Now showing items 1-4 of 4

    • An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction 

      Zhu, Chen; Sakuishi, Kaori; Xiao, Sheng; Sun, Zhiyi; Zaghouani, Sarah; Gu, Guangxiang; Wang, Chao; Tan, Dewar J.; Wu, Chuan; Rangachari, Manu; Pertel, Thomas; Jin, Hyun-Tak; Ahmed, Rafi; Anderson, Ana C.; Kuchroo, Vijay K. (2015)
      SUMMARY The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive ...
    • Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 

      Wu, Chuan; Yosef, Nir; Thalhamer, Theresa; Zhu, Chen; Xiao, Sheng; Kishi, Yasuhiro; Regev, Aviv; Kuchroo, Vijay (2013)
      Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype ...
    • T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation 

      Yang, Jianjun; Zhang, Ruihua; Lu, Geming; Shen, Yu; Peng, Liang; Zhu, Chen; Cui, Miao; Wang, Weidong; Arnaboldi, Paul; Tang, Meng; Gupta, Monica; Qi, Chen-Feng; Jayaraman, Padmini; Zhu, Hongfa; Jiang, Bo; Chen, Shu-hsia; He, John Cijiang; Ting, Adrian T.; Zhou, Ming-Ming; Kuchroo, Vijay K.; Morse, Herbert C.; Ozato, Keiko; Sikora, Andrew G.; Xiong, Huabao (The Rockefeller University Press, 2013)
      RORγt is necessary for the generation of TH17 cells but the molecular mechanisms for the regulation of TH17 cells are still not fully understood. We show that activation of CD4+ T cells results in the expression of inducible ...
    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...