Now showing items 1-12 of 12

    • Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model 

      Tan, Chen; Broge, Thomas A.; Seung, Edward N.; Vrbanac, Vlad; Viscidi, Raphael; Gordon, Jennifer; Tager, Andrew Martin; Koralnik, Igor J. (Public Library of Science, 2013)
      Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model. ...
    • Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis 

      Montesi, Sydney B; Mathai, Susan K; Brenner, Laura N; Gorshkova, Irina A; Berdyshev, Evgeny V; Tager, Andrew M; Shea, Barry S (BioMed Central, 2014)
      Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and ...
    • Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9 

      Mandal, Pankaj Kumar; Ferreira, Leonardo Manuel Ramos; Collins, Ryan; Meissner, Torsten B; Boutwell, C; Friesen, Max; Vrbanac, Vladimir; Garrison, Brian Scott; Stortchevoi, Alexei; Bryder, David; Musunuru, Kiran; Brand, Harrison Andrew; Tager, Andrew Martin; Allen, Todd; Talkowski, Michael Edward; Rossi, Derrick J; Cowan, Chad A. (Elsevier BV, 2014)
      Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, ...
    • Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue 

      Ladinsky, Mark S.; Kieffer, Collin; Olson, Gregory; Deruaz, Maud; Vrbanac, Vladimir; Tager, Andrew M.; Kwon, Douglas S.; Bjorkman, Pamela J. (Public Library of Science, 2014)
      Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted early in infection. We used electron tomography (ET) to image HIV-1 ...
    • Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model 

      Greenblatt, Matthew Blake; Vbranac, Vladimir; Tivey, Trevor; Tsang, Kelly; Tager, Andrew Martin; Aliprantis, Antonios O. (Public Library of Science, 2012)
      Mice bearing a “humanized” immune system are valuable tools to experimentally manipulate human cells in vivo and facilitate disease models not normally possible in laboratory animals. Here we describe a form of GVHD that ...
    • HIV-infected T cells are migratory vehicles for viral dissemination 

      Murooka, Thomas; Deruaz, Maud; Marangoni, Francesco; Vrbanac, Vladimir D.; Seung, Edward N.; Von Andrian, Ulrich H.; Tager, Andrew Martin; Luster, Andrew David; Mempel, Thorsten Roman (2012)
      After host entry through mucosal surfaces, HIV-1 disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally ...
    • The Humanized BLT Mouse to Study HIV Transmission 

      Deruaz, Maud; Murooka, Thomas; Dudek, Timothy E; Vrbanac, VD; Tivet, T; Bankert, KC; Allen, Todd; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection 

      Adoro, Stanley; Cubillos-Ruiz, Juan R.; Chen, Xi; Deruaz, Maud; Vrbanac, Vladimir D.; Song, Minkyung; Park, Suna; Murooka, Thomas T.; Dudek, Timothy E.; Luster, Andrew D.; Tager, Andrew M.; Streeck, Hendrik; Bowman, Brittany; Walker, Bruce D.; Kwon, Douglas S.; Lazarevic, Vanja; Glimcher, Laurie H. (Nature Pub. Group, 2015)
      Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, ...
    • A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells 

      Stary, G; Olive, A; Radovic-Moreno, A. F.; Gondek, D.; Alvarez, David; Basto, P. A.; Perro, M.; Vrbanac, V. D.; Tager, Andrew Martin; Shi, Jinjun; Yethon, J. A.; Farokhzad, Omid Cameron; Langer, Robert S.; Starnbach, Michael N.; von Andrian, Ulrich H. (American Association for the Advancement of Science (AAAS), 2015)
      Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory ...
    • Neutralizing Anti-HIV Antibodies Develop in a Humanized Mouse Model of HIV-1 Infection 

      Vrbanac, V; Tivey, T; Cariappa, A; Seung, Edward N.; Dugast, Anne-Sophie; Dudek, Timothy E; Mattoo, Hamid Rasheed; Murooka, Thomas; Pillai, Shiv Subramaniam; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads 

      Seung, Edward; Dudek, Timothy E.; Allen, Todd M.; Freeman, Gordon J.; Luster, Andrew D.; Tager, Andrew M. (Public Library of Science, 2013)
      An estimated 34 million people are living with HIV worldwide (UNAIDS, 2012), with the number of infected persons rising every year. Increases in HIV prevalence have resulted not only from new infections, but also from ...
    • TLR7/9 Antagonist Reduces HIV-1-Induced Immune Activation 

      Chang, Ju-Hui; Lindsay, RJ; Doyle, EH; Vrbanac, V; Seung, Edward N.; Dudek, Timothy E; Bosch, Ronald J.; Precopio, M; Kandimalla, E; Tager, Andrew Martin; Altfeld, Marcus (BioMed Central, 2012)