Now showing items 1-20 of 21

    • Activated mouse \(CD4^+Foxp3^−\) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity 

      Wang, Xiaojuan; Cui, Yanyan; Luo, Gaoxing; Wang, Qinghong; Hu, Jie; He, Weifeng; Yuan, Jun; Zhou, Junyi; Wu, Yan; Sun, Xiaofeng; Robson, Simon C; Li, Xianchang; Tan, Jiangling; Peng, Yanmeng; Xue, Gang; Lu, Linrong; Gao, Wenda; Wu, Jun (Nature Publishing Group, 2012)
      The regulatory activities of mouse \(CD^4+Foxp3^+\) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional \(CD4^+Foxp3^−\) T cells in the periphery are able to ...
    • Autoimmune Hepatitis: Clinical Review with Insights into the Purinergic Mechanism of Disease 

      Kapila, Nikhil; Higa, Jennifer T.; Longhi, Maria Serena; Robson, Simon C. (XIA & HE Publishing Ltd, 2013)
      Autoimmune hepatitis (AIH) is an important disorder that predominantly results in inflammatory liver disease in genetically predisposed women. The clinicopathological picture is characterized by symptoms associated with ...
    • CD39 and Control of Cellular Immune Responses 

      Dwyer, Karen M.; Deaglio, Silvia; Gao, Wenda; Friedman, David J.; Strom, Terry Barton; Robson, Simon Christopher (Springer Verlag, 2007)
      CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ...
    • CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection 

      Yoshida, Osamu; Dou, Lei; Kimura, Shoko; Yokota, Shinichiro; Isse, Kumiko; Robson, Simon C.; Geller, David A.; Thomson, Angus W. (2015)
      Adenosine triphosphate (ATP), an essential metabolic energy source, is released following cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate innate immune cells. The ectonucleotidase ...
    • CD39 Expression Identifies Terminally Exhausted CD8+ T Cells 

      Gupta, Prakash K.; Godec, Jernej; Wolski, David; Adland, Emily; Yates, Kathleen; Pauken, Kristen E.; Cosgrove, Cormac; Ledderose, Carola; Junger, Wolfgang G.; Robson, Simon C.; Wherry, E. John; Alter, Galit; Goulder, Philip J. R.; Klenerman, Paul; Sharpe, Arlene H.; Lauer, Georg M.; Haining, W. Nicholas (Public Library of Science, 2015)
      Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially ...
    • Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease 

      Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)
      Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ...
    • The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance 

      Robson, Simon Christopher; Sévigny, Jean; Zimmermann, Herbert (Springer Netherlands, 2006)
      Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and ...
    • Ectonucleotidases in Müller Glial Cells of the Rodent Retina: Involvement in Inhibition of Osmotic Cell Swelling 

      Iandiev, Ianors; Wurm, Antje; Pannicke, Thomas; Wiedemann, Peter; Reichenbach, Andreas; Robson, Simon Christopher; Zimmermann, Herbert; Bringmann, Andreas (Springer Netherlands, 2007)
      Extracellular nucleotides mediate glia-to-neuron signalling in the retina and are implicated in the volume regulation of retinal glial (Müller) cells under osmotic stress conditions. We investigated the expression and ...
    • Editorial 

      Robson, Simon Christopher; Zimmermann, Herbert (Springer Netherlands, 2006)
      "Make everything as simple as possible, but not simpler’’ - Albert Einstein. Nucleosides and nucleotides are primordial biological molecules derived from glycosylamines (comprising nucleobases and variably phosphorylated ...
    • Expression and Distribution of Ectonucleotidases in Mouse Urinary Bladder 

      Yu, Weiqun; Robson, Simon Christopher; Hill, Warren Gary (Public Library of Science, 2011)
      Background: Normal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling ...
    • Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease 

      Friedman, David J.; Talbert, Matthew E.; Bowden, Donald W.; Freedman, Barry I.; Mukanya, Yves; Enjyoji, Keiichi; Robson, Simon Christopher (American Diabetes Association, 2008)
      Objective: The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabetes ...
    • An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signaling 

      Wang, Yan; Telesford, Kiel M.; Ochoa-Repáraz, Javier; Haque-Begum, Sakhina; Christy, Marc; Kasper, Eli J.; Wang, Li; Wu, Yan; Robson, Simon C.; Kasper, Dennis L.; Kasper, Lloyd H. (2014)
      The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis. Intestinal ...
    • Lipoprotein metabolism in nonalcoholic fatty liver disease 

      Jiang, Zhenghui Gordon; Robson, Simon Christopher; Yao, Zemin (Editorial Department of Journal of Biomedical Research, 2013)
      Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver ...
    • Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study 

      Jiang, Zhenghui Gordon; Mukamal, Kenneth; Tapper, Elliot; Robson, Simon C.; Tsugawa, Yusuke (Public Library of Science, 2014)
      Background: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol (LDL-C) or low high-density lipoprotein cholesterol (HDL-C) levels, are associated with nonalcoholic fatty ...
    • Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells 

      Peng, Qiang; Yeh, Heidi; Wei, Lingling; Enjyoj, Keiichi; Machaidze, Zurab; Csizmad, Eva; Schuetz, Christian; Lee, Kang Mi; Deng, Shaoping; Robson, Simon Christopher; Markmann, James; Buhler, Leo (Public Library of Science, 2012)
      Background: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. ...
    • Mitochondrial recoupling: a novel therapeutic strategy for cancer? 

      Baffy, Gyorgy; Derdak, Z; Robson, Simon Christopher (Nature Publishing Group, 2011)
      Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, ...
    • NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine 

      Bai, Aiping; Moss, Alan; Rothweiler, Sonja; Serena Longhi, Maria; Wu, Yan; Junger, Wolfgang G.; Robson, Simon C. (Nature Pub. Group, 2015)
      Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells to generate Tc1 cells, not only increases IFNγ production ...
    • P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death 

      Bian, Shu; Sun, Xiaofeng; Bai, Aiping; Zhang, Chunqing; Li, Lingling; Enjoji, Keiichi; Junger, Wolfgang G; Robson, Simon Christopher; Wu, Yan (Public Library of Science, 2013)
      Background: Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported that chronic exposure of tumor ...
    • Prognostic significance of macrophage invasion in hilar cholangiocarcinoma 

      Atanasov, Georgi; Hau, Hans-Michael; Dietel, Corinna; Benzing, Christian; Krenzien, Felix; Brandl, Andreas; Wiltberger, Georg; Matia, Ivan; Prager, Isabel; Schierle, Katrin; Robson, Simon C.; Reutzel-Selke, Anja; Pratschke, Johann; Schmelzle, Moritz; Jonas, Sven (BioMed Central, 2015)
      Background: Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hilar ...
    • The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice 

      Chia, Joanne S.J.; McRae, Jennifer L.; Thomas, Helen E.; Fynch, Stacey; Elkerbout, Lorraine; Hill, Prue; Murray-Segal, Lisa; Robson, Simon C.; Chen, Jiang-Fan; d’Apice, Anthony J.F.; Cowan, Peter J.; Dwyer, Karen M. (American Diabetes Association, 2013)
      Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent diabetes. We investigated ...