Browsing by Author "Picard, Michael"

Now showing items 1-20 of 36

    • Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: Results from the North American Multidisciplinary Study 

      Marcus, Frank I.; Zareba, Wojciech; Calkins, Hugh; Towbin, Jeffrey A.; Basso, Cristina; Bluemke, David A.; Estes, N.A. Mark; Picard, Michael Howard; Sanborn, Danita M. Yoerger; Thiene, Gaetano; Wichter, Thomas; Cannom, David; Wilber, David J.; Scheinman, Melvin; Duff, Henry; Daubert, James; Talajic, Mario; Krahn, Andrew; Sweeney, Michael Owen; Garan, Hasan; Sakaguchi, Scott; Lerman, Bruce B.; Kerr, Charles; Kron, Jack; Steinberg, Jonathan S.; Sherrill, Duane; Gear, Kathleen; Brown, Mary; Severski, Patricia; Polonsky, Slava; McNitt, Scott (Elsevier BV, 2009)
      Background: Prior reports on patients with ARVC/D focused on individuals with advanced forms of the disease. There are limited data regarding diagnostic performance of various testing modalities in newly identified individuals ...

    • Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab 

      Sawaya, H.; Sebag, I. A.; Plana, J. C.; Januzzi, James Louis; Ky, B.; Tan, T. C.; Cohen, V.; Banchs, J.; Carver, J. R.; Wiegers, S. E.; Martin, R. P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, E; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and ...

    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...

    • Case 40-2010 — A 68-Year-Old Woman with Chest Pain during an Airplane Flight 

      Picard, Michael Howard; Rosenfield, Kenneth; Digumarthy, Subba Rao; Smith, Rex Neal (New England Journal of Medicine (NEJM/MMS), 2010)
      A 68-year-old woman was transferred to this hospital because of substernal chest pain. An ECG showed evidence of MI. Coronary angiography was performed, with stenting of an occluded coronary artery. On the fourth hospital ...

    • Characteristics of Responders to Cardiac Resynchronization Therapy: The Impact of Echocardiographic Left Ventricular Volume 

      Park, Mi Young; Altman, Robert K.; Orencole, Mary; Kumar, Prabhat; Parks, Kimberly Ann; Heist, Kevin E.; Singh, Jagmeet P.; Picard, Michael Howard (Wiley-Blackwell, 2012)
      Background: One third of patients who receive cardiac resynchronization therapy (CRT) are classified as nonresponders. Characteristics of responders to CRT have been studied in multiple clinical trials. Hypothesis: We aimed ...

    • Comparative Definitions for Moderate-Severe Ischemia in Stress Nuclear, Echocardiography, and Magnetic Resonance Imaging 

      Shaw, Leslee J.; Berman, Daniel S.; Picard, Michael Howard; Friedrich, Matthias G.; Kwong, Raymond Yan-Kit; Stone, Gregg W.; Senior, Roxy; Min, James K.; Hachamovitch, Rory; Scherrer-Crosbie, Marielle; Mieres, Jennifer H.; Marwick, Thomas H.; Phillips, Lawrence M.; Chaudhry, Farooq A.; Pellikka, Patricia A.; Slomka, Piotr; Arai, Andrew E.; Iskandrian, Ami E.; Bateman, Timothy M.; Heller, Gary V.; Miller, Todd D.; Nagel, Eike; Goyal, Abhinav; Borges-Neto, Salvador; Boden, William E.; Reynolds, Harmony R.; Hochman, Judith S.; Maron, David J.; Douglas, Pamela S. (Elsevier BV, 2014)
      The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary ...

    • Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria 

      Marcus, F. I.; McKenna, William; Sherrill, D.; Basso, C.; Bauce, B.; Bluemke, D. A.; Calkins, H.; Corrado, D.; Cox, M. G. P. J.; Daubert, J. P.; Fontaine, G.; Gear, K.; Hauer, R.; Nava, A.; Picard, Michael Howard; Protonotarios, N.; Saffitz, Jeffrey E; Sanborn, Danita M. Yoerger; Steinberg, J. S.; Tandri, H.; Thiene, G.; Towbin, J. A.; Tsatsopoulou, A.; Wichter, T.; Zareba, W. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: In 1994, an International Task Force proposed criteria for the clinical diagnosis of ARVC/D which facilitated recognition and interpretation of the frequently non-specific clinical features of ARVC/D. This ...

    • Does Ischemia Burden in Stable Coronary Artery Disease Effectively Identify Revascularization Candidates?: Ischemia Burden in Stable Coronary Artery Disease Does Not Effectively Identify Revascularization Candidates 

      Reynolds, H. R.; Picard, Michael Howard; Hochman, J. S. (Ovid Technologies (Wolters Kluwer Health), 2015)

    • Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients 

      Sawaya, Heloisa; Sebag, Igal A.; Plana, Juan Carlos; Januzzi, James Louis; Ky, Bonnie; Cohen, Victor; Gosavi, Sucheta; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ...

    • Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab 

      Ky, Bonnie; Putt, Mary; Sawaya, Heloisa; French, Benjamin; Januzzi, James Louis; Sebag, Igal A.; Plana, Juan Carlos; Cohen, Victor; Banchs, Jose; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2014)
      Objectives: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. Background: Current methods to identify ...

    • Early Repolarization Pattern in Competitive Athletes: Clinical Correlates and the Effects of Exercise Training 

      Noseworthy, P. A.; Weiner, Rory Brett; Kim, J.; Keelara, V.; Wang, Francis; Berkstresser, B.; Wood, Malissa Jane; Wang, Thomas J.; Picard, Michael Howard; Hutter, Adolph Matthew; Newton-Cheh, Christopher Holmes; Baggish, Aaron L. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Inferior lead early repolarization pattern (ERP) has recently been associated with sudden cardiac death. Although ERP is common among athletes, prevalence, ECG lead distribution, clinical characteristics, and ...

    • Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock 

      Hochman, Judith S.; Sleeper, Lynn A.; Webb, John G.; Sanborn, Timothy A.; White, Harvey D.; Talley, J. David; Buller, Christopher E.; Jacobs, Alice K.; Slater, James N.; Col, Jacques; McKinlay, Sonja M.; Picard, Michael Howard; Menegus, Mark A.; Boland, Jean; Dzavik, Vladimir; Thompson, Christopher R.; Wong, S. Chiu; Steingart, Richard; Forman, Robert; Aylward, Philip E.; Godfrey, Emilie; Desvigne-Nickens, Patrice; LeJemtel, Thierry H. (New England Journal of Medicine (NEJM/MMS), 1999)
      Background The leading cause of death in patients hospitalized for acute myocardial infarction is cardiogenic shock. We conducted a randomized trial to evaluate early revascularization in patients with cardiogenic shock. ...

    • Growth hormone status predicts left ventricular mass in patients after cure of acromegaly 

      Wexler, Tamara; Durst, Ronen; McCarty, David; Picard, Michael Howard; Gunnell, Lindsay; Omer, Zehra; Fazeli, Pouneh Khadejeh; Miller, Karen Klahr; Klibanski, Anne (Elsevier BV, 2010)
      Context: Growth hormone excess and growth hormone deficiency (GHD) are both associated with increased cardiovascular morbidity. A specific acromegaly-related cardiomyopathy has been described, characterized in part by ...

    • Heart of Darkness: The Downside of Trastuzumab 

      Hayes, D. F.; Picard, Michael Howard (American Society of Clinical Oncology (ASCO), 2006)
      Trastuzumab has been shown to be quite effective in reducing suffering and mortality from breast cancer in both the metastatic and adjuvant settings. With short follow-up, remarkably consistent results across five adjuvant, ...

    • In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice 

      Baron, David M.; Clerte, Maeva; Brouckaert, Peter; Raher, Michael J.; Flynn, Aidan W.; Zhang, Haihua; Carter, Edward Albert; Picard, Michael Howard; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background—Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these ...

    • Leaflet Area as a Determinant of Tricuspid Regurgitation Severity in Patients With Pulmonary Hypertension 

      Afilalo, J.; Grapsa, J.; Nihoyannopoulos, P.; Beaudoin, J.; Gibbs, J. S. R.; Channick, Richard Neil; Langleben, D.; Rudski, L. G.; Hua, L.; Handschumacher, M. D.; Picard, Michael Howard; Levine, Robert A. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background: Tricuspid regurgitation (TR) is a risk factor for mortality in pulmonary hypertension (PH). TR severity varies among patients with comparable degrees of PH and right ventricular (RV) remodeling. The contribution ...

    • Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA 

      Phillips, Lawrence M.; Hachamovitch, Rory; Berman, Daniel S.; Iskandrian, Ami E.; Min, James K.; Picard, Michael Howard; Kwong, Raymond Yan-Kit; Friedrich, Matthias G.; Scherrer-Crosbie, Marielle; Hayes, Sean W.; Sharir, Tali; Gosselin, Gilbert; Mazzanti, Marco; Senior, Roxy; Beanlands, Rob; Smanio, Paola; Goyal, Abhi; Al-Mallah, Mouaz; Reynolds, Harmony; Stone, Gregg W.; Maron, David J.; Shaw, Leslee J. (Springer Science + Business Media, 2013)
      There is a preponderance of evidence that, in the setting of an acute coronary syndrome, an invasive approach using coronary revascularization has a morbidity and mortality benefit. However, recent stable ischemic heart ...

    • Long-Term Anabolic-Androgenic Steroid Use Is Associated With Left Ventricular Dysfunction 

      Baggish, Aaron L.; Weiner, Rory Brett; Kanayama, Gen; Hudson, James Irvin; Picard, Michael Howard; Hutter, Adolph Matthew; Pope, Harrison Graham (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: Although illicit anabolic-androgenic steroid (AAS) use is widespread, the cardiac effects of long-term AAS use remain inadequately characterized. We compared cardiac parameters in weightlifters reporting long-term ...

    • Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab 

      Putt, M.; Hahn, V. S.; Januzzi, James Louis; Sawaya, H.; Sebag, I. A.; Plana, J. C.; Picard, Michael Howard; Carver, J. R.; Halpern, E; Kuter, Irene; Passeri, Jonathan James; Cohen, V.; Banchs, J.; Martin, R. P.; Gerszten, Robert Edgardo; Scherrer-Crosbie, Marielle; Ky, B. (American Association for Clinical Chemistry (AACC), 2015)
      BACKGROUND: Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations ...

    • Mechanism of Decrease in Mitral Regurgitation After Cardiac Resynchronization Therapy: Optimization of the Force-Balance Relationship 

      Solis, J.; McCarty, D.; Levine, Robert A.; Handschumacher, M. D.; Fernandez-Friera, L.; Chen-Tournoux, A.; Mont, L.; Vidal, Barbara Crystal; Singh, Jagmeet P.; Brugada, J.; Picard, Michael Howard; Sitges, M.; Hung, Judy Weiming (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background: Cardiac resynchronization therapy (CRT) has been shown to reduce functional mitral regurgitation (MR). It has been proposed that the mechanism of MR reduction relates to geometric change or, alternatively, ...