Browsing by Author "Ksander, Bruce"

Now showing items 1-8 of 8

    •  B-Crystallin Protects Retinal Tissue during Staphylococcus aureus- Induced Endophthalmitis 

      Whiston, E. A.; Sugi, N.; Kamradt, M. C.; Sack, C.; Heimer, S. R.; Engelbert, M.; Wawrousek, E. F.; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, M. S. (American Society for Microbiology, 2008)
      Bacterial infections of the eye highlight a dilemma that is central to all immune-privileged sites. On the one hand, immune privilege limits inflammation to prevent bystander destruction of normal tissue and loss of vision. ...

    • Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions 

      Zahr, Alisar; Alcaide, Pilar; Yang, Jinling; Jones, Alexander; Gregory, Meredith; dela Paz, Nathaniel G.; Patel-Hett, Sunita; Nevers, Tania; Koirala, Adarsha; Luscinskas, Francis W.; Saint-Geniez, Magali; Ksander, Bruce; D'Amore, Patricia A.; Argüeso, Pablo (Nature Publishing Group, 2016)
      Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on ...

    • Local Treatment With Alpha-Melanocyte Stimulating Hormone Reduces Corneal Allorejection 

      Hamrah, Pedram; Haskova, Zdenka; Taylor, Andrew W.; Zhang, Qiang; Ksander, Bruce R.; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background Corneal grafting is by far the most common form of transplantation. Many grafts suffer from immune rejection and current therapies are associated with many side effects, requiring more effective and safe ...

    • NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration 

      Tseng, Wenche; Thein, Thuzar; Kinnunen, Kati; Lashkari, Kameran; Gregory, Meredith S.; D'Amore, Patricia Ann; Ksander, Bruce R. (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose.: To evaluate the effect of lysosomal destabilization on NLRP3 inflammasome activation in RPE cells and to investigate the mechanisms by which inflammasome activation may contribute to the pathogenesis of age-related ...

    • Opposing Roles For Membrane Bound and Soluble Fas Ligand in Glaucoma-Associated Retinal Ganglion Cell Death 

      Hackett, Caroline G.; Abernathy, Emma F.; Hohlbaum, Andreas M.; Moody, Krishna-sulayman L.; Hobson, Maura W.; Jones, Alexander; Karray, Saoussen; Giani, Andrea; John, Simon W. M.; Marshak-Rothstein, Ann; Gregory, Meredith S.; Lee, Karen S.; Saff, Rebecca Rose; Kolovou, Paraskevi-Evi; Chen, Dong Feng; Ksander, Bruce R. (Public Library of Science, 2011)
      Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular ...

    • Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma 

      Buys, Emmanuel S.; Potter, Lincoln R.; Pasquale, Louis R.; Ksander, Bruce R. (Frontiers Media S.A., 2014)
      Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will ...

    • Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma 

      Ko, Yu-Chieh; Hayton, Sarah R.; Jones, Alexander; Tainsh, Laurel T.; Ren, Ruiyi; Giani, Andrea; Clerté, Maeva; Abernathy, Emma; de Waard, Nadine; Turcotte, Raphael; Nathan, Daniel; Loomis, Stephanie J.; Gong, Haiyan; Brouckaert, Peter; Buys, Emmanuel; Alt, Clemens; Tainsh, Robert Edward Tillinghast; Oh, Dong-Jin; Malhotra, Rajeev; Arora, Pankaj; Yu, Binglan; Scherrer-Crosbie, Marielle; Kang, Jae Hee Hee; Lin, Charles P.; Rhee, Douglas J; Wiggs, Janey Lee; Gregory, Meredith S.; Pasquale, Louis; Bloch, Kenneth Daniel; Ksander, Bruce R. (Public Library of Science, 2013)
      Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the \(α_1\) subunit of the nitric ...

    • Spontaneous Bacterial Keratitis in CD36 Knockout Mice 

      Klocke, Julia; Barcia, Rita N.; Heimer, Susan; Cario, Elke; Zieske, James D.; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, Meredith (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose: CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier. The aim ...