Now showing items 1-8 of 8

    • Activation of the Unfolded Protein Response Enhances Motor Recovery after Spinal Cord Injury 

      Valenzuela, V.; Collyer, E.; Armentano, D.; Parsons, G. B.; Court, F. A.; Hetz, Claudio (Nature Publishing Group, 2012)
      Spinal cord injury (SCI) is a major cause of paralysis, and involves multiple cellular and tissular responses including demyelination, inflammation, cell death and axonal degeneration. Recent evidence suggests that ...
    • Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury 

      Oñate, Maritza; Catenaccio, Alejandra; Martínez, Gabriela; Armentano, Donna; Parsons, Geoffrey; Kerr, Bredford; Hetz, Claudio; Court, Felipe A. (Nature Publishing Group, 2016)
      Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...
    • Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease 

      Torres, Mauricio; Cartier, Luis; Matamala, José Manuel; Hernández, Nancy; Woehlbier, Ute; Hetz, Claudio (Public Library of Science, 2012)
      Creutzfeldt-Jakob disease (CJD) is the most frequent human Prion-related disorder (PrD). The detection of 14-3-3 protein in the cerebrospinal fluid (CSF) is used as a molecular diagnostic criterion for patients clinically ...
    • Autophagy Impairment: A Crossroad between Neurodegeneration and Tauopathies 

      Nassif, Melissa; Hetz, Claudio (BioMed Central, 2012)
      Most neurodegenerative diseases involve the accumulation of misfolded proteins in the nervous system. Impairment of protein degradation pathways such as autophagy is emerging as a consistent and transversal pathological ...
    • A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway 

      Zamorano, Sebastián; Rojas-Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero, Sergio; Hetz, Claudio (Public Library of Science, 2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • ER Dysfunction and Protein Folding Stress in ALS 

      Matus, Soledad; Valenzuela, Vicente; Medinas, Danilo B.; Hetz, Claudio (Hindawi Publishing Corporation, 2013)
      Amyotrophic lateral sclerosis (ALS) is the most frequent paralytic disease in adults. Most ALS cases are considered sporadic with no clear genetic component. The disruption of protein homeostasis due to chronic stress ...
    • Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis 

      Matus, Soledad; Lopez, Estefanía; Valenzuela, Vicente; Nassif, Melissa; Hetz, Claudio (Public Library of Science, 2013)
      Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation ...
    • Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration 

      Castillo, Valentina; Oñate, Maritza; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz, Claudio (Public Library of Science, 2015)
      ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ...