Now showing items 1-9 of 9

    • Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5 

      Abedalthagafi, Malak S.; Merrill, Parker H.; Bi, Wenya Linda; Jones, Robert T.; Listewnik, Marc L.; Ramkissoon, Shakti H.; Thorner, Aaron R.; Dunn, Ian F.; Beroukhim, Rameen; Alexander, Brian M.; Brastianos, Priscilla K.; Francis, Joshua M.; Folkerth, Rebecca D.; Ligon, Keith L.; Hummelen, Paul Van; Ligon, Azra H.; Santagata, Sandro (Impact Journals LLC, 2014)
      Meningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World ...
    • BRAF V600E Mutations are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications 

      Lam, Quynh; Vernovsky, Kathy; Vena, Natalie; Lennerz, Jochen K.; Dias-Santagata, Dora; Borger, Darrell R.; Batchelor, Tracy Todd; Ligon, Keith Lloyd; Iafrate, Anthony John; Ligon, Azra Hadi; Louis, David Neil; Santagata, Sandro; Dias-Santagata, Dora (Public Library of Science, 2011)
      Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur within 10 years of primary resection. Upon recurrence, patients ...
    • CDK8 Is a Colorectal Cancer Oncogene That Regulates β-Catenin Activity 

      Firestein, Ron; Bass, Adam; Kim, So Young; Dunn, Ian Frederick; Silver, Serena J.; Guney, Isil; Freed, Ellen; Ligon, Azra Hadi; Vena, Natalie; Ogino, Shuji; Chheda, Milan; Tamayo, Pablo; Finn, Stephen; Shrestha, Yashaswi; Boehm, Jesse S.; Jain, Supriya Rani; Bojarski, Emeric; Mermel, Craig; Barretina, Jordi; Chan, Jennifer Ang; Baselga, Jose; Tabernero, Josep; Root, David E.; Fuchs, Charles Stewart; Loda, Massimo; Shivdasani, Ramesh Arjun; Meyerson, Matthew Langer; Hahn, William Chun (Springer Nature, 2008)
      Aberrant activation of the canonical Wnt/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity drives colon tumorigenesis, ...
    • Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases 

      Ni, Jing; Ramkissoon, Shakti H.; Xie, Shaozhen; Goel, Shom; Stover, Daniel G.; Guo, Hanbing; Luu, Victor; Marco, Eugenio; Ramkissoon, Lori A.; Kang, Yun Jee; Hayashi, Marika; Nguyen, Quang-De; Ligon, Azra H.; Du, Rose; Claus, Elizabeth B.; Alexander, Brian M.; Yuan, Guo-Cheng; Wang, Zhigang C.; Iglehart, J. Dirk; Krop, Ian E.; Roberts, Thomas M.; Winer, Eric P.; Lin, Nancy U.; Ligon, Keith L.; Zhao, Jean J. (2016)
      Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases ...
    • Complex cytogenetic rearrangements at the DURS1 locus in syndromic Duane retraction syndrome 

      Baris, Hagit N; Chan, Wai-Man; Andrews, Caroline; Behar, Doron M; Donovan, Diana J; Morton, Cynthia C; Ranells, Judith; Pal, Tuya; Ligon, Azra H; Engle, Elizabeth C (Blackwell Publishing Ltd, 2013)
      Key Clinical Message A patient with syndromic Duane retraction syndrome harbors a chromosome 811.1q13.2 inversion and 8p11.1-q12.3 marker chromosome containing subregions with differing mosaicism and allele frequencies. ...
    • Detection of ERBB2 Amplification in Uterine Serous Carcinoma by Next-Generation Sequencing: An Approach Highly Concordant With Standard Assays 

      Robinson, Carrie; Harrison, Beth; Ligon, Azra; Dong, Fei; Maffeis, Valeria; Matulonis, Ursula; Nucci, Marisa; Kolin, David L. (Springer Science and Business Media LLC, 2020-10-19)
      Uterine serous carcinoma is an aggressive subtype of endometrial cancer that accounts for fewer than 10% of endometrial carcinomas but is responsible for about half of deaths. A subset of cases has HER2 overexpression ...
    • DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues 

      Craig, Justin M.; Vena, Natalie; Idbaih, Ahmed; Fouse, Shaun D.; Ozek, Memet; Sav, Aydin; Margraf, Linda R.; Eberhart, Charles G.; Norden, Andrew D.; Ramkissoon, Shakti; Hill, D. Ashley; Kieran, Mark W.; Wen, Patrick Yung Chih; Loda, Massimo; Santagata, Sandro; Ligon, Keith Lloyd; Ligon, Azra Hadi (Public Library of Science, 2012)
      Whole-genome copy number analysis platforms, such as array comparative genomic hybridization (aCGH) and single nucleotide polymorphism (SNP) arrays, are transformative research discovery tools. In cancer, the identification ...
    • FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis 

      Levanon, Keren; Sapoznik, Stav; Bahar-Shany, Keren; Brand, Hadar; Shapira-Frommer, Ronnie; Korach, Jacob; Hirsch, Michelle S.; Roh, Michael H.; Miron, Alexander; Liu, Joyce F.; Vena, Natalie; Ligon, Azra H.; Fotheringham, Susan; Bailey, Dyane; Flavin, Richard J.; Birrer, Michael J.; Drapkin, Ronny I. (2014)
      Serous ovarian carcinoma is the most lethal gynecological malignancy in Western countries. The molecular events that underlie the development of the disease have been elusive for many years. The recent identification of ...
    • MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism 

      Bandopadhayay, Pratiti; Ramkissoon, Lori A.; Jain, Payal; Bergthold, Guillaume; Wala, Jeremiah; Zeid, Rhamy; Schumacher, Steven E.; Urbanski, Laura; O’Rourke, Ryan; Gibson, William J.; Pelton, Kristine; Ramkissoon, Shakti H.; Han, Harry J.; Zhu, Yuankun; Choudhari, Namrata; Silva, Amanda; Boucher, Katie; Henn, Rosemary E.; Kang, Yun Jee; Knoff, David; Paolella, Brenton R.; Gladden-Young, Adrianne; Varlet, Pascale; Pages, Melanie; Horowitz, Peleg M.; Federation, Alexander; Malkin, Hayley; Tracy, Adam; Seepo, Sara; Ducar, Matthew; Hummelen, Paul Van; Santi, Mariarita; Buccoliero, Anna Maria; Scagnet, Mirko; Bowers, Daniel C.; Giannini, Caterina; Puget, Stephanie; Hawkins, Cynthia; Tabori, Uri; Klekner, Almos; Bognar, Laszlo; Burger, Peter C.; Eberhart, Charles; Rodriguez, Fausto J.; Hill, D. Ashley; Mueller, Sabine; Haas-Kogan, Daphne A.; Phillips, Joanna J.; Santagata, Sandro; Stiles, Charles D.; Bradner, James E.; Jabado, Nada; Goren, Alon; Grill, Jacques; Ligon, Azra H.; Goumnerova, Liliana; Waanders, Angela J.; Storm, Phillip B.; Kieran, Mark W.; Ligon, Keith L.; Beroukhim, Rameen; Resnick, Adam C. (2016)
      Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs including 19 Angiocentric Gliomas. We identified ...