walker, Sarah Rebecca; Yeh, Jennifer E; Liu, Suhu; Kroll, Yasmin; Boldin, M.; Taganov, K.; Groner, B.; Richardson, Andrea Lynn; Frank, David Alan (American Association for the Advancement of Science (AAAS), 2014)
      Interleukin-6 (IL-6)–mediated activation of signal transducer and activator of transcription 3 (STAT3) is a mechanism by which chronic inflammation can contribute to cancer and is a common oncogenic event. We discovered a ...
    • Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2 

      Liu, Suhu; Walker, Sarah Rebecca; Nelson, E; Cerulli, R.; Xiang, Michael; Toniolo, P. A.; Qi, Jun; Stone, Richard Maury; Wadleigh, Martha; Bradner, James Elliott; Frank, David Alan (American Association for Cancer Research (AACR), 2014)
      The transcription factor signal STAT5 is constitutively activated in a wide range of leukemias and lymphomas, and drives the expression of genes necessary for proliferation, survival, and self-renewal. Thus, targeting STAT5 ...
    • The transcriptional modulator BCL6 as a molecular target for breast cancer therapy 

      Walker, Sarah R.; Liu, Suhu; Xiang, Michael; Nicolais, Maria; Hatzi, Katerina; Giannopoulou, Eugenia; Elemento, Olivier; Cerchietti, Leandro; Melnick, Ari; Frank, David A. (2014)
      Inappropriate expression or activation of transcription factors can drive patterns of gene expression leading to the malignant behavior of breast cancer cells. We have found that the transcriptional repressor BCL6 is highly ...