Browsing by Author "Himes, Blanca"

Now showing items 1-15 of 15

    • Asthma-susceptibility variants identified using probands in case-control and family-based analyses 

      Murphy, Amy J; Soto-Quiros, Manuel E; Avila, Lydiana; Celedón, Juan C; O'Connor, George T; Himes, Blanca Elena; Su, Jessica Ann Lasky; Wu, Ann Chen; Wilk, Jemma B; Hunninghake, Gary Matthew; Klanderman, Barbara Jordan; Lazarus, Ross; Lange, Christoph; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman (BioMed Central, 2010)
      Background: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ...

    • Comprehensive Genetic Assessment of a Functional TLR9 Promoter Polymorphism: No Replicable Association with Asthma or Asthma-Related Phenotypes 

      Avila, Lydiana; Hawrylowicz, Catherine M; Lange, Nancy Elizabeth; Zhou, Xiaobo; Su, Jessica Ann Lasky; Himes, Blanca Elena; Lazarus, Ross; Raby, Benjamin Alexander; Litonjua, Augusto Ampil; Soto-Quiros, Manuel; Celedon, Juan C (BioMed Central, 2011)
      Background: Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional ...

    • Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans 

      Myers, Rachel A.; Himes, Blanca; Gignoux, Christopher R.; Yang, James J.; Gauderman, W. James; Rebordosa, Cristina; Xie, Jianming; Torgerson, Dara G.; Levin, Albert M.; Baurley, James; Graves, Penelope E.; Mathias, Rasika A.; Romieu, Isabelle; Roth, Lindsey A.; Conti, David; Avila, Lydiana; Eng, Celeste; Vora, Hita; LeNoir, Michael A.; Soto-Quiros, Manuel; Liu, Jinghua; Celedón, Juan C.; Farber, Harold J.; Kumar, Rajesh; Avila, Pedro C.; Meade, Kelley; Serebrisky, Denise; Thyne, Shannon; Rodriguez-Cintron, William; Rodriguez-Santana, Jose R.; Borrell, Luisa N.; Lemanske, Robert F.; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Barnes, Kathleen C.; Raby, Benjamin Alexander; Martinez, Fernando D.; Gilliland, Frank D.; Williams, L. Keoki; Burchard, Esteban G.; Weiss, Scott Tillman; Nicolae, Dan L.; Ober, Carole (Elsevier BV, 2012)
      Background: Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic ...

    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...

    • Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population 

      Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Doi, Satoru; Fujita, Kimie; Miyatake, Akihiko; Enomoto, Tadao; Miyagawa, Takehiko; Adachi, Mitsuru; Tanaka, Hiroshi; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Masuko, Hironori; Sakamoto, Tohru; Hizawa, Nobuyuki; Taniguchi, Masami; Lima, John J; Irvin, Charles G; Peters, Stephen P; Himes, Blanca; Litonjua, Augusto Ampil; Tantisira, Kelan; Weiss, Scott Tillman; Kamatani, Naoyuki; Nakamura, Yusuke; Tamari, Mayumi (Nature Publishing Group, 2011)

    • A genome-wide association study of bronchodilator response in asthmatics 

      Duan, Q; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Qiu, Weiliang; Litonjua, Augusto Ampil; Damask, Amy; Lazarus, Richard James; Klanderman, Barbara; Irvin, Charles G.; Peters, Stephen P; Hanrahan, John P; Lima, John J.; Martinez, Fernando D.; Mauger, David; Chinchilli, Vernon M.; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Lange, Christoph; Weiss, Scott Tillman; Tantisira, Kelan (Nature Publishing Group, 2013)
      Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) ...

    • A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study 

      Granada, Mark; Wilk, Jemma; Tuzova, Marina; Strachan, David P.; Weidinger, Stephan; Albrecht, Eva; Gieger, Christian; Heinrich, Joachim; Himes, Blanca; Hunninghake, Gary Matthew; Celedón, Juan C.; Weiss, Scott Tillman; Cruikshank, William W.; Farrer, Lindsay A.; Center, David M.; O'Connor, George T. (Elsevier BV, 2012)
      Background— Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. Objective— To ...

    • Genome-wide association study of the age of onset of childhood asthma 

      Forno, Erick; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Howrylak, Judie; Ramsey, Clare; Brehm, John; Klanderman, Barbara; Ziniti, John; Melén, Erik; Pershagen, Goran; Wickman, Magnus; Martinez, Fernando; Mauger, Dave; Sorkness, Christine; Tantisira, Kelan; Raby, Benjamin Alexander; Weiss, Scott Tillman; Celedón, Juan C. (Elsevier BV, 2012)
      BACKGROUND: Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study ...

    • A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes 

      Sharma, Sunita; Zhou, Xiaobo; Thibault, Derek M.; Himes, Blanca; Liu, Andy; Szefler, Stanley J.; Strunk, Robert; Castro, Mario; Hansel, Nadia N.; Diette, Gregory B.; Vonakis, Becky M.; Adkinson, N. Franklin; Avila, Lydiana; Soto-Quiros, Manuel; Barraza-Villareal, Albino; Lemanske, Robert F.; Solway, Julian; Krishnan, Jerry; White, Steven James; Cheadle, Chris; Berger, Alan E.; Fan, Jinshui; Boorgula, Meher Preethi; Nicolae, Dan; Gilliland, Frank; Barnes, Kathleen; London, Stephanie J.; Martinez, Fernando; Ober, Carole; Celedón, Juan C.; Carey, Vincent James; Weiss, Scott Tillman; Raby, Benjamin Alexander (Elsevier BV, 2014)
      Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ...

    • Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma 

      Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Harada, Michishige; Murphy, Amy; Litonjua, Augusto Ampil; Himes, Blanca; Lange, Christoph; Lazarus, Ross; Sylvia, Jody; Klanderman, Barbara; Duan, Qing Ling; Qiu, Weiliang; Hirota, Tomomitsu; Martinez, Fernando D.; Mauger, David; Sorkness, Christine; Szefler, Stanley; Lazarus, Stephen C.; Lemanske, Robert F.; Peters, Stephen P.; Lima, John J.; Nakamura, Yusuke; Tamari, Mayumi; Weiss, Scott Tillman (New England Journal of Medicine (NEJM/MMS), 2011)
      Background: The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would ...

    • Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics 

      Wu, Ann Chen; Himes, Blanca; Lasky-Su, Jessica A. Lasky; Litonjua, Augusto Ampil; Peters, Stephen P.; Lima, John; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Qiu, Weiliang; Weiss, Scott Tillman; Tantisira, Kelan (Elsevier BV, 2014)
      Background: Single nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of ...

    • Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis 

      Bunyavanich, Supinda; Schadt, Eric E; Himes, Blanca E; Lasky-Su, Jessica; Qiu, Weiliang; Lazarus, Ross; Ziniti, John P; Cohain, Ariella; Linderman, Michael; Torgerson, Dara G; Eng, Celeste S; Pino-Yanes, Maria; Padhukasahasram, Badri; Yang, James J; Mathias, Rasika A; Beaty, Terri H; Li, Xingnan; Graves, Penelope; Romieu, Isabelle; Navarro, Blanca del Rio; Salam, M Towhid; Vora, Hita; Nicolae, Dan L; Ober, Carole; Martinez, Fernando D; Bleecker, Eugene R; Meyers, Deborah A; Gauderman, W James; Gilliland, Frank; Burchard, Esteban G; Barnes, Kathleen C; Williams, L Keoki; London, Stephanie J; Zhang, Bin; Raby, Benjamin A; Weiss, Scott T (BioMed Central, 2014)
      Background: Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis. Methods: We performed genome wide association studies (GWAS) ...

    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...

    • A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations 

      Levin, Albert M.; Mathias, Rasika A.; Huang, Liling; Roth, Lindsey A.; Daley, Denise; Myers, Rachel A.; Himes, Blanca; Romieu, Isabelle; Yang, Mao; Eng, Celeste; Park, Julie E.; Zoratti, Karla; Gignoux, Christopher R.; Torgerson, Dara G.; Galanter, Joshua M.; Huntsman, Scott; Nguyen, Elizabeth A.; Becker, Allan B.; Chan-Yeung, Moira; Kozyrskyj, Anita L.; Kwok, Pui-Yan; Gilliland, Frank D.; Gauderman, W. James; Bleecker, Eugene R.; Raby, Benjamin Alexander; Meyers, Deborah A.; London, Stephanie J.; Martinez, Fernando D.; Weiss, Scott Tillman; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Barnes, Kathleen C.; Williams, L. Keoki (Elsevier BV, 2013)
      Background: Immunoglobulin E (IgE) is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino individuals have not been ...

    • RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells 

      Himes, Blanca E.; Jiang, Xiaofeng; Wagner, Peter; Hu, Ruoxi; Wang, Qiyu; Klanderman, Barbara; Whitaker, Reid M.; Duan, Qingling; Lasky-Su, Jessica; Nikolos, Christina; Jester, William; Johnson, Martin; Panettieri, Reynold A.; Tantisira, Kelan G.; Weiss, Scott T.; Lu, Quan (Public Library of Science, 2014)
      Asthma is a chronic inflammatory respiratory disease that affects over 300 million people worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti-inflammatory effects in multiple lung tissues, ...