Now showing items 1-20 of 86

    • Adolescent diet and risk of breast cancer 

      Frazier, A. Lindsay; Ryan, Catherine Tomeo; Rockett, Helaine; Willett, Walter C.; Colditz, Graham A. (BioMed Central, 2003)
      Background: Early life exposures, including diet, have been implicated in the etiology of breast cancer. Methods: A nested case-control study was conducted among participants in the Nurses' Health Study who completed a ...
    • Adolescent Diet Quality and Cardiovascular Disease Risk Factors and Incident Cardiovascular Disease in Middle‐Aged Women 

      Dahm, Christina C.; Chomistek, Andrea K.; Jakobsen, Marianne Uhre; Mukamal, Kenneth J.; Eliassen, A. Heather; Sesso, Howard D.; Overvad, Kim; Willett, Walter C.; Rimm, Eric B.; Chiuve, Stephanie E. (John Wiley and Sons Inc., 2016)
      Background: Primary prevention of cardiovascular disease (CVD) focuses on treatment of risk factors, including hypercholesterolemia, hypertension, and type 2 diabetes mellitus. We investigated whether a healthy diet in ...
    • Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk 

      Liu, Ying; Colditz, Graham A.; Rosner, Bernard; Berkey, Catherine S.; Collins, Laura C.; Schnitt, Stuart J.; Connolly, James L.; Chen, Wendy Y.; Willett, Walter C.; Tamimi, Rulla M. (Oxford University Press, 2013)
      Background: Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has ...
    • Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study 

      Varraso, Raphaëlle; Chiuve, Stephanie E; Fung, Teresa T; Barr, R Graham; Hu, Frank B; Willett, Walter C; Camargo, Carlos A (BMJ Publishing Group Ltd., 2015)
      Objective: To investigate the association between the Alternate Healthy Eating Index 2010 (AHEI-2010)—a measure of diet quality—and the risk of chronic obstructive pulmonary disease (COPD). Design: Prospective cohort study. ...
    • Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma 

      Kang, Jae Hee; Willett, Walter C.; Rosner, Bernard Alfred; Buys, Emmanuel; Wiggs, Janey Lee; Pasquale, Louis (American Medical Association (AMA), 2016)
      IMPORTANCE Nitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. ...
    • Association of Nut Consumption with Total and Cause-Specific Mortality 

      Bao, Ying; Han, Jiali; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir; Willett, Walter C.; Fuchs, Charles Stewart (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND: Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and ...
    • Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome 

      Shurubor, Yevgeniya I; Matson, Wayne R; Willett, Walter C.; Hankinson, Susan Elizabeth; Kristal, Bruce S. (BioMed Central, 2007)
      Background: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations ...
    • Birth weight and later life adherence to unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study 

      Li, Yanping; Ley, Sylvia H; Tobias, Deirdre K; Chiuve, Stephanie E; VanderWeele, Tyler J; Rich-Edwards, Janet W; Curhan, Gary C; Willett, Walter C; Manson, JoAnn E; Hu, Frank B; Qi, Lu (BMJ Publishing Group Ltd., 2015)
      Objectives To prospectively assess the joint association of birth weight and established lifestyle risk factors in adulthood with incident type 2 diabetes and to quantitatively decompose the attributing effects to birth ...
    • Body Fatness During Childhood and Adolescence and Incidence of Breast Cancer in Premenopausal Women: A Prospective Cohort Study 

      Baer, Heather Joanne; Colditz, Graham A.; Rosner, Bernard Alfred; Michels, Karin B.; Rich-Edwards, Janet Wilson; Hunter, David J.; Willett, Walter C. (BioMed Central, 2005)
      Introduction: Body mass index (BMI) during adulthood is inversely related to the incidence of premenopausal breast cancer, but the role of body fatness earlier in life is less clear. We examined prospectively the relation ...
    • Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes 

      Tobias, Deirdre Kay; Pan, An; Jackson, Chandra L.; O'Reilly, Eilis J.; Ding, Eric L.; Willett, Walter C.; Manson, JoAnn E.; Hu, Frank B. (New England Journal of Medicine (NEJM/MMS), 2014)
      Background: The relation between body weight and mortality among persons with type 2 diabetes remains unresolved, with some studies suggesting decreased mortality among overweight or obese persons as compared with normal-weight ...
    • Breast Cancer in Developing Countries: Opportunities for Improved Survival 

      Shulman, Lawrence Nathan; Willett, Walter C.; Sievers, Amy Claire; Knaul, Felicia Marie (Hindawi Publishing Corporation, 2010)
      Breast cancer survival in the USA has continually improved over the last six decades and has largely been accredited to the use of mammography, advanced surgical procedures, and adjuvant therapies. Data indicate, however, ...
    • Challenges and opportunities in establishing a collaborative multisite observational study of chronic diseases and lifestyle factors among adults in Puerto Rico 

      Mattei, Josiemer; Rodríguez-Orengo, José F.; Tamez, Martha; Corujo, Francheska; Claudio, Aida; Villanueva, Héctor; Campos, Hannia; Willett, Walter C.; Tucker, Katherine L.; Ríos-Bedoya, Carlos F. (Springer Nature, 2017)
      Background Prevalence of chronic diseases and unhealthy lifestyle behaviors among the adult population of Puerto Rico (PR) is high; however, few epidemiological studies have been conducted to address these. We aimed to ...
    • Changes in water and beverage intake and long-term weight changes: results from three prospective cohort studies 

      Pan, An; Malik, Vasanti S.; Hao, Tao; Willett, Walter C.; Mozaffarian, Dariush; Hu, Frank B. (2013)
      Objective: To examine the long-term relationship between changes in water and beverage intake and weight change. Subjects Prospective cohort studies of 50 013 women aged 40-64 in the Nurses’ Health Study (NHS, 1986-2006), ...
    • The Combined Influence of Multiple Sex and Growth Hormones on Risk of Postmenopausal Breast Cancer: A Nested Case-control Study 

      Tworoger, Shelley Slate; Rosner, Bernard Alfred; Willett, Walter C.; Hankinson, Susan Elizabeth (BioMed Central, 2011)
      Introduction: Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously. Methods: We considered the roles ...
    • Common germline polymorphisms associated with breast cancer-specific survival 

      Pirie, Ailith; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Dunning, Alison M; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Dieter; Weltens, Caroline; Leunen, Karin; van Ongeval, Chantal; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A; Olsen, Janet E; Hallberg, Emily; Vachon, Celine; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A; Henderson, Brian E; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C; Cross, Simon S; Reed, Malcolm WR; Giles, Graham G; Milne, Roger L; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J; Hollestelle, Antoinette; Martens, John WM; van den Ouweland, Ans MW; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert AEM; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W; Hein, Alexander; Ekici, Arif B; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Siljie; Evans, D Gareth; Abraham, Jean; Earl, Helena; Poole, Christopher J; Hiller, Louise; Dunn, Janet A; Bowden, Sarah; Yang, Rose; Campa, Daniele; Diver, W Ryan; Gapstur, Susan M; Gaudet, Mia M; Hankinson, Susan; Hoover, Robert N; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J; Chenevix-Trench, Georgia; Mannermaa, Arto; Andrulis, Irene L; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F; Bojesen, Stig E; Cox, Angela; Fasching, Peter A; Pharoah, Paul DP; Schmidt, Marjanka K (BioMed Central, 2015)
      Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was ...
    • Consumption and acceptability of whole grain staples for lowering markers of diabetes risk among overweight and obese Tanzanian adults 

      Muhihi, Alfa; Gimbi, Dorothy; Njelekela, Marina; Shemaghembe, Emmanuel; Mwambene, Kissah; Chiwanga, Faraja; Malik, Vasanti S; Wedick, Nicole M; Spiegelman, Donna; Hu, Frank B; Willett, Walter C (BioMed Central, 2013)
      Background: Dietary changes characterized by a reduction in carbohydrate quality are occurring in developing countries and may be associated with a higher prevalence of obesity and chronic diseases such as type 2 diabetes ...
    • Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts 

      Ding, Ming; Pan, An; Manson, JoAnn E.; Willett, Walter C.; Malik, Vasanti; Rosner, Bernard; Giovannucci, Edward; Hu, Frank B.; Sun, Qi (2016)
      Background: Evidence regarding the consumption of soy foods and isoflavones in relation to risk of type 2 diabetes (T2D) is scarce. Objective: Our study was to evaluate the association between soy food and isoflavone ...
    • Creating Healthy Nutrition Environments 

      Khandpur, Neha (2016-05-03)
      The home nutrition environment and the consumer nutrition environment present two important settings for addressing the high prevalence of overweight and obesity among children and adults. They provide the broader context ...
    • Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis 

      Chen, Mu; Sun, Qi; Giovannucci, Edward; Mozaffarian, Dariush; Manson, JoAnn E; Willett, Walter C; Hu, Frank B (BioMed Central, 2014)
      Background: The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy ...
    • Diet, nutrition, and avoidable cancer 

      Willett, Walter C. (US Department of Health and Human Services, 1995)
      In a 1981 review, Doll and Peto estimated that approximately 35% of cancer deaths in the United States were potentially avoidable by the modification of diet but that this percentage might be as low as 10% or as high as ...