Browsing by Author "Siebert, Uwe"
Now showing items 1-14 of 14
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Antiviral Combination Therapy with Interferon/Peginterferon Plus Ribavirin for Patients with Chronic Hepatitis C in Germany: A Health Technology Assessment Commissioned by the German Agency for Health Technology Assessment
Sroczynski, Gaby; Siebert, Uwe; German Hepatitis C Model (GEHMO) Group; HTA Expert Panel on Hepatitis C (German Medical Science, 2003)Objective: The purpose of this health technology assessment (HTA), commissioned by the German Agency for HTA at the German Federal Ministry of Health and Social Security, was to systematically review the evidence on ... -
Assessing the Costs and Cost-Effectiveness of Genomic Sequencing
Christensen, Kurt D.; Dukhovny, Dmitry; Siebert, Uwe; Green, Robert C. (MDPI, 2015)Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview ... -
Breast Cancer Incidence and Mortality in Tyrol/Austria after Fifteen Years of Opportunistic Mammography Screening
Oberaigner, Willi; Buchberger, Wolfgang; Frede, Thomas; Knapp, Rudolf; Marth, Christian; Siebert, Uwe (BioMed Central, 2010)Background: The aim of this study was to analyse breast cancer incidence and mortality in Tyrol from 1970 to 2006, namely after performing more than a decade of opportunistic mammography screening and just before piloting ... -
COMMUNICATING THE PARAMETER UNCERTAINTY IN THE IQWIG EFFICIENCY FRONTIER TO DECISION-MAKERS
Stollenwerk, Björn; Lhachimi, Stefan K; Briggs, Andrew; Fenwick, Elisabeth; Caro, Jaime J; Siebert, Uwe; Danner, Marion; Gerber-Grote, Andreas (John Wiley & Sons, Ltd, 2014)The Institute for Quality and Efficiency in Health Care (IQWiG) developed—in a consultation process with an international expert panel—the efficiency frontier (EF) approach to satisfy a range of legal requirements for ... -
Comparing the Clinical Effectiveness of Different New-Born Hearing Screening Strategies. A Decision Analysis
Grill, Eva; Hessel, Franz; Siebert, Uwe; Schnell-Inderst, Petra; Kunze, Silke; Nickisch, Andreas; Wasem, Jürgen (BioMed Central, 2005)Background: Children with congenital hearing impairment benefit from early detection and treatment. At present, no model exists which explicitly quantifies the effectiveness of universal newborn hearing screening (UNHS) ... -
Economic Evaluation of Newborn Hearing Screening: Modelling Costs and Outcomes
Hessel, Franz; Grill, Eva; Schnell-Inderst, Petra; Siebert, Uwe; Kunze, Silke; Nickisch, Andreas; von Voß, Hubertus; Wasem, Jürgen (German Medical Science, 2003)Objectives: The prevalence of newborn hearing disorders is 1-3 per 1,000. Crucial for later outcome are correct diagnosis and effective treatment as soon as possible. With BERA and TEOAE low-risk techniques for early ... -
Effectiveness and Cost-Effectiveness of Sequential Treatment of Patients with Chronic Myeloid Leukemia in the United States: A Decision Analysis
Rochau, Ursula; Kluibenschaedl, Martina; Stenehjem, David; Kuan-Ling, Kuo; Radich, Jerald; Oderda, Gary; Brixner, Diana; Siebert, Uwe (Hindawi Publishing Corporation, 2015)Currently several tyrosine kinase inhibitors (TKIs) are approved for treatment of chronic myeloid leukemia (CML). Our goal was to identify the optimal sequential treatment strategy in terms of effectiveness and cost-effectiveness ... -
HCV-Related Burden of Disease in Europe: A Systematic Assessment of Incidence, Prevalence, Morbidity, and Mortality
Mühlberger, Nikolai; Schwarzer, Ruth; Lettmeier, Beate; Sroczynski, Gaby; Zeuzem, Stefan; Siebert, Uwe (BioMed Central, 2009)Background: Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by the virus. We summarised burden of disease ... -
Introduction of organised mammography screening in tyrol: results of a one-year pilot phase
Oberaigner, Willi; Buchberger, Wolfgang; Frede, Thomas; Daniaux, Martin; Knapp, Rudolf; Marth, Christian; Siebert, Uwe (BioMed Central, 2011)Background: Efficiency and efficacy of organised mammography screening programs have been proven in large randomised trials. But every local implementation of mammography screening has to check whether the well established ... -
Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson’s disease
Dams, Judith; Klotsche, Jens; Bornschein, Bernhard; Reese, Jens P; Balzer-Geldsetzer, Monika; Winter, Yaroslav; Schrag, Anette; Siderowf, Andrew; Oertel, Wolfgang H; Deuschl, Günther; Siebert, Uwe; Dodel, Richard (BioMed Central, 2013)Background: Clinical studies employ the Unified Parkinson’s Disease Rating Scale (UPDRS) to measure the severity of Parkinson’s disease. Evaluations often fail to consider the health-related quality of life (HrQoL) or apply ... -
Prostate-Specific Antigen Testing in Tyrol, Austria: Prostate Cancer Mortality Reduction Was Supported by an Update with Mortality Data up to 2008
Oberaigner, Willi; Siebert, Uwe; Horninger, Wolfgang; Klocker, Helmut; Bektic, Jasmin; Schäfer, Georg; Frauscher, Ferdinand; Schennach, Harald; Bartsch, Georg (SP Birkhäuser Verlag Basel, 2012)Objectives: The objective of this study was to update an in-depth analysis of the time trend for prostate cancer (PCA) mortality in the population of Tyrol by 5 years, namely to 2008. In Tyrol, prostate-specific antigen ... -
Real-World Use of 3rd Line Therapy for Multiple Myeloma in Austria: An Austrian Myeloma Registry (AMR) Analysis of the Therapeutic Landscape and Clinical Outcomes prior to the Use of Next Generation Myeloma Therapeutics
Willenbacher, Ella; Weger, Roman; Rochau, Ursula; Siebert, Uwe; Willenbacher, Wolfgang (Public Library of Science, 2016)Objective: Clinical trials demonstrate improving survival in patients with multiple myeloma (MM) after treatment. However, it is unclear whether increased survival translates to a similar benefit in a real world setting. ... -
Recall Responses to Tetanus and Diphtheria Vaccination Are Frequently Insufficient in Elderly Persons
Weinberger, Birgit; Schirmer, Michael; Matteucci Gothe, Raffaella; Siebert, Uwe; Fuchs, Dietmar; Grubeck-Loebenstein, Beatrix (Public Library of Science, 2013)Demographic changes and a more active life-style in older age have contributed to an increasing public awareness of the need for lifelong vaccination. Currently many older persons have been vaccinated against selected ... -
Time-to-event versus ten-year-absolute-risk in cardiovascular risk prevention – does it make a difference? Results from the Optimizing-Risk-Communication (OptRisk) randomized-controlled trial
Adarkwah, Charles Christian; Jegan, Nikita; Heinzel-Gutenbrunner, Monika; Kühne, Felicitas; Siebert, Uwe; Popert, Uwe; Donner-Banzhoff, Norbert; Kürwitz, Sarah (BioMed Central, 2016)Background: The concept of shared-decision-making is a well-established approach to increase the participation of patients in medical decisions. Using lifetime risk or time-to-event (TTE) formats has been increasingly ...