Browsing by Author "Ayroles, Julien"

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    • Genetic incompatibilities are widespread within species 

      Corbett-Detig, Russell B.; Zhou, Jun; Clark, Andrew G.; Hartl, Daniel L.; Ayroles, Julien (Nature Publishing Group, 2013)
      The importance of epistasis—non-additive interactions between alleles—in shaping population fitness has long been a controversial topic, hampered in part by lack of empirical evidence1, 2, 3, 4. Traditionally, epistasis ...

    • Genomic Variation and Its Impact on Gene Expression in Drosophila Melanogaster 

      Massouras, Andreas; Waszak, Sebastian M.; Albarca-Aguilera, Monica; Hens, Korneel; Holcombe, Wiebke; Ayroles, Julien; Dermitzakis, Emmanouil T.; Stone, Eric A.; Jensen, Jeffrey D.; Mackay, Trudy F. C.; Deplancke, Bart (Public Library of Science, 2012)
      Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model ...

    • Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster 

      Ober, Ulrike; Stone, Eric A.; Richards, Stephen; Zhu, Dianhui; Gibbs, Richard A.; Stricker, Christian; Gianola, Daniel; Schlather, Martin; Mackay, Trudy F. C.; Simianer, Henner; Ayroles, Julien (Public Library of Science, 2012)
      Predicting organismal phenotypes from genotype data is important for plant and animal breeding, medicine, and evolutionary biology. Genomic-based phenotype prediction has been applied for single-nucleotide polymorphism ...