Now showing items 1-20 of 30

    • Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling 

      Beynon, Vanessa; Quintana, Francisco Javier; Weiner, Howard Lee (Public Library of Science, 2012)
      Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in ...
    • Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish 

      Quintana, Francisco Javier; Iglesias, Antonio H.; Farez, Mauricio F.; Caccamo, Mario; Burns, Evan J.; Kassam, Nasim; Oukka, Mohamed; Weiner, Howard Lee (Public Library of Science, 2010)
      Background: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens ...
    • Alterations of the human gut microbiome in multiple sclerosis 

      Jangi, Sushrut; Gandhi, Roopali; Cox, Laura M.; Li, Ning; von Glehn, Felipe; Yan, Raymond; Patel, Bonny; Mazzola, Maria Antonietta; Liu, Shirong; Glanz, Bonnie L.; Cook, Sandra; Tankou, Stephanie; Stuart, Fiona; Melo, Kirsy; Nejad, Parham; Smith, Kathleen; Topçuolu, Begüm D.; Holden, James; Kivisäkk, Pia; Chitnis, Tanuja; De Jager, Philip L.; Quintana, Francisco J.; Gerber, Georg K.; Bry, Lynn; Weiner, Howard L. (Nature Publishing Group, 2016)
      The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ...
    • Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis 

      Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)
      Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ...
    • Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis 

      Tauhid, Shahamat; Chu, Renxin; Sasane, Rahul; Glanz, Bonnie I.; Neema, Mohit; Miller, Jennifer R.; Kim, Gloria; Signorovitch, James E.; Healy, Brian C.; Chitnis, Tanuja; Weiner, Howard L.; Bakshi, Rohit (Springer Berlin Heidelberg, 2015)
      Multiple sclerosis (MS) commonly affects occupational function. We investigated the link between brain MRI and employment status. Patients with MS (n = 100) completed a Work Productivity and Activity Impairment (WPAI) ...
    • Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis 

      Regev, Keren; Paul, Anu; Healy, Brian; von Glenn, Felipe; Diaz-Cruz, Camilo; Gholipour, Taha; Mazzola, Maria Antonietta; Raheja, Radhika; Nejad, Parham; Glanz, Bonnie I.; Kivisakk, Pia; Chitnis, Tanuja; Weiner, Howard L.; Gandhi, Roopali (Lippincott Williams & Wilkins, 2016)
      Objective: To identify circulating microRNAs (miRNAs) linked to disease stage and disability in multiple sclerosis (MS). Methods: Sera from 296 participants including patients with MS, other neurologic diseases (Alzheimer ...
    • Differential roles of microglia and monocytes in the inflamed central nervous system 

      Yamasaki, Ryo; Lu, Haiyan; Butovsky, Oleg; Ohno, Nobuhiko; Rietsch, Anna M.; Cialic, Ron; Wu, Pauline M.; Doykan, Camille E.; Lin, Jessica; Cotleur, Anne C.; Kidd, Grahame; Zorlu, Musab M.; Sun, Nathan; Hu, Weiwei; Liu, LiPing; Lee, Jar-Chi; Taylor, Sarah E.; Uehlein, Lindsey; Dixon, Debra; Gu, Jinyu; Floruta, Crina M.; Zhu, Min; Charo, Israel F.; Weiner, Howard L.; Ransohoff, Richard M. (The Rockefeller University Press, 2014)
      In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ...
    • Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis 

      Kivisäkk, Pia; Francois, Katiana; Mbianda, Julvet; Gandhi, Roopali; Weiner, Howard L.; Khoury, Samia J. (Public Library of Science, 2014)
      Objectives: Dendritic cells (DCs) serve a critical role both in promoting and inhibiting adaptive immunity. The goal of this study was to investigate the effect of natalizumab (NTZ) treatment on DC numbers, phenotype, and ...
    • Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis 

      Bove, Riley; White, Charles C.; Giovannoni, Gavin; Glanz, Bonnie; Golubchikov, Victor; Hujol, Johnny; Jennings, Charles; Langdon, Dawn; Lee, Michelle; Legedza, Anna; Paskavitz, James; Prasad, Sashank; Richert, John; Robbins, Allison; Roberts, Susan; Weiner, Howard; Ramachandran, Ravi; Botfield, Martyn; De Jager, Philip L. (Lippincott Williams & Wilkins, 2015)
      Objective: In this cohort of individuals with and without multiple sclerosis (MS), we illustrate some of the novel approaches that smartphones provide to monitor patients with chronic neurologic disorders in their natural ...
    • Evaluation of an Online Platform for Multiple Sclerosis Research: Patient Description, Validation of Severity Scale, and Exploration of BMI Effects on Disease Course 

      Musallam, Alexander; Vaughan, Timothy; Wicks, Paul; Bove, Riley Marie; Secor, Elizabeth; Healy, Brian Curran; Glanz, Bonnie; Greeke, Emily Elizabeth; Weiner, Howard Lee; Chitnis, Tanuja; De Jager, Philip Lawrence (Public Library of Science, 2013)
      Objectives: To assess the potential of an online platform, PatientsLikeMe.com (PLM), for research in multiple sclerosis (MS). An investigation of the role of body mass index (BMI) on MS disease course was conducted to ...
    • An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2 

      Bakshi, Rohit; Neema, Mohit; Tauhid, Shahamat; Healy, Brian C.; Glanz, Bonnie I.; Kim, Gloria; Miller, Jennifer; Berkowitz, Julia L.; Bove, Riley; Houtchens, Maria K.; Severson, Christopher; Stankiewicz, James M.; Stazzone, Lynn; Chitnis, Tanuja; Guttmann, Charles R.G.; Weiner, Howard L.; Ceccarelli, Antonia (Lippincott Williams & Wilkins, 2014)
      The objective of this study was to test a new version of the Magnetic Resonance Disease Severity Scale (MRDSS2), incorporating cerebral gray matter (GM) and spinal cord involvement from 3 T MRI, in modeling the relationship ...
    • Extracellular RNAs: development as biomarkers of human disease 

      Quinn, Joseph F.; Patel, Tushar; Wong, David; Das, Saumya; Freedman, Jane E.; Laurent, Louise C.; Carter, Bob S.; Hochberg, Fred; Keuren-Jensen, Kendall Van; Huentelman, Matt; Spetzler, Robert; Kalani, M. Yashar S.; Arango, Jorge; Adelson, P. David; Weiner, Howard L.; Gandhi, Roopali; Goilav, Beatrice; Putterman, Chaim; Saugstad, Julie A. (Co-Action Publishing, 2015)
      Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, ...
    • Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models 

      Chua, Alicia S.; Egorova, Svetlana; Anderson, Mark C.; Polgar-Turcsanyi, Mariann; Chitnis, Tanuja; Weiner, Howard L.; Guttmann, Charles R.G.; Bakshi, Rohit; Healy, Brian C. (Elsevier, 2015)
      Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the ...
    • Identification and characterization of latency-associated peptide-expressing γδ T cells 

      Rezende, Rafael M.; da Cunha, Andre P.; Kuhn, Chantal; Rubino, Stephen; M'Hamdi, Hanane; Gabriely, Galina; Vandeventer, Tyler; Liu, Shirong; Cialic, Ron; Pinheiro-Rosa, Natalia; Oliveira, Rafael P.; Gaublomme, Jellert T.; Obholzer, Nikolaus; Kozubek, James; Pochet, Nathalie; Faria, Ana M. C.; Weiner, Howard L. (Nature Publishing Group, 2015)
      γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound ...
    • Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation 

      Mazzola, Maria Antonietta; Raheja, Radhika; Murugaiyan, Gopal; Rajabi, Hasan; Kumar, Deepak; Pertel, Thomas; Regev, Keren; Griffin, Russell; Aly, Lilian; Kivisakk, Pia; Nejad, Parham; Patel, Bonny; Gwanyalla, Nguendab; Hei, Hillary; Glanz, Bonnie; Chitnis, Tanuja; Weiner, Howard L.; Gandhi, Roopali (BioMed Central, 2015)
      Background: Fingolimod (FTY720), the first oral treatment for multiple sclerosis (MS), blocks immune cell trafficking and prevents disease relapses by downregulation of sphingosine-1-phosphate receptor. We determined the ...
    • Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia 

      Butovsky, Oleg; Jedrychowski, Mark P.; Moore, Craig S.; Cialic, Ron; Lanser, Amanda J.; Gabriely, Galina; Koeglsperger, Thomas; Dake, Ben; Wu, Pauline M.; Doykan, Camille E.; Fanek, Zain; Liu, LiPing; Chen, Zhuoxun; Rothstein, Jeffrey D.; Ransohoff, Richard M.; Gygi, Steven P.; Antel, Jack P.; Weiner, Howard L. (2014)
      Microglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that ...
    • Identification of Cytolytic CD161\(^−\)CD56\(^+\) Regulatory CD8 T Cells in Human Peripheral Blood 

      Hu, Dan; Weiner, Howard L.; Ritz, Jerome (Public Library of Science, 2013)
      We previously developed methods for establishing CD8 regulatory T cell (Treg) clones from normal human peripheral blood and demonstrated that these clones were capable of killing T cell receptor (TCR)-activated autologous ...
    • IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation 

      Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf; Beynon, Vanessa; Yang, Zhiping; Alvarez, Jorge I.; Prat, Alexandre; Sobel, Raymond A.; Kobzik, Lester; Lassmann, Hans; Quintana, Francisco J.; Weiner, Howard L. (Oxford University Press, 2016)
      See Winger and Zamvil (doi:10.1093/brain/aww121) for a scientific commentary on this article. The innate immune system plays a central role in the chronic central nervous system inflammation that drives neurological ...
    • The Impact of Lesion In-Painting and Registration Methods on Voxel-Based Morphometry in Detecting Regional Cerebral Gray Matter Atrophy in Multiple Sclerosis 

      Ceccarelli, A.; Jackson, J. S.; Tauhid, S.; Arora, A; Gorky, J.; Dell, E.; Bakshi, A.; Chitnis, Tanuja; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit; Neema, Mohit (American Society of Neuroradiology (ASNR), 2012)
      Background and Purpose: VBM has been widely used to study GM atrophy in MS. MS lesions lead to segmentation and registration errors that may affect the reliability of VBM results. Improved segmentation and registration ...
    • Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium 

      Laurent, Louise C.; Abdel-Mageed, Asim B.; Adelson, P. David; Arango, Jorge; Balaj, Leonora; Breakefield, Xandra; Carlson, Elizabeth; Carter, Bob S.; Majem, Blanca; Chen, Clark C.; Cocucci, Emanuele; Danielson, Kirsty; Courtright, Amanda; Das, Saumya; Elmageed, Zakaria Y. Abd; Enderle, Daniel; Ezrin, Alan; Ferrer, Marc; Freedman, Jane; Galas, David; Gandhi, Roopali; Huentelman, Matthew J.; Van Keuren-Jensen, Kendall; Kalani, Yashar; Kim, Yong; Krichevsky, Anna M.; Lai, Charles; Lal-Nag, Madhu; Laurent, Clara D.; Leonardo, Trevor; Li, Feng; Malenica, Ivana; Mondal, Debasis; Nejad, Parham; Patel, Tushar; Raffai, Robert L.; Rubio, Renee; Skog, Johan; Spetzler, Robert; Sun, Jie; Tanriverdi, Kahraman; Vickers, Kasey; Wang, Liang; Wang, Yaoyu; Wei, Zhiyun; Weiner, Howard L.; Wong, David; Yan, Irene K.; Yeri, Ashish; Gould, Stephen (Co-Action Publishing, 2015)
      Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of the interest in ...