Browsing by Author "Rotenberg, Alexander"
Now showing items 1-15 of 15
-
Aberrant Brain Plasticity in Autism Spectrum Disorders
Oberman, Lindsay M.; Rotenberg, Alexander; Pascual-Leone, Alvaro (Oxford University Press, 2014)Plasticity enables the human brain to adapt to developmental challenges and rapidly changing environmental demands, acquire new skills, and cope with injury. However, aberrant or mistimed brain plasticity can lead to ... -
Acute seizure suppression by transcranial direct current stimulation in rats
Dhamne, Sameer C; Ekstein, Dana; Zhuo, Zhihong; Gersner, Roman; Zurakowski, David; Loddenkemper, Tobias; Pascual-Leone, Alvaro; Jensen, Frances E; Rotenberg, Alexander (John Wiley & Sons, Ltd, 2015)Objective: Cathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic ... -
Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures
Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ... -
Characterizing and Modulating Brain Circuitry through Transcranial Magnetic Stimulation Combined with Electroencephalography
Farzan, Faranak; Vernet, Marine; Shafi, Mouhsin M. D.; Rotenberg, Alexander; Daskalakis, Zafiris J.; Pascual-Leone, Alvaro (Frontiers Media S.A., 2016)The concurrent combination of transcranial magnetic stimulation (TMS) with electroencephalography (TMS-EEG) is a powerful technology for characterizing and modulating brain networks across developmental, behavioral, and ... -
cis p-tau: early driver of brain injury and tauopathy blocked by antibody
Kondo, Asami; Shahpasand, Koorosh; Mannix, Rebekah; Qiu, Jianhua; Moncaster, Juliet; Chen, Chun-Hau; Yao, Yandan; Lin, Yu-Min; Driver, Jane A; Sun, Yan; Wei, Shuo; Luo, Man-Li; Albayram, Onder; Huang, Pengyu; Rotenberg, Alexander; Ryo, Akihide; Goldstein, Lee E; Pascual-Leone, Alvaro; McKee, Ann C.; Meehan, William; Zhou, Xiao Zhen; Lu, Kun Ping (2015)Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD), whose defining ... -
Construction and Evaluation of Rodent-Specific rTMS Coils
Tang, Alexander D.; Lowe, Andrea S.; Garrett, Andrew R.; Woodward, Robert; Bennett, William; Canty, Alison J.; Garry, Michael I.; Hinder, Mark R.; Summers, Jeffery J.; Gersner, Roman; Rotenberg, Alexander; Thickbroom, Gary; Walton, Joseph; Rodger, Jennifer (Frontiers Media S.A., 2016)Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been ... -
Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management
Sánchez Fernández, Iván; Chapman, Kevin E.; Peters, Jurriaan M.; Harini, Chellamani; Rotenberg, Alexander; Loddenkemper, Tobias (Hindawi Publishing Corporation, 2013)Continuous spikes and waves during sleep (CSWS) is an epileptic encephalopathy characterized in most patients by (1) difficult to control seizures, (2) interictal epileptiform activity that becomes prominent during sleep ... -
Corticosteroid therapy in regressive autism: a retrospective study of effects on the Frequency Modulated Auditory Evoked Response (FMAER), language, and behavior
Duffy, Frank H; Shankardass, Aditi; McAnulty, Gloria B; Eksioglu, Yaman Z; Coulter, David; Rotenberg, Alexander; Als, Heidelise (BioMed Central, 2014)Background: Up to a third of children with Autism Spectrum Disorder (ASD) manifest regressive autism (R-ASD).They show normal early development followed by loss of language and social skills. Absent evidence-based therapies, ... -
The frequency modulated auditory evoked response (FMAER), a technical advance for study of childhood language disorders: cortical source localization and selected case studies
Duffy, Frank H; Eksioglu, Yaman Z; Rotenberg, Alexander; Madsen, Joseph R; Shankardass, Aditi; Als, Heidelise (BioMed Central, 2013)Background: Language comprehension requires decoding of complex, rapidly changing speech streams. Detecting changes of frequency modulation (FM) within speech is hypothesized as essential for accurate phoneme detection, ... -
Microarray Noninvasive Neuronal Seizure Recordings from Intact Larval Zebrafish
Meyer, Michaela; Dhamne, Sameer C.; LaCoursiere, Christopher M.; Tambunan, Dimira; Poduri, Annapurna; Rotenberg, Alexander (Public Library of Science, 2016)Zebrafish epilepsy models are emerging tools in experimental epilepsy. Zebrafish larvae, in particular, are advantageous because they can be easily genetically altered and used for developmental and drug studies since ... -
Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder
Oberman, Lindsay M.; Pascual-Leone, Alvaro; Rotenberg, Alexander (Frontiers Media S.A., 2014)The developmental pathophysiology of autism spectrum disorders (ASD) is currently not fully understood. However, multiple lines of evidence suggest that the behavioral phenotype may result from dysfunctional inhibitory ... -
N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth
Gonzalez-Heydrich, Joseph; Bosquet Enlow, Michelle; D'Angelo, Eugene; Seidman, Larry J.; Gumlak, Sarah; Kim, April; Woodberry, Kristen A.; Rober, Ashley; Tembulkar, Sahil; O'Donnell, Kyle; Hamoda, Hesham M.; Kimball, Kara; Rotenberg, Alexander; Oberman, Lindsay M.; Pascual-Leone, Alvaro; Keshavan, Matcheri S.; Duffy, Frank H. (Hindawi Publishing Corporation, 2016)Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance ... -
Neurophysiological differences between patients clinically at high risk for schizophrenia and neurotypical controls – first steps in development of a biomarker
Duffy, Frank H.; D’Angelo, Eugene; Rotenberg, Alexander; Gonzalez-Heydrich, Joseph (BioMed Central, 2015)Background: Schizophrenia is a severe, disabling and prevalent mental disorder without cure and with a variable, incomplete pharmacotherapeutic response. Prior to onset in adolescence or young adulthood a prodromal period ... -
Suppression of Motor Cortical Excitability in Anesthetized Rats by Low Frequency Repetitive Transcranial Magnetic Stimulation
Muller, Paul A.; Dhamne, Sameer C.; Vahabzadeh-Hagh, Andrew M.; Pascual-Leone, Alvaro; Jensen, Frances E.; Rotenberg, Alexander (Public Library of Science, 2014)Repetitive transcranial magnetic stimulation (rTMS) is a widely-used method for modulating cortical excitability in humans, by mechanisms thought to involve use-dependent synaptic plasticity. For example, when low frequency ... -
Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders
Oberman, Lindsay M.; Rotenberg, Alexander; Pascual-Leone, Alvaro (Springer Science + Business Media, 2013)The clinical, social and financial burden of autism spectrum disorder (ASD) is staggering. We urgently need valid and reliable biomarkers for diagnosis and effective treatments targeting the often debilitating symptoms. ...