Browsing by Author "Klagsbrun, Michael"
Now showing items 1-9 of 9
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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Adapala, Ravi K.; Thoppil, Roslin J.; Ghosh, Kaustabh; Cappelli, Holly; Dudley, Andrew C.; Paruchuri, Sailaja; Keshamouni, Venkateshwar; Klagsbrun, Michael; Meszaros, J. Gary; Chilian, William M.; Ingber, Donald E.; Thodeti, Charles K. (2016)Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor ... -
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities
D'Amore, Patricia Ann; Klagsbrun, Michael (Rockefeller University Press, 1984)Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ... -
Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus
Shim, Joon W.; Sandlund, Johanna; Hameed, Mustafa Q.; Blazer-Yost, Bonnie; Zhou, Feng C.; Klagsbrun, Michael; Madsen, Joseph R. (Nature Publishing Group, 2016)Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence ... -
The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis
Hofmann, Nicole A; Yang, Jiang; Trauger, Sunia A; Nakayama, Hironao; Huang, Lan; Strunk, Dirk; Moses, Marsha A; Klagsbrun, Michael; Bischoff, Joyce; Graier, Wolfgang F (John Wiley & Sons, Ltd, 2015)Background and Purpose Highly vascularized ovarian carcinoma secretes the putative endocannabinoid and GPR55 agonist, L-α-lysophosphatidylinositol (LPI), into the circulation. We aimed to assess the involvement of this ... -
Purification and characterization of heparin-binding endothelial cell growth factors.
Lobb, Roy; Sasse, Joachim; Sullivan, Robert; Shing, Yuen; D'Amore, Patricia Ann; Jacobs, Jeffrey; Klagsbrun, Michael (American Society for Biochemistry and Molecular Biology, 1986) -
Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo
Nakayama, Hironao; Bruneau, Sarah; Kochupurakkal, Nora; Coma, Silvia; Briscoe, David M.; Klagsbrun, Michael (Nature Publishing Group, 2015)Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its ... -
Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration
Panigrahy, Dipak; Adini, Irit; Mamluk, Roni; Levonyak, Nicholas; Bruns, Christiane J.; D'Amore, Patricia Ann; Klagsbrun, Michael; Bielenberg, Diane (Elsevier BV, 2014)Neuropilin-1 (NRP1) is a receptor for vascular endothelial growth factor (VEGF). A soluble isoform of Nrp1 (sNrp1) has not been described in the mouse. Our goal was to examine the expression of mouse sNrp1 during liver ... -
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription
Gerald, Damien; Adini, Irit; Shechter, Sharon; Perruzzi, Carole; Varnau, Joseph; Hopkins, Benjamin; Kazerounian, Shiva; Kurschat, Peter; Blachon, Stephanie; Khedkar, Santosh; Bagchi, Mandrita; Sherris, David; Prendergast, George C.; Klagsbrun, Michael; Stuhlmann, Heidi; Rigby, Alan C.; Nagy, Janice A.; Benjamin, Laura E. (Nature Pub. Group, 2013)Mechanisms governing the distinct temporal dynamics that characterize post-natal angiogenesis and lymphangiogenesis elicited by cutaneous wounds and inflammation remain unclear. RhoB, a stress-induced small GTPase, modulates ... -
VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells
Yoshida, Ayumi; Shimizu, Akio; Asano, Hirotsugu; Kadonosono, Tetsuya; Kondoh, Shinae Kizaka; Geretti, Elena; Mammoto, Akiko; Klagsbrun, Michael; Seo, Misuzu Kurokawa (The Company of Biologists, 2015)ABSTRACT Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 suppressed ...