Now showing items 1-11 of 11

    • An Active Learning Approach for Rapid Characterization of Endothelial Cells in Human Tumors 

      Padmanabhan, Raghav K.; Somasundar, Vinay H.; Griffith, Sandra D.; Zhu, Jianliang; Samoyedny, Drew; Tan, Kay See; Hu, Jiahao; Liao, Xuejun; Carin, Lawrence; Yoon, Sam S.; Flaherty, Keith T.; DiPaola, Robert S.; Heitjan, Daniel F.; Lal, Priti; Feldman, Michael D.; Roysam, Badrinath; Lee, William M. F. (Public Library of Science, 2014)
      Currently, no available pathological or molecular measures of tumor angiogenesis predict response to antiangiogenic therapies used in clinical practice. Recognizing that tumor endothelial cells (EC) and EC activation and ...
    • BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes 

      Cooper, Zachary A; Frederick, Dennie T; Juneja, Vikram R; Sullivan, Ryan J; Lawrence, Donald P; Piris, Adriano; Sharpe, Arlene H; Fisher, David E; Flaherty, Keith T; Wargo, Jennifer A (Landes Bioscience, 2013)
      There have been significant advances with regard to BRAF-targeted therapies against metastatic melanoma. However, the majority of patients receiving BRAF inhibitors (BRAFi) manifest disease progression within a year. We ...
    • Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics 

      Frederick, Dennie T.; Salas Fragomeni, Roberto A.; Schalck, Aislyn; Ferreiro-Neira, Isabel; Hoff, Taylor; Cooper, Zachary A.; Haq, Rizwan; Panka, David J.; Kwong, Lawrence N.; Davies, Michael A.; Cusack, James C.; Flaherty, Keith T.; Fisher, David E.; Mier, James W.; Wargo, Jennifer A.; Sullivan, Ryan J. (Public Library of Science, 2014)
      While response rates to BRAF inhibitiors (BRAFi) are high, disease progression emerges quickly. One strategy to delay the onset of resistance is to target anti-apoptotic proteins such as BCL-2, known to be associated with ...
    • Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma 

      Cooper, Zachary A.; Reuben, Alexandre; Spencer, Christine N.; Prieto, Peter A.; Austin-Breneman, Jacob L.; Jiang, Hong; Haymaker, Cara; Gopalakrishnan, Vancheswaran; Tetzlaff, Michael T.; Frederick, Dennie T.; Sullivan, Ryan J.; Amaria, Rodabe N.; Patel, Sapna P.; Hwu, Patrick; Woodman, Scott E.; Glitza, Isabella C.; Diab, Adi; Vence, Luis M.; Rodriguez-Canales, Jaime; Parra, Edwin R.; Wistuba, Ignacio I.; Coussens, Lisa M.; Sharpe, Arlene H.; Flaherty, Keith T.; Gershenwald, Jeffrey E.; Chin, Lynda; Davies, Michael A.; Clise-Dwyer, Karen; Allison, James P.; Sharma, Padmanee; Wargo, Jennifer A. (Taylor & Francis, 2016)
      ABSTRACT We have made major advances in the treatment of melanoma through the use of targeted therapy and immune checkpoint blockade; however, clinicians are posed with therapeutic dilemmas regarding timing and sequence ...
    • Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation 

      Kim, Hyungsoo; Frederick, Dennie T.; Levesque, Mitchell P.; Cooper, Zachary A.; Feng, Yongmei; Krepler, Clemens; Brill, Laurence; Samuels, Yardena; Hayward, Nicholas K.; Perlina, Ally; Piris, Adriano; Zhang, Tongwu; Halaban, Ruth; Herlyn, Meenhard M.; Brown, Kevin M.; Wargo, Jennifer A.; Dummer, Reinhard; Flaherty, Keith T.; Ronai, Ze’ev A. (2015)
      SUMMARY Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF inhibitors (BRAFi), most tumors become resistant. Here, we identified the downregulation of the ubiquitin ligase RNF125 in ...
    • Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment 

      Friedman, Adam A.; Amzallag, Arnaud; Pruteanu-Malinici, Iulian; Baniya, Subash; Cooper, Zachary A.; Piris, Adriano; Hargreaves, Leeza; Igras, Vivien; Frederick, Dennie T.; Lawrence, Donald P.; Haber, Daniel A.; Flaherty, Keith T.; Wargo, Jennifer A.; Ramaswamy, Sridhar; Benes, Cyril H.; Fisher, David E. (Public Library of Science, 2015)
      A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses ...
    • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition 

      Johannessen, Cory M.; Johnson, Laura A.; Piccioni, Federica; Townes, Aisha; Frederick, Dennie T.; Donahue, Melanie K.; Narayan, Rajiv; Flaherty, Keith T.; Wargo, Jennifer A.; Root, David E.; Garraway, Levi A. (2014)
      BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents ...
    • Melanoma and immunotherapy bridge 2015: Naples, Italy. 1–5 December 2015 

      Nanda, Vashisht G. Y.; Peng, Weiyi; Hwu, Patrick; Davies, Michael A.; Ciliberto, Gennaro; Fattore, Luigi; Malpicci, Debora; Aurisicchio, Luigi; Ascierto, Paolo Antonio; Croce, Carlo M.; Mancini, Rita; Spranger, Stefani; Gajewski, Thomas F.; Wang, Yangyang; Ferrone, Soldano; Vanpouille-Box, Claire; Wennerberg, Erik; Pilones, Karsten A.; Formenti, Silvia C.; Demaria, Sandra; Tang, Haidong; Wang, Yang; Fu, Yang-Xin; Dummer, Reinhard; Puzanov, Igor; Tarhini, Ahmad; Chauvin, Joe-Marc; Pagliano, Ornella; Fourcade, Julien; Sun, Zhaojun; Wang, Hong; Sanders, Cindy; Kirkwood, John M.; Chen, Tseng-hui Timothy; Maurer, Mark; Korman, Alan J.; Zarour, Hassane M.; Stroncek, David F.; Huber, Veronica; Rivoltini, Licia; Thurin, Magdalena; Rau, Tilman; Lugli, Alessandro; Pagès, Franck; Camarero, Jorge; Sancho, Arantxa; Jommi, Claudio; de Coaña, Yago Pico; Wolodarski, Maria; Yoshimoto, Yuya; Gentilcore, Giusy; Poschke, Isabel; Masucci, Giuseppe V.; Hansson, Johan; Kiessling, Rolf; Scognamiglio, Giosuè; Sabbatino, Francesco; Marino, Federica Zito; Anniciello, Anna Maria; Cantile, Monica; Cerrone, Margherita; Scala, Stefania; D’alterio, Crescenzo; Ianaro, Angela; Cirin, Giuseppe; Liguori, Giuseppina; Bott, Gerardo; Chapman, Paul B.; Robert, Caroline; Larkin, James; Haanen, John B.; Ribas, Antoni; Hogg, David; Hamid, Omid; Testori, Alessandro; Lorigan, Paul; Sosman, Jeffrey A.; Flaherty, Keith T.; Yue, Huibin; Coleman, Shelley; Caro, Ivor; Hauschild, Axel; McArthur, Grant A.; Sznol, Mario; Callahan, Margaret K.; Kluger, Harriet; Postow, Michael A.; Gordan, RuthAnn; Segal, Neil H.; Rizvi, Naiyer A.; Lesokhin, Alexander; Atkins, Michael B.; Burke, Matthew M.; Ralabate, Amanda; Rivera, Angel; Kronenberg, Stephanie A.; Agunwamba, Blessing; Ruisi, Mary; Horak, Christine; Jiang, Joel; Wolchok, Jedd; Ascierto, Paolo A.; Liszkay, Gabriella; Maio, Michele; Mandalà, Mario; Demidov, Lev; Stoyakovskiy, Daniil; Thomas, Luc; de la Cruz-Merino, Luis; Atkinson, Victoria; Dutriaux, Caroline; Garbe, Claus; Wongchenko, Matthew; Chang, Ilsung; Koralek, Daniel O.; Rooney, Isabelle; Yan, Yibing; Dréno, Brigitte; Sullivan, Ryan; Patel, Manish; Hodi, Stephen; Amaria, Rodabe; Boasberg, Peter; Wallin, Jeffrey; He, Xian; Cha, Edward; Richie, Nicole; Ballinger, Marcus; Smith, David C.; Bauer, Todd M.; Wasser, Jeffrey S.; Luke, Jason J.; Balmanoukian, Ani S.; Kaufman, David R.; Zhao, Yufan; Maleski, Janet; Leopold, Lance; Gangadhar, Tara C.; Long, Georgina V.; Michielin, Olivier; VanderWalde, Ari; Andtbacka, Robert H. I.; Cebon, Jonathan; Fernandez, Eugenio; Malvehy, Josep; Olszanski, Anthony J.; Gause, Christine; Chen, Lisa; Chou, Jeffrey; Stephen Hodi, F.; Brady, Benjamin; Mortier, Laurent; Hassel, Jessica C.; Rutkowski, Piotr; McNeil, Catriona; Kalinka-Warzocha, Ewa; Lebbé, Celeste; Ny, Lars; Chacon, Matias; Queirolo, Paola; Loquai, Carmen; Cheema, Parneet; Berrocal, Alfonso; Eizmendi, Karmele Mujika; Bar-Sela, Gil; Hardy, Helene; Weber, Jeffrey S.; Grob, Jean-Jacques; Marquez-Rodas, Ivan; Schmidt, Henrik; Briscoe, Karen; Baurain, Jean-François; Wolchok, Jedd D.; Pinto, Rosamaria; De Summa, Simona; Garrisi, Vito Michele; Strippoli, Sabino; Azzariti, Amalia; Guida, Gabriella; Guida, Michele; Tommasi, Stefania; Jacquelot, Nicolas; Enot, David; Flament, Caroline; Pitt, Jonathan M.; Vimond, Nadège; Blattner, Carolin; Yamazaki, Takahiro; Roberti, Maria-Paula; Vetizou, Marie; Daillere, Romain; Poirier-Colame, Vichnou; la Semeraro, Michaë; Caignard, Anne; Slingluff, Craig L; Sallusto, Federica; Rusakiewicz, Sylvie; Weide, Benjamin; Marabelle, Aurélien; Kohrt, Holbrook; Dalle, Stéphane; Cavalcanti, Andréa; Kroemer, Guido; Di Giacomo, Anna Maria; Maio, Michaele; Wong, Phillip; Yuan, Jianda; Umansky, Viktor; Eggermont, Alexander; Zitvogel, Laurence; Anna, Passarelli; Marco, Tucci; Stefania, Stucci; Francesco, Mannavola; Mariaelena, Capone; Gabriele, Madonna; Antonio, Ascierto Paolo; Franco, Silvestris; Roberti, María Paula; Enot, David P.; Semeraro, Michaela; Jégou, Sarah; Flores, Camila; Kwon, Byoung S.; Anderson, Ana Carrizossa; Borg, Christophe; Aubin, François; Ayyoub, Maha; De Presbiteris, Anna Lisa; Cordaro, Fabiola Gilda; Camerlingo, Rosa; Fratangelo, Federica; Mozzillo, Nicola; Pirozzi, Giuseppe; Patriarca, Eduardo J.; Caputo, Emilia; Motti, Maria Letizia; Falcon, Rosaria; Miceli, Roberta; Capone, Mariaelena; Madonna, Gabriele; Mallardo, Domenico; Carrier, Maria Vincenza; Panza, Elisabetta; De Cicco, Paola; Armogida, Chiara; Ercolano, Giuseppe; Botti, Gerardo; Cirino, Giuseppe; Sandru, Angela; Blank, Miri; Balatoni, Timea; Olasz, Judit; Farkas, Emil; Szollar, Andras; Savolt, Akos; Godeny, Maria; Csuka, Orsolya; Horvath, Szabolcs; Eles, Klara; Shoenfeld, Yehuda; Kasler, Miklos; Costantini, Susan; Capone, Francesca; Moradi, Farnaz; Berglund, Pontus; Leandersson, Karin; Linnskog, Rickard; Andersson, Tommy; Prasad, Chandra Prakash; Nigro, Cristiana Lo; Lattanzio, Laura; Wang, Hexiao; Proby, Charlotte; Syed, Nelofer; Occelli, Marcella; Cauchi, Carolina; Merlano, Marco; Harwood, Catherine; Thompson, Alastair; Crook, Tim; Bifulco, Katia; Ingangi, Vincenzo; Minopoli, Michele; Ragone, Concetta; Pessi, Antonello; Mannavola, Francesco; D’Oronzo, Stella; Felici, Claudia; Tucci, Marco; Doronzo, Antonio; Silvestris, Franco; Ferretta, Anna; Guida, Stefania; Maida, Imma; Cocco, Tiziana; Passarelli, Anna; Quaresmini, Davide; Franzese, Ornella; Palermo, Belinda; Di Donna, Cosmo; Sperduti, Isabella; Foddai, MariaLaura; Stabile, Helena; Gismondi, Angela; Santoni, Angela; Nisticò, Paola; Sponghini, Andrea P.; Platini, Francesca; Marra, Elena; Rondonotti, David; Alabiso, Oscar; Fierro, Maria T.; Savoia, Paola; Stratica, Florian; Quaglino, Pietro; Di Monta, Gianluca; Corrado, Caracò; Di Marzo, Massimiliano; Ugo, Marone; Di Cecilia, Maria Luisa; Nicola, Mozzillo; Fusciello, Celeste; Marra, Antonio; Guarrasi, Rosario; Baldi, Carlo; Russo, Rosa; Di Giulio, Giovanni; Faiola, Vincenzo; Zeppa, Pio; Pepe, Stefano; Gambale, Elisabetta; Carella, Consiglia; Di Paolo, Alessandra; De Tursi, Michele; Marra, Laura; De Murtas, Fara; Sorrentino, Valeria; Voinea, Silviu; Panaitescu, Eugenia; Bolovan, Madalina; Stanciu, Adina; Cinca, Sabin; Botti, Chiara; Aquino, Gabriella; Anniciello, Annamaria; Fortes, Cristina; Mastroeni, Simona; Caggiati, Alessio; Passarelli, Francesca; Zappalà, Alba; Capuano, Maria; Bono, Riccardo; Nudo, Maurizio; Marino, Claudia; Michelozzi, Paola; De Biasio, Valeria; Battarra, Vincenzo C.; Formenti, Silvia; Ascierto, Maria Libera; McMiller, Tracee L.; Berger, Alan E.; Danilova, Ludmila; Anders, Robert A.; Netto, George J.; Xu, Haiying; Pritchard, Theresa S.; Fan, Jinshui; Cheadle, Chris; Cope, Leslie; Drake, Charles G.; Pardoll, Drew M.; Taube, Janis M.; Topalian, Suzanne L.; Gnjatic, Sacha; Nataraj, Sarah; Imai, Naoko; Rahman, Adeeb; Jungbluth, Achim A.; Pan, Linda; Venhaus, Ralph; Park, Andrew; Lehmann, Frédéric F.; Lendvai, Nikoletta; Cohen, Adam D.; Cho, Hearn J.; Daniel, Speiser; Hirsh, Vera (BioMed Central, 2016)
      Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick ...
    • Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma 

      Fofaria, Neel M.; Frederick, Dennie T.; Sullivan, Ryan J.; Flaherty, Keith T.; Srivastava, Sanjay K. (Impact Journals LLC, 2015)
      Melanoma harboring BRAF mutations frequently develop resistance to BRAF inhibitors, limiting the impact of treatment. Here, we establish a mechanism of resistance and subsequently identified a suitable drug combination to ...
    • PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation 

      Sabbatino, Francesco; Wang, Yangyang; Wang, Xinhui; Flaherty, Keith T.; Yu, Ling; Pepin, David; Scognamiglio, Giosue'; Pepe, Stefano; Kirkwood, John M.; Cooper, Zachary A.; Frederick, Dennie T.; Wargo, Jennifer A.; Ferrone, Soldano; Ferrone, Cristina R. (Impact Journals LLC, 2014)
      Control of BRAF(V600E) metastatic melanoma by BRAF inhibitor (BRAF-I) is limited by intrinsic and acquired resistance. Growth factor receptor up-regulation is among the mechanisms underlying BRAF-I resistance of melanoma ...
    • Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion 

      Straussman, Ravid; Morikawa, Teppei; Shee, Kevin; Barzily-Rokni, Michal; Qian, Zhi Rong; Du, Jinyan; Davis, Ashli; Mongare, Margaret M.; Gould, Joshua; Frederick, Dennie T.; Cooper, Zachary A.; Chapman, Paul B.; Solit, David B.; Ribas, Antoni; Lo, Roger S.; Flaherty, Keith T.; Ogino, Shuji; Wargo, Jennifer A.; Golub, Todd R. (2012)
      Drug resistance remains a vexing problem in the treatment of cancer patients. While many studies have focused on cell autonomous mechanisms of drug resistance, we hypothesized that the tumor microenvironment may confer ...