Browsing by Author "Yarmush, Martin"
Now showing items 1-20 of 29
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Bioinformatics Analysis of the Early Inflammatory Response in a Rat Thermal Injury Model
Yang, Eric; Maguire, Timothy; Yarmush, Martin Leon; Berthiaume, Francois; Androulakis, Ioannis P (BioMed Central, 2007)Background: Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged ... -
Cloud-Enabled Microscopy and Droplet Microfluidic Platform for Specific Detection of Escherichia coli in Water
Golberg, Alexander; Linshiz, Gregory; Kravets, Ilia; Stawski, Nina; Hillson, Nathan J.; Yarmush, Martin L.; Marks, Robert S.; Konry, Tania (Public Library of Science, 2014)We report an all-in-one platform – ScanDrop – for the rapid and specific capture, detection, and identification of bacteria in drinking water. The ScanDrop platform integrates droplet microfluidics, a portable imaging ... -
Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats
Izamis, Maria-Louisa; Uygun, Korkut; Sharma, Nripen S.; Uygun, Basak; Yarmush, Martin L.; Berthiaume, Francois (MDPI, 2012)Hypermetabolism is a significant sequela to severe trauma such as burns, as well as critical illnesses such as cancer. It persists in parallel to, or beyond, the original pathology for many months as an often-fatal ... -
Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin
Shulman, Maria; Cohen, Merav; Soto-Gutierrez, Alejandro; Yagi, Hiroshi; Wang, Hongyun; Goldwasser, Jonathan; Lee-Parsons, Carolyn W.; Benny-Ratsaby, Ofra; Yarmush, Martin Leon; Nahmias, Yaakov (Public Library of Science, 2011)The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both in vitro and in vivo. Recently, our group ... -
Eradication of Multidrug-Resistant Pseudomonas Biofilm With Pulsed Electric Fields
Khan, Saiqa I.; Blumrosen, Gaddi; Vecchio, Daniela; Golberg, Alexander; Hamblin, Michael; McCormack, Michael; Yarmush, Martin; Austen, William (Wiley, 2015-09-09)Biofilm formation is a significant problem, accounting for over eighty percent of microbial infections in the body. Biofilm eradication is problematic due to increased resistance to antibiotics and antimicrobials as compared ... -
A Fitness Index for Transplantation of Machine-Perfused Cadaveric Rat Livers
Tolboom, Herman; Perk, Sinem; Izamis, Maria Louisa; Uygun, Basak E.; Yarmush, Martin Leon; Uygun, Mustafa (BioMed Central, 2012)Background: The 110,000 patients currently on the transplant waiting list reflect the critical shortage of viable donor organs. However, a large pool of unused organs, from donors after cardiac death (DCD) that are ... -
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
Luther, Jay; Garber, John J.; Khalili, Hamed; Dave, Maneesh; Bale, Shyam Sundhar; Jindal, Rohit; Motola, Daniel L.; Luther, Sanjana; Bohr, Stefan; Jeoung, Soung Won; Deshpande, Vikram; Singh, Gurminder; Turner, Jerrold R.; Yarmush, Martin L.; Chung, Raymond T.; Patel, Suraj J. (2015)BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ... -
Highly Upregulated Lhx2 in the Foxn1\(^{−/−}\) Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche
Bohr, Stefan; Patel, Suraj J; Vasko, Radovan; Shen, Keyue; Huang, Guofeng; Yarmush, Martin Leon; Berthiaume, Francois (Public Library of Science, 2013)Hair cycling is a prime example of stem cell dependent tissue regeneration and replenishment, and its regulatory mechanisms remain poorly understood. In the present study, we evaluated the effect of a blockage in terminal ... -
The Inflammatory Response to Double Stranded DNA in Endothelial Cells Is Mediated by by NF\(\kappa\)B and TNF\(\alpha\)
Patel, Suraj J; Jindal, Rohit; King, Kevin Robert; Tilles, Arno W.; Yarmush, Martin Leon (Public Library of Science, 2011)Endothelial cells represent an important barrier between the intravascular compartment and extravascular tissues, and therefore serve as key sensors, communicators, and amplifiers of danger signals in innate immunity and ... -
Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response
Bale, Shyam Sundhar; Geerts, Sharon; Jindal, Rohit; Yarmush, Martin L. (Nature Publishing Group, 2016)The liver is a central organ in the human body, and first line of defense between host and external environment. Liver response to any external perturbation is a collective reaction of resident liver cells. Most of the ... -
Live single cell functional phenotyping in droplet nano-liter reactors
Konry, Tania; Golberg, Alexander; Yarmush, Martin (Nature Publishing Group, 2013)While single cell heterogeneity is present in all biological systems, most studies cannot address it due to technical limitations. Here we describe a nano-liter droplet microfluidic-based approach for stimulation and ... -
Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure
Parekkadan, Biju; van Poll, Daan; Suganuma, Kazuhiro; Carter, Edward Albert; Tilles, Arno W.; Yarmush, Martin Leon (Public Library of Science, 2007)Modulation of the immune system may be a viable alternative in the treatment of fulminant hepatic failure (FHF) and can potentially eliminate the need for donor hepatocytes for cellular therapies. Multipotent bone ... -
Metabolic Profiling Based Quantitative Evaluation of Hepatocellular Metabolism in Presence of Adipocyte Derived Extracellular Matrix
Sharma, Nripen S.; Nagrath, Deepak; Yarmush, Martin Leon (Public Library of Science, 2011)The elucidation of the effect of extracellular matrices on hepatocellular metabolism is critical to understand the mechanism of functional upregulation. We have developed a system using natural extracellular matrices ... -
A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation
McCarty, William J.; Usta, O. Berk; Yarmush, Martin L. (Nature Publishing Group, 2016)In vitro liver models have been important tools for more than 40 years for academic research and preclinical toxicity screening by the pharmaceutical industry. Hepatocytes, the highly metabolic parenchymal cells of the ... -
Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats
Vitalo, Antonia; Fricchione, Jonathan; Hoge, Elizabeth A.; Casali, Monica; Berdichevsky, Yevgeny; Rauch, Scott Laurence; Berthiaume, Francois; Yarmush, Martin Leon; Benson, Herbert; Fricchione, Gregory Lewis; Levine, John Brenner (Public Library of Science, 2009)Background: Environmental enrichment (EE) fosters attachment behavior through its effect on brain oxytocin levels in the hippocampus and other brain regions, which in turn modulate the hypothalamic-pituitary axis (HPA). ... -
A Novel Resolvin-Based Strategy for Limiting Acetaminophen Hepatotoxicity
Patel, Suraj J; Luther, Jay; Bohr, Stefan; Iracheta-Vellve, Arvin; Li, Matthew; King, Kevin R; Chung, Raymond T; Yarmush, Martin L (Nature Publishing Group, 2016)Objectives: Acetaminophen (APAP)-induced hepatotoxicity is a major cause of morbidity and mortality. The current pharmacologic treatment for APAP hepatotoxicity, N-acetyl cysteine (NAC), targets the initial metabolite-driven ... -
Personalized Medicine Approaches in Prostate Cancer Employing Patient Derived 3D Organoids and Humanized Mice
Bartucci, Monica; Ferrari, Anna C.; Kim, Isaac Yi; Ploss, Alexander; Yarmush, Martin; Sabaawy, Hatem E. (Frontiers Media S.A., 2016)Prostate cancer (PCa) is the most common malignancy and the second most common cause of cancer death in Western men. Despite its prevalence, PCa has proven very difficult to propagate in vitro. PCa represents a complex ... -
Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells
Elman, Jessica S.; Murray, Ryan M.; Wang, Fangjing; Shen, Keyue; Gao, Shan; Conway, Kevin E.; Yarmush, Martin L.; Tannous, Bakhos A.; Weissleder, Ralph; Parekkadan, Biju (Public Library of Science, 2014)Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally ... -
Resolving Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays
Shen, Keyue; Luk, Samantha; Hicks, Daniel F; Elman, Jessica S; Bohr, Stefan; Iwamoto, Yoshiko; Murray, Ryan; Pena, Kristen; Wang, Fangjing; Seker, Erkin; Weissleder, Ralph; Yarmush, Martin L; Toner, Mehmet; Sgroi, Dennis; Parekkadan, Biju (2014)Tumor-stromal interactions are a determining factor in cancer progression. In vivo, the interaction interface is associated with spatially-resolved distributions of cancer and stromal phenotypes. Here, we establish a ... -
Resuscitation of Ischemic Donor Livers with Normothermic Machine Perfusion: A Metabolic Flux Analysis of Treatment in Rats
Izamis, Maria-Louisa; Tolboom, Herman; Uygun, Basak; Berthiaume, Francois; Yarmush, Martin L.; Uygun, Korkut (Public Library of Science, 2013)Normothermic machine perfusion has previously been demonstrated to restore damaged warm ischemic livers to transplantable condition in animal models. However, the mechanisms of recovery are unclear, preventing rational ...