Now showing items 1-11 of 11

    • Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns 

      Bose, Suman; Singh, Rishi; Hanewich-Hollatz, Mikhail; Shen, Chong; Lee, Chia-Hua; Dorfman, David M.; Karp, Jeffrey M.; Karnik, Rohit (Nature Publishing Group, 2013)
      Flow fractionation of cells using physical fields to achieve lateral displacement finds wide applications, but its extension to surface molecule-specific separation requires labeling. Here we demonstrate affinity flow ...
    • A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue 

      Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.; Park, Kyeng Min; Cho, Woo Kyung; Villiger, Martin; Bouma, Brett E.; Pomahac, Bohdan; Karp, Jeffrey M. (2013)
      Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant ...
    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...
    • Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation 

      Alvarez, Mario M.; Aizenberg, Joanna; Analoui, Mostafa; Andrews, Anne M.; Bisker, Gili; Boyden, Edward S.; Kamm, Roger D.; Karp, Jeffrey Michael; Mooney, David J.; Oklu, Rahmi; Peer, Dan; Stolzoff, Michelle; Strano, Michael S.; Trujillo-de Santiago, Grissel; Webster, Thomas J.; Weiss, Paul; Khademhosseini, Ali (American Chemical Society (ACS), 2017)
      We discuss the state of the art and innovative micro- and nano- scale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the ...
    • Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids 

      Ankrum, James A.; Dastidar, Riddhi G.; Ong, Joon Faii; Levy, Oren; Karp, Jeffrey M. (Nature Publishing Group, 2014)
      Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary ...
    • A Portable Chemotaxis Platform for Short and Long Term Analysis 

      Xu, Chenjie; Poh, Yuk Kee C.; Roes, Isaac; O'Cearbhaill, Eoin D.; Matthiesen, Mads Emil; Mu, Luye; Yang, Seung Yun; Miranda-Nieves, David; Irimia, Daniel; Karp, Jeffrey Michael (Public Library of Science, 2012)
      Flow-based microfluidic systems have been widely utilized for cell migration studies given their ability to generate versatile and precisely defined chemical gradients and to permit direct visualization of migrating cells. ...
    • Quantification of Mesenchymal Stem Cell (MSC) Delivery to a Target Site Using In Vivo Confocal Microscopy 

      Mortensen, Luke J.; Levy, Oren; Phillips, Joseph P.; Stratton, Tara; Triana, Brian; Ruiz, Juan P.; Gu, Fangqi; Karp, Jeffrey M.; Lin, Charles P. (Public Library of Science, 2013)
      The ability to deliver cells to appropriate target tissues is a prerequisite for successful cell-based therapy. To optimize cell therapy it is therefore necessary to develop a robust method of in vivo cell delivery ...
    • Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study 

      Davies, Benjamin M; Rikabi, Sarah; French, Anna; Pinedo-Villanueva, Rafael; Morrey, Mark E; Wartolowska, Karolina; Judge, Andrew; MacLaren, Robert E; Mathur, Anthony; Williams, David J; Wall, Ivan; Birchall, Martin; Reeve, Brock; Atala, Anthony; Barker, Richard W; Cui, Zhanfeng; Furniss, Dominic; Bure, Kim; Snyder, Evan Y; Karp, Jeffrey M; Price, Andrew; Carr, Andrew; Brindley, David A (SAGE Publications, 2014)
      There has been a large increase in basic science activity in cell therapy and a growing portfolio of cell therapy trials. However, the number of industry products available for widespread clinical use does not match this ...
    • Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu 

      Vemula, Praveen Kumar; Kohler, Jonathan E.; Blass, Amy; Williams, Miguel; Xu, Chenjie; Chen, Lynna; Jadhav, Swapnil R.; John, George; Soybel, David I.; Karp, Jeffrey M. (Nature Publishing Group, 2014)
      Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence ...
    • Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns 

      Lee, Chia-Hua; Bose, Suman; Van Vliet, Krystyn J.; Karp, Jeffrey Michael; Karnik, Rohit (Journal of Visualized Experiments, 2011)
      Lateral displacement of cells orthogonal to a flow stream by rolling on asymmetric receptor patterns presents an opportunity for development of new devices for label-free separation and analysis of cells. Such devices may ...
    • Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation 

      Yang, Zijiang; Concannon, John; Ng, Kelvin S.; Seyb, Kathleen; Mortensen, Luke J.; Ranganath, Sudhir; Gu, Fangqi; Levy, Oren; Tong, Zhixiang; Martyn, Keir; Zhao, Weian; Lin, Charles P.; Glicksman, Marcie A.; Karp, Jeffrey M. (Nature Publishing Group, 2016)
      Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved ...