Browsing by Author "Zheng, Carson"
Now showing items 1-5 of 5
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Apolipoprotein C-III and the Metabolic Basis for Hypertriglyceridemia and the Dense Low-Density Lipoprotein Phenotype
Zheng, Chunyu; Khoo, C.; Furtado, J.; Sacks, Frank Martin (Ovid Technologies (Wolters Kluwer Health), 2010)BACKGROUND: Here, we aim to identify defects of apolipoprotein (apo) B lipoprotein metabolism that characterize hypertriglyceridemia, focusing on apoC-III and apoE. METHODS AND RESULTS: We studied the transport of plasma ... -
Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation
Tang, E. H. C.; Shvartz, E.; Shimizu, K.; Rocha, V. Z.; Zheng, Chunyu; Fukuda, D.; Shi, Guo-Ping; Sukhova, Galina K.; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2010)Objective—To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. Methods and ... -
Rapid turnover of apolipoprotein C-III-containing triglyceride-rich lipoproteins contributing to the formation of LDL subfractions
Zheng, Chunyu; Khoo, C.; Ikewaki, K.; Sacks, Frank Martin (American Society for Biochemistry & Molecular Biology (ASBMB), 2007)The atherogenicity theory for triglyceride-rich lipoproteins (TRLs; VLDL + intermediate density lipoprotein) generally cites the action of apolipoprotein C-III (apoC-III), a component of some TRLs, to retard their metabolism ... -
Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo
Sacks, Frank Martin; Rudel, L. L.; Conner, A.; Akeefe, H.; Kostner, G.; Baki, T.; Rothblat, G.; de la Llera-Moya, M.; Asztalos, B.; Perlman, T.; Zheng, Chunyu; Alaupovic, P.; Maltais, J.-A. B.; Brewer, H. B. (American Society for Biochemistry & Molecular Biology (ASBMB), 2008)Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that ... -
Statins Suppress Apolipoprotein CIII-Induced Vascular Endothelial Cell Activation and Monocyte Adhesion
Zheng, Chunyu; Azcutia, Veronica; Aikawa, Elena; Figueiredo, Jose-Luiz; Croce, Kevin James; Sonoki, Hiroyuki; Sacks, Frank Martin; Luscinskas, Francis William; Aikawa, Masanori (Oxford University Press, 2012)Aims: Activation of vascular endothelial cells (ECs) contributes importantly to inflammation and atherogenesis. We previously reported that apolipoprotein CIII (apoCIII), found abundantly on circulating triglyceride-rich ...