Browsing by Author "Fukumura, Dai"

Now showing items 1-18 of 18

    • Arginine dependence of tumor cells: targeting a chink in cancer’s armor 

      Patil, M D; Bhaumik, J; Babykutty, S; Banerjee, U C; Fukumura, Dai (Springer Nature, 2016)
      Arginine, one among the twenty most common natural amino acids, plays a pivotal role in cellular physiology as it is being involved in numerous cellular metabolic and signaling pathways. Dependence on arginine is diverse ...

    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...

    • Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand 

      Liu, Wenhao; Greytak, Andrew B.; Lee, Jungmin; Wong, Cliff R.; Park, Jongnam; Marshall, Lisa F.; Jiang, Wen; Curtin, Peter N.; Ting, Alice Y.; Nocera, Daniel; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G. (American Chemical Society (ACS), 2010)
      We present a new class of polymeric ligands for quantum dot (QD) water solubilization to yield biocompatible and derivatizable QDs with compact size (~10-12 nm diameter), high quantum yields (>50%), excellent stability ...

    • Correlative intravital imaging of cGMP signals and vasodilation in mice 

      Thunemann, Martin; Schmidt, Kjestine; de Wit, Cor; Han, Xiaoxing; Jain, Rakesh K.; Fukumura, Dai; Feil, Robert (Frontiers Media S.A., 2014)
      Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation. ...

    • Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis 

      Choi, Jin Woo; Kim, Pilhan; Kim, Jun Ki; Kim, Yi Rang; Fukumura, Dai; Yun, Seok Hyun (Ivyspring International Publisher, 2015)
      Angiogenesis is essential for the progression of cancer, but its involvement in the initial phase of colon tumorigenesis is not well understood. Using intravital endomicroscopy, we visualized the natural history of early ...

    • Magneto-Fluorescent Core-Shell Supernanoparticles 

      Chen, Ou; Riedemann, Lars; Etoc, Fred; Herrmann, Hendrik; Coppey, Mathieu; Barch, Mariya; Farrar, Christian T.; Zhao, Jing; Bruns, Oliver T.; Wei, He; Guo, Peng; Cui, Jian; Jensen, Russ; Chen, Yue; Harris, Daniel K.; Cordero, Jose M.; Wang, Zhongwu; Jasanoff, Alan; Fukumura, Dai; Reimer, Rudolph; Dahan, Maxime; Jain, Rakesh K.; Bawendi, Moungi G. (2014)
      Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously ...

    • Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages 

      Incio, Joao; Suboj, Priya; Chin, Shan M.; Vardam-Kaur, Trupti; Liu, Hao; Hato, Tai; Babykutty, Suboj; Chen, Ivy; Deshpande, Vikram; Jain, Rakesh K.; Fukumura, Dai (Public Library of Science, 2015)
      Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated ...

    • Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies asin VivoTwo-Photon Oxygen Sensors 

      Lemon, Christopher M.; Karnas, Elizabeth; Han, Xiaoxing; Bruns, Oliver T.; Kempa, Thomas; Fukumura, Dai; Bawendi, Moungi G.; Jain, Rakesh K.; Duda, Dan Gabriel; Nocera, Daniel (American Chemical Society (ACS), 2015)
      Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O2 levels in aqueous media and in vivo. Förster resonance energy transfer from ...

    • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer 

      Whitley, Melodi; Cardona, Diana M.; Lazarides, Alexander; Spasojevic, Ivan; Ferrer, Jorge; Cahill, Joan; Lee, Chang-Lung; Snuderl, Matija; Blazer, Dan; Hwang, E. Shelley; Greenup, Rachel; Mosca, Paul; Mito, Jeffrey; Cuneo, Kyle C.; Larrier, Niole A.; OReilly, Erin K.; Riedel, Richard F.; Eward, William C.; Strasfeld, David B.; Fukumura, Dai; Jain, Rakesh K.; Lee, W. David; Griffith, Linda G.; Bawendi, Moungi G.; Kirsch, David G.; Brigman, Brian E. (American Association for the Advancement of Science (AAAS), 2016)
      Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical ...

    • NAD+ Mediated Rescue of Prenatal Forebrain Angiogenesis Restores Postnatal Behavior 

      Subburaju, Sivan; Kaye, Sarah; Choi, Yong Kee; Baruah, Jugajyoti; Datta, Debkanya; Ren, Jun; Kumar, Ashwin Srinivasan; Szabo, Gabor; Fukumura, Dai; Jain, Rakesh; ElKhal, Abdallah; Vasudevan, Anju (American Association for the Advancement of Science (AAAS), 2020-10-09)
      Intrinsic defects within blood vessels from the earliest developmental time points can directly contribute to psychiatric disease origin. Our work has shown that pre-formed vascular networks autonomously regulate key events ...

    • A Nanoparticle Size Series for In Vivo Fluorescence Imaging 

      Popovic, Zoran; Liu, Wenhao; Chauhan, Vikash Pal Singh; Lee, Jungmin; Wong, Cliff; Greytak, Andrew B.; Insin, Numpon; Nocera, Daniel; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G. (Wiley-Blackwell, 2010)

    • Next-generation in vivo optical imaging with short-wave infrared quantum dots 

      Bruns, Oliver T.; Bischof, Thomas S.; Harris, Daniel K.; Franke, Daniel; Shi, Yanxiang; Riedemann, Lars; Bartelt, Alexander; Jaworski, Frank B.; Carr, Jessica A.; Rowlands, Christopher J.; Wilson, Mark W. B.; Chen, Ou; Wei, He; Hwang, Gyu Weon; Montana, Daniel M.; Coropceanu, Igor; Achorn, Odin B.; Kloepper, Jonas; Heeren, Joerg; So, Peter T. C.; Fukumura, Dai; Jensen, Klavs F.; Jain, Rakesh K.; Bawendi, Moungi G. (Springer Nature, 2017)
      The short-wavelength infrared region (SWIR; 1000—2000 nm) provides several advantages over the visible and near-infrared regions for in vivo imaging. The general lack of autofluorescence, low light absorption by blood and ...

    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner 

      Chauhan, Vikash Pal Singh; Stylianopoulos, Triantafyllos; Martin, John D.; Popović, Zoran; Chen, Ou; Kamoun, Walid S.; Bawendi, Moungi G.; Fukumura, Dai; Jain, Rakesh K. (Springer Nature, 2012)
      The blood vessels of cancerous tumours are leaky1–3 and poorly organized4–7. This can increase the interstitial fluid pressure (IFP) inside tumours and reduce blood supply to them, which impairs drug delivery8–9. Anti-angiogenic ...

    • Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2 

      Incio, Joao; Ligibel, Jennifer A.; McManus, Daniel T.; Suboj, Priya; Jung, Keehoon; Kawaguchi, Kosuke; Pinter, Matthias; Babykutty, Suboj; Chin, Shan M.; Vardam, Trupti; Huang, Yuhui; Rahbari, Nuh N.; Roberge, Sylvie; Wang, Dannie; Gomes-Santos, Igor L.; Puchner, Stefan B.; Schlett, Christopher L.; Hoffmman, Udo; Ancukiewicz, Marek; Tolaney, Sara Michell; Krop, Ian Elliott; Duda, Dan Gabriel; Boucher, Yves; Fukumura, Dai; Jain, Rakesh K. (American Association for the Advancement of Science (AAAS), 2018)

    • Secreted Gaussia Luciferase as a Biomarker for Monitoring Tumor Progression and Treatment Response of Systemic Metastases 

      Chung, Euiheon; Yamashita, Hiroshi; Au, Patrick; Tannous, Bakhos A.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: Currently, only few techniques are available for quantifying systemic metastases in preclinical model. Thus techniques that can sensitively detect metastatic colonization and assess treatment response in real-time ...

    • Solid stress and elastic energy as measures of tumour mechanopathology 

      Nia, Hadi Tavakoli; Jain, Rakesh K.; Liu, Hao; Seano, Giorgio; Datta, Meenal; Jones, Dennis; Rahbari, Nuh; Incio, Joao; Chauhan, Vikash Pal Singh; Jung, Keehoon; Martin, John D.; Askoxylakis, Vasileios; Padera, Timothy P.; Fukumura, Dai; Boucher, Yves; Hornicek, Francis John; Grodzinsky, Alan J; Baish, James W; Munn, Lance Leon (Springer Nature, 2016)
      Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment. Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid stresses is challenging. Here, we show that ...

    • Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium 

      Seano, Giorgio; Nia, Hadi; Emblem, Kyrre E.; Datta, Meenal; Ren, Jun; Krishnan, Shanmugarajan; Kloepper, Jonas; Pinho, Marco C.; Ho, William W.; Ghosh, Mitrajit; Askoxylakis, Vasileios; Ferraro, Gino B.; Riedemann, Lars; Gerstner, Elizabeth; Batchelor, Tracy; Wen, Patrick; Lin, Nancy; Grodzinsky, Alan J.; Fukumura, Dai; Huang, Peigen; Baish, James W.; Padera, Timothy; Munn, Lance; Jain, Rakesh (Springer Science and Business Media LLC, 2019-01-07)
      The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on brain tissue ...

    • Vascular diseases await translation of blood vessels engineered from stem cells 

      Samuel, Rekha; Duda, Dan Gabriel; Fukumura, Dai; Jain, Rakesh K. (American Association for the Advancement of Science (AAAS), 2015)
      The discovery of human induced pluripotent stem cells (hiPSCs) opened new avenues for research and potential clinical applications for tissue regeneration and engineering. In particular,hiPSCs may offer a long sought ...