Browsing by Author "Orent, Will"

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    • Notch Signaling and T-Helper Cells in EAE/MS 

      Bassil, Ribal; Orent, William; Elyaman, Wassim (Hindawi Publishing Corporation, 2013)
      The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch ...

    • Tiam1/Rac1 complex controls Il17a transcription and autoimmunity 

      Kurdi, Ahmed T.; Bassil, Ribal; Olah, Marta; Wu, Chuan; Xiao, Sheng; Taga, Mariko; Frangieh, Michael; Buttrick, Thomas; Orent, William; Bradshaw, Elizabeth M.; Khoury, Samia J.; Elyaman, Wassim (Nature Publishing Group, 2016)
      RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family ...