Browsing by Author "Godec, Jernej"

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    • Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans 

      Ruparelia, Neil; Godec, Jernej; Lee, Regent; Chai, Joshua T.; Dall'Armellina, Erica; McAndrew, Debra; Digby, Janet E.; Forfar, J. Colin; Prendergast, Bernard D.; Kharbanda, Rajesh K.; Banning, Adrian P.; Neubauer, Stefan; Lygate, Craig A.; Channon, Keith M.; Haining, Nicholas W.; Choudhury, Robin P. (Oxford University Press, 2015)
      Aims Monocytes play critical roles in tissue injury and repair following acute myocardial infarction (AMI). Specifically targeting inflammatory monocytes in experimental models leads to reduced infarct size and improved ...

    • CD39 Expression Identifies Terminally Exhausted CD8+ T Cells 

      Gupta, Prakash K.; Godec, Jernej; Wolski, David; Adland, Emily; Yates, Kathleen; Pauken, Kristen E.; Cosgrove, Cormac; Ledderose, Carola; Junger, Wolfgang G.; Robson, Simon C.; Wherry, E. John; Alter, Galit; Goulder, Philip J. R.; Klenerman, Paul; Sharpe, Arlene H.; Lauer, Georg M.; Haining, W. Nicholas (Public Library of Science, 2015)
      Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially ...

    • Molecular Mechanisms of CD8+ T Cell Differentiation 

      Godec, Jernej (2016-04-25)
      CD8+ T cells are a crucial component of the adaptive immune system and are required for optimal protection from most pathogens and cancer. They function by secreting pro-inflammatory cytokines and by directly eliminating ...

    • The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells 

      Kurachi, Makoto; Barnitz, R. Anthony; Yosef, Nir; Odorizzi, Pamela M.; Dilorio, Michael A.; Lemieux, Madeleine E.; Yates, Kathleen; Godec, Jernej; Klatt, Martin G.; Regev, Aviv; Wherry, E. John; Haining, W. Nicholas (2014)
      The transcription factor BATF is required for interleukin 17 (IL-17)-producing helper T cell (TH17) and follicular helper T cell (TFH) differentiation. Here, we show that BATF also has a fundamental role in regulating ...