Browsing by Author "Clemons, Paul"

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    • Plasticity of Ether Lipids Promotes Ferroptosis Susceptibility and Evasion 

      Zou, Yilong; Henry, Whitney S.; Ricq, Emily; Graham, Emily; Phadnis, Vaishnavi; Maretich, Pema; Paradkar, Sateja; Boehnke, Natalie; Deik, Amy; Reinhardt, Ferenc; Eaton, John K.; Ferguson, Bryan; Wang, Wenyu; Fairman, Joshua; Keys, Heather R.; Dančík, Vlado; Clish, Clary B.; Clemons, Paul; Hammond, Paula; Boyer, Laurie A.; Weinberg, Robert; Schreiber, Stuart L. (Springer Science and Business Media LLC, 2020-09-16)
      Ferroptosis, an iron-dependent, non-apoptotic cell death program, is involved in various degenerative diseases and represents a targetable vulnerability in certain cancers1. The ferroptosis-susceptible cell state can either ...

    • Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles 

      Eaton, John K.; Furst, Laura; Ruberto, Richard; Moosmayer, Dieter; Hilpmann, André; Ryan, Matthew J.; Zimmermann, Katja; Cai, Luke L.; Niehues, Michael; Badock, Volker; Kramm, Anneke; Chen, Sixun; Hillig, Roman C.; Clemons, Paul; Gradl, Stefan; Montagnon, Claire; Lazarski, Kiel E.; Christian, Sven; Bajrami, Besnik; Neuhaus, Roland; Eheim, Ashley L.; Viswanathan, Vasanthi S; Schreiber, Stuart L (Springer Science and Business Media LLC, 2020-03-30)
      We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple types of treatment results in a stable ...