Now showing items 1-2 of 2

    • Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish 

      Bruni, Giancarlo; Lakhani, Parth; Kokel, David (Frontiers Media S.A., 2014)
      Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based ...
    • Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds 

      Bruni, Giancarlo; Rennekamp, Andrew J.; Velenich, Andrea; McCarroll, Matthew; Gendelev, Leo; Fertsch, Ethan; Taylor, Jack; Lakhani, Parth; Lensen, Dennis; Evron, Tama; Lorello, Paul J.; Huang, Xi-Ping; Kolczewski, Sabine; Carey, Galen; Caldarone, Barbara J.; Prinssen, Eric; Roth, Bryan L.; Keiser, Michael J.; Peterson, Randall T.; Kokel, David (2016)
      Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping, and a large sampling of compounds, it should be possible to ...