Now showing items 1-8 of 8

    • CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway 

      Kometani, Kohei; Yamada, Takayuki; Sasaki, Yoshiteru; Yokosuka, Tadashi; Saito, Takashi; Rajewsky, Klaus; Ishiai, Masamichi; Hikida, Masaki; Kurosaki, Tomohiro (The Rockefeller University Press, 2011)
      CIN85 transduces B cell receptor signals to IKK-β, and its expression in B cells is essential for T cell–independent type II antibody responses in mice.
    • Constitutive CD40 Signaling in B Cells Selectively Activates the Noncanonical NF-κB Pathway and Promotes Lymphomagenesis 

      Hömig-Hölzel, Cornelia; Hojer, Caroline; Rastelli, Julia; Casola, Stefano; Strobl, Lothar J.; Müller, Werner; Quintanilla-Martinez, Leticia; Gewies, Andreas; Ruland, Jürgen; Zimber-Strobl, Ursula; Rajewsky, Klaus (The Rockefeller University Press, 2008)
      CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell–dependent immune responses. Because CD40 is widely expressed on the surface of tumor cells in various B cell malignancies, ...
    • Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory 

      Kaji, Tomohiro; Ishige, Akiko; Hikida, Masaki; Taka, Junko; Hijikata, Atsushi; Kubo, Masato; Nagashima, Takeshi; Takahashi, Yoshimasa; Kurosaki, Tomohiro; Okada, Mariko; Ohara, Osamu; Rajewsky, Klaus; Takemori, Toshitada (The Rockefeller University Press, 2012)
      One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell–dependent germinal center (GC) reaction. A puzzling ...
    • Generation of Mice with a Conditional Foxp2 Null Allele 

      French, Catherine A; Groszer, Matthias; Preece, Christopher; Coupe, Anne-Marie; Rajewsky, Klaus; Fisher, Simon E (Wiley-Blackwell, 2007)
      Disruptions of the human FOXP2 gene cause problems with articulation of complex speech sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 transcription factor is highly similar in humans ...
    • Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination 

      Wesemann, Duane Robert; Magee, Jennifer; Boboila, Cristian; Calado, Dinis Pedro; Gallagher, Michael P.; Portuguese, Andrew J.; Manis, John P.; Zhou, Xiaolong; Recher, Mike; Rajewsky, Klaus; Notarangelo, Luigi D.; Alt, Frederick W. (The Rockefeller University Press, 2011)
      Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 ...
    • Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching 

      Wang, Jing; Alt, Frederick W.; Gostissa, Monica; Datta, Abhishek; Murphy, Michael C.; Alimzhanov, Marat B.; Coakley, Kristen M.; Rajewsky, Klaus; Manis, John P.; Yan, Catherine T. (The Rockefeller University Press, 2008)
      Nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks (DSBs) during V(D)J recombination in developing lymphocytes and during immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) in peripheral ...
    • PLC-γ2 is Essential for Formation and Maintenance of Memory B Cells 

      Hikida, Masaki; Casola, Stefano; Takahashi, Noriko; Kaji, Tomohiro; Takemori, Toshitada; Rajewsky, Klaus; Kurosaki, Tomohiro (The Rockefeller University Press, 2009)
      Resting antigen-experienced memory B cells are thought to be responsible for the more rapid and robust antibody responses after antigen reencounter, which are the hallmark of memory humoral responses. The molecular basis ...
    • Polζ Ablation in B Cells Impairs the Germinal Center Reaction, Class Switch Recombination, DNA Break Repair, and Genome Stability 

      Schenten, Dominik; Kracker, Sven; Esposito, Gloria; Franco, Sonia; Klein, Ulf; Murphy, Michael C.; Alt, Frederick W.; Rajewsky, Klaus (Rockefeller University Press, 2009)
      Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand ...