Browsing by Author "Sadow, Peter"
Now showing items 1-7 of 7
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Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
Borre, Pierre Vanden; Gunda, Viswanath; McFadden, David G.; Sadow, Peter M.; Varmeh, Shohreh; Bernasconi, Maria; Parangi, Sareh (Impact Journals LLC, 2014)Anaplastic (ATC) and refractory papillary thyroid cancer (PTC) lack effective treatments. Inhibition of either oncogenic BRAF or SRC has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug ... -
Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model
Duquette, Mark; Sadow, Peter M.; Husain, Amjad; Sims, Jennifer N.; Antonello, Zeus A.; Fischer, Andrew H.; Song, Chen; Castellanos-Rizaldos, Elena; Makrigiorgos, G. Mike; Kurebayashi, Junichi; Nose, Vania; Van Hummelen, Paul; Bronson, Roderick T.; Vinco, Michelle; Giordano, Thomas J.; Dias-Santagata, Dora; Pandolfi, Pier Paolo; Nucera, Carmelo (Impact Journals LLC, 2015)BRAFV600E mutation exerts an essential oncogenic function in many tumors, including papillary thyroid carcinoma (PTC). Although BRAFV600E inhibitors are available, lack of response has been frequently observed. To study ... -
Metastatic Renal Cell Carcinoma to the Sinonasal Cavity: A Case Series
Remenschneider, Aaron K.; Sadow, Peter M.; Lin, Derrick T.; Gray, Stacey T. (Georg Thieme Verlag KG, 2013)Objectives: To describe the presentation, work-up, and management of patients with metastatic renal cell carcinoma (RCC) to the sinonasal cavity and skull base, and to describe our current treatment algorithm of endoscopic ... -
Poorly Differentiated Thyroid Carcinoma: An Incubating Entity
Sadow, Peter Mark; Faquin, William Clay (Frontiers Research Foundation, 2012) -
SCF\(^{β-TRCP}\) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2
Shaik, Shavali; Nucera, Carmelo; Inuzuka, Hiroyuki; Gao, Daming; Garnaas, Maija; Frechette, Gregory Martin; Harris, Lauren; Wan, Lixin; Fukushima, Hidefumi; Husain, Amjad; Nose, Vania; Fadda, Guido; Sadow, Peter Mark; Goessling, Wolfram; North, Trista Elizabeth; Lawler, Jack William; Wei, Wenyi (The Rockefeller University Press, 2012)The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype of this disease is resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes ... -
Skull base erosion and associated complications in sphenoid sinus fungal balls
Meier, Josh C.; Scangas, George A.; Remenschneider, Aaron K.; Sadow, Peter; Chambers, Kyle; Dedmon, Matt; Lin, Derrick T.; Holbrook, Eric H.; Metson, Ralph; Gray, Stacey T. (OceanSide Publications, Inc., 2016)Background: Sphenoid sinus fungal balls (SSFB) are rare entities that can result in serious orbital and intracranial complications. There are few published reports of complications that result from SSFB. Objective: To ... -
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAFV600E: New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment
Duquette, Mark; Sadow, Peter M.; Lawler, Jack; Nucera, Carmelo (Frontiers Media S.A., 2013)Background and Rationale: Anaplastic thyroid cancer (ATC) is characterized by pleomorphic cells, has a poor prognosis, is highly devastating disease, and is not curable. No reliable biomarkers of metastatic potential, ...