Now showing items 1-17 of 17

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...
    • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

      Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...
    • Associations between outdoor temperature and markers of inflammation: a cohort study 

      Halonen, Jaana I; Zanobetti, Antonella; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (BioMed Central, 2010)
      Background: Associations between ambient temperature and cardiovascular mortality are well established. This study investigated whether inflammation could be part of the mechanism leading to temperature-related cardiovascular ...
    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...
    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...
    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...
    • Effect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactions 

      Ren, Cizao; Vokonas, Pantel S; Suh MacIntosh, Helen H.; Fang, Shona C.; Christiani, David C.; Schwartz, Joel David (BioMed Central, 2010)
      Background: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ...
    • Effects of air pollution on heart rate variability: the VA Normative Aging Study 

      O’Neill, Marie S.; Park, Sung Kyun; Vokonas, Pantel S; Sparrow, David; Schwartz, Joel David (National Institue of Environmental Health Sciences, 2004)
      Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM\(_{2.5}\))]. We examined ...
    • Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval 

      Park, Sung Kyun; Hu, Howard; Wright, Robert O.; Schwartz, Joel David; Cheng, Yawen; Sparrow, David; Vokonas, Pantel S; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2008)
      Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...
    • Lead Concentrations in Relation to Multiple Biomarkers of Cardiovascular Disease: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; Ikeda, Ai; Fang, Shona C.; Sparrow, David; Weisskopf, Marc G.; Wright, Robert O.; Vokonas, Pantel S; Hu, Howard; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between ...
    • Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study 

      Jain, Nitin; Potula, Vijayalakshmi; Schwartz, Joel David; Vokonas, Pantel S; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone ...
    • Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study 

      Park, Sung Kyun; Schwartz, Joel David; Weisskopf, Marc G.; Sparrow, David; Vokonas, Pantel S; Wright, Robert O.; Coull, Brent Andrew; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006)
      Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ...
    • Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function 

      Alexeeff, Stacey E.; Coull, Brent Andrew; Gryparis, Alexandros; Suh, Helen; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2011)
      Background: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. Objectives: We examined the association between ...
    • Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort 

      Chahine, Teresa; Baccarelli, Andrea; Litonjua, Augusto Ampil; Wright, Robert O.; Suh MacIntosh, Helen H.; Gold, Diane R.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)
      Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ...
    • Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter 

      Wilker, Elissa Hope; Mittleman, Murray A.; Litonjua, Augusto Ampil; Poon, Audrey; Baccarelli, Andrea; Suh, Helen; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ...
    • Residential Black Carbon Exposure and Circulating Markers of Systemic Inflammation in Elderly Males: The Normative Aging Study 

      Fang, Shona C.; Mehta, Amar Jayant; Alexeeff, Stacey E.; Gryparis, Alexandros; Coull, Brent Andrew; Vokonas, Pantel S.; Christiani, David C.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role. Objectives: We conducted a repeated ...