Now showing items 1-8 of 8

    • Cloud Computing for Comparative Genomics 

      Wall, Dennis Paul; Kudtarkar, Parul; Fusaro, Vincent Alfred; Pivovarov, Rimma; Patil, Prasad; Tonellato, Peter J (BioMed Central, 2010)
      Background: Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise. The capacity and cost of local computing infrastructures ...
    • Development of a Scalable Pharmacogenomic Clinical Decision Support Service 

      Fusaro, Vincent A.; Brownstein, Catherine; Wolf, Wendy; Clinton, Catherine; Savage, Sarah; Mandl, Kenneth D.; Margulies, David; Manzi, Shannon (American Medical Informatics Association, 2013)
      Advances in sequencing technology are making genomic data more accessible within the healthcare environment. Published pharmacogenetic guidelines attempt to provide a clinical context for specific genomic variants; however, ...
    • Early Detection of Poor Adherers to Statins: Applying Individualized Surveillance to Pay for Performance 

      Zimolzak, Andrew J.; Spettell, Claire M.; Fernandes, Joaquim; Fusaro, Vincent A.; Palmer, Nathan P.; Saria, Suchi; Kohane, Isaac S.; Jonikas, Magdalena A.; Mandl, Kenneth D. (Public Library of Science, 2013)
      Background: Medication nonadherence costs $300 billion annually in the US. Medicare Advantage plans have a financial incentive to increase medication adherence among members because the Centers for Medicare and Medicaid ...
    • Genotator: A Disease-Agnostic Tool for Genetic Annotation of Disease 

      Wall, Dennis Paul Paul; Pivovarov, Rimma; Tong, Mark; Jung, Jae-Yoon; Fusaro, Vincent Alfred; DeLuca, Todd; Tonellato, Peter J (BioMed Central, 2010)
      Background: Disease-specific genetic information has been increasing at rapid rates as a consequence of recent improvements and massive cost reductions in sequencing technologies. Numerous systems designed to capture and ...
    • Integration of a standardized pharmacogenomic platform for clinical decision support at Boston Children's Hospital 

      Brownstein, Catherine A.; Fusaro, Vincent Alfred; Savage, Sarah; Clinton, Catherine; Mandl, Kenneth David; Margulies, David Michael; Wolf, Wendy; Manzi, Shannon (BioMed Central, 2012)
    • The Potential of Accelerating Early Detection of Autism through Content Analysis of YouTube Videos 

      Fusaro, Vincent A.; Daniels, Jena; Duda, Marlena; DeLuca, Todd F.; D’Angelo, Olivia; Tamburello, Jenna; Maniscalco, James; Wall, Dennis P. (Public Library of Science, 2014)
      Abstract Autism is on the rise, with 1 in 88 children receiving a diagnosis in the United States, yet the process for diagnosis remains cumbersome and time consuming. Research has shown that home videos of children can ...
    • A Simulation Platform to Examine Heterogeneity Influence on Treatment 

      Chi, Chih-Lin; Fusaro, Vincent Alfred; Patil, Prasad; Crawford, Matthew A.; Content, Charles F.; Tonellato, Peter J. (American Medical Informatics Association, 2012)
      Although a protocol aims to guide treatment management and optimize overall outcomes, the benefits and harms for each individual vary due to heterogeneity. Some protocols integrate clinical and genetic variation to provide ...
    • Use of Machine Learning to Shorten Observation-based Screening and Diagnosis of Autism 

      Wall, Dennis Paul; Kosmicki, Jack Alphonse; DeLuca, Todd; Harstad, Elizabeth Borges; Fusaro, Vincent Alfred (Nature Publishing Group, 2012)
      The Autism Diagnostic Observation Schedule-Generic (ADOS) is one of the most widely used instruments for behavioral evaluation of autism spectrum disorders. It is composed of four modules, each tailored for a specific group ...