Browsing by Author "Kocher, Olivier"
Now showing items 1-9 of 9
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Challenges in Using Cultured Primary Rodent Hepatocytes or Cell Lines to Study Hepatic HDL Receptor SR-BI Regulation by Its Cytoplasmic Adaptor PDZK1
Tsukamoto, Kosuke; Buck, Lorenna; Inman, Walker; Griffith, Linda; Kocher, Olivier; Krieger, Monty (Public Library of Science, 2013)Background: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins. ... -
Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure
Cheng, Jilin; Ke, Qingen; Jin, Zhuang; Wang, Haibin; Kocher, Olivier Nicolas; Morgan, James P.; Zhang, Jielin; Crumpacker, Clyde S. (Public Library of Science, 2009)Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several ... -
Loss of PDZK1 Causes Coronary Artery Occlusion and Myocardial Infarction in Paigen Diet-Fed Apolipoprotein E Deficient Mice
Yesilaltay, Ayce; Daniels, Kathleen; Pal, Rinku; Krieger, Monty; Kocher, Olivier Nicolas (Public Library of Science, 2009)Background: PDZK1 is a four PDZ-domain containing protein that binds to the carboxy terminus of the HDL receptor, scavenger receptor class B type I (SR-BI), and regulates its expression, localization and function in a ... -
Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1
Birrane, Gabriel; Mulvaney, Eamon P.; Pal, Rinku; Kinsella, B. Therese; Kocher, Olivier Nicolas (Public Library of Science, 2013)The prostanoid prostacyclin, or prostaglandin I2, plays an essential role in many aspects of cardiovascular disease. The actions of prostacyclin are mainly mediated through its activation of the prostacyclin receptor or, ... -
Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea
Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ... -
O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice
Shrikhande, Gautam V.; Scali, Salvatore T.; Csizmadia, Eva; Matthey, Michaela; Arjoon, Roy; Patel, Rakesh; Maccariello, Elizabeth R.; Andersen, Nicholas D.; Monahan, Thomas; Studer, Peter; Padilha Guedes, Renata; Usheva, Anny; Da Silva, Cleide Gonsalves; Damrauer, Scott Michael; Putheti, Prabhakar; Siracuse, Jeffrey Joseph; Peterson, Clayton Ross; Essayagh, Sanah; Kocher, Olivier Nicolas; Veves, Aristidis; Kaczmarek, Elzbieta; Ferran, Christiane (Public Library of Science, 2010)Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ... -
Smoking status and self-reported race affect the frequency of clinically relevant oncogenic alterations in non-small-cell lung cancers at a United States-based academic medical practice
Yamaguchi, Norihiro; Vanderlaan, Paul A; Folch, Erik E; Boucher, David H.; Canepa, Hannah M.; Kent, Michael; Gangadharan, Sidhu; Majid, Adnan; Kocher, Olivier Nicolas; Goldstein, Michael A.; Huberman, Mark S.; Costa, Daniel Botelho (Elsevier BV, 2013)Introduction The identification of somatic genomic aberrations in non-small-cell lung cancer (NSCLC) is part of evidence-based practice guidelines for care of patients with NSCLC. We sought to establish the frequency and ... -
Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer
Vanderlaan, Paul A; Yamaguchi, Norihiro; Folch, Erik E; Boucher, David H.; Kent, Michael; Gangadharan, Sidhu; Majid, Adnan; Goldstein, Michael A.; Huberman, Mark S.; Kocher, Olivier Nicolas; Costa, Daniel Botelho (Elsevier BV, 2014)Introduction—Identification of some somatic molecular alterations in non-small-cell lung cancer (NSCLC) has become evidence-based practice. The success and failure rate of using commercially-available tumor genotyping ... -
Temporal Network Based Analysis of Cell Specific Vein Graft Transcriptome Defines Key Pathways and Hub Genes in Implantation Injury
Bhasin, Manoj; Pradhan-Nabzdyk, Leena; LoGerfo, Philip J.; Guthrie, Patrick; Csizmadia, Eva; Andersen, Nicholas; Huang, Zhen S.; Malek, Junaid Yusuf; Contreras, Mauricio Antonio; Kocher, Olivier Nicolas; Ferran, Christiane; Logerfo, Frank W. (Public Library of Science, 2012)Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft ...