Now showing items 1-7 of 7

    • Evolutionary Dynamics of a Multiple-Ploidy System in Arabidopsis Arenosa 

      Arnold, Brian (2015-05-18)
      Whole-genome duplication (WGD), which leads to polyploidy, has been implicated in speciation and biological novelty. In plants, many species have experienced historical bouts of WGD or exhibit extant ploidy variation, which ...
    • Extending Coalescent Theory to Autotetraploids 

      Arnold, Brian John; Bomblies, Kirsten; Wakeley, John (The Genetics Society of America, 2012)
      We develop coalescent models for autotetraploid species with tetrasomic inheritance. We show that the ancestral genetic process in a large population without recombination may be approximated using Kingman’s standard ...
    • Genetic Adaptation Associated with Genome-Doubling in Autotetraploid Arabidopsis arenosa 

      Hollister, Jesse D.; Arnold, Brian John; Svedin, Elisabeth; Xue, Katherine Shaohua; Dilkes, Brian P.; Bomblies, Kirsten (Public Library of Science, 2012)
      Genome duplication, which results in polyploidy, is disruptive to fundamental biological processes. Genome duplications occur spontaneously in a range of taxa and problems such as sterility, aneuploidy, and gene expression ...
    • The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome 

      Azarian, Taj; Grant, Lindsay R.; Arnold, Brian John; Hammitt, Laura L.; Reid, Raymond; Santosham, Mathuram; Weatherholtz, Robert; Goklish, Novalene; Thompson, Claudette M.; Bentley, Stephen D.; O’Brien, Katherine L.; Hanage, William P.; Lipsitch, Marc (Public Library of Science (PLoS), 2018)
      In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination ...
    • Meiotic Adaptation to Genome Duplication in Arabidopsis arenosa 

      Yant, Levi; Hollister, J; Wright, K; Arnold, Brian John; Higgins, James D.; Franklin, F. Chris H.; Bomblies, Kirsten (Elsevier BV, 2013)
      Whole genome duplication (WGD) is a major factor in the evolution of multicellular eukaryotes, yet by doubling the number of homologs, WGD severely challenges reliable chromosome segregation [1, 2, 3], a process conserved ...
    • RADseq underestimates diversity and introduces genealogical biases due to nonrandom haplotype sampling 

      Arnold, Brian John; Corbett-Detig, Russ Brendan; Hartl, Daniel L.; Bomblies, Kirsten (Wiley Blackwell (Blackwell Publishing), 2013)
      Reduced representation genome-sequencing approaches based on restriction digestion are enabling large-scale marker generation and facilitating genomic studies in a wide range of model and nonmodel systems. However, sampling ...
    • Weak Epistasis May Drive Adaptation in Recombining Bacteria 

      Arnold, Brian John; Gutmann, Michael U.; Grad, Yonatan Hagai; Sheppard, Samuel K.; Corander, Jukka; Lipsitch, Marc; Hanage, William P. (Genetics Society of America, 2018)
      The impact of epistasis on the evolution of multi-locus traits depends on recombination. While sexually reproducing eukaryotes recombine so frequently that epistasis between polymorphisms is not considered to play a large ...