Now showing items 1-12 of 12

    • A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2 

      Breitkopf, Susanne B.; Yang, Xuemei; Begley, Michael J.; Kulkarni, Meghana; Chiu, Yu-Hsin; Turke, Alexa B.; Lauriol, Jessica; Yuan, Min; Qi, Jie; Engelman, Jeffrey A.; Hong, Pengyu; Kontaridis, Maria I.; Cantley, Lewis C.; Perrimon, Norbert; Asara, John M. (Nature Publishing Group, 2016)
      Using a series of immunoprecipitation (IP) – tandem mass spectrometry (LC-MS/MS) experiments and reciprocal BLAST, we conducted a fly-human cross-species comparison of the phosphoinositide-3-kinase (PI3K) interactome in a ...
    • Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines 

      Lauriol, Jessica; Cabrera, Janel Rodriguez; Roy, Ashbeel; Keith, Kimberly; Hough, Sara M.; Damilano, Federico; Wang, Bonnie; Segarra, Gabriel C.; Flessa, Meaghan E.; Miller, Lauren E.; Das, Saumya; Bronson, Roderick Terry; Lee, Kyu-Ho; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Hypertrophic cardiomyopathy is a common cause of mortality in congenital heart disease (CHD). Many gene abnormalities are associated with cardiac hypertrophy, but their function in cardiac development is not well understood. ...
    • Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus 

      Wang, Jianxun; Mizui, Masayuki; Zeng, Li-Fan; Bronson, Roderick Terry; Finnell, Michele; Terhorst, Cox; Kyttaris, Vasileios; Tsokos, George C.; Zhang, Zhong-Yin; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder ...
    • PTPN11-Associated Mutations in the Heart: Has LEOPARD Changed Its RASpots? 

      Lauriol, Jessica; Kontaridis, Maria Irene (Elsevier BV, 2011)
      In this review, we focus on elucidating the cardiac function of germline mutations in the PTPN11 gene, encoding the Src homology-2 (SH2) domain-containing protein tyrosine phosphatase SHP2. PTPN11 mutations cause LEOPARD ...
    • PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice 

      Paardekooper Overman, J.; Yi, J.-S.; Bonetti, M.; Soulsby, M.; Preisinger, C.; Stokes, Marquita Lavelle; Hui, L.; Silva, J. C.; Overvoorde, J.; Giansanti, P.; Heck, A. J. R.; Kontaridis, Maria Irene; den Hertog, J.; Bennett, A. M. (American Society for Microbiology, 2014)
      Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which manifests in congenital heart disease, short stature, and facial dysmorphia. The complexity of ...
    • Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation 

      Marin, Talita M.; Keith, Kimberly; Davies, Benjamin Ivor; Conner, David Atwater; Guha, Prajna; Kalaitzidis, Demetrios; Wu, Xue; Lauriol, Jessica; Wang, Bo; Bauer, Michael; Bronson, Roderick Terry; Franchini, Kleber G.; Neel, Benjamin G.; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2011)
      LEOPARD syndrome (LS) is an autosomal dominant “RASopathy” that manifests with congenital heart disease. Nearly all cases of LS are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), ...
    • Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: Palliative treatment with a rapamycin analog 

      Hahn, Andreas; Lauriol, Jessica; Thul, Josef; Behnke-Hall, Kachina; Logeswaran, Tushiha; Schänzer, Anne; Bögürcü, Nuray; Garvalov, Boyan K.; Zenker, Martin; Gelb, Bruce D.; von Gerlach, Susanne; Kandolf, Reinhard; Kontaridis, Maria Irene; Schranz, Dietmar (Wiley-Blackwell, 2015)
      Noonan syndrome with multiple lentigines (NSML) frequently manifests with hypertrophic cardiomyopathy (HCM). Recently, it was demonstrated that mTOR inhibition reverses HCM in NSML mice. We report for the first time on the ...
    • RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis 

      Lauriol, J; Keith, K.; Jaffre, Fabrice; Couvillon, A.; Saci, A.; Goonasekera, S. A.; McCarthy, Jason; Kessinger, Chase; Wang, J; Ke, Q; Kang, Peter Myung-Hoon; Molkentin, J. D.; Carpenter, C.; Kontaridis, Maria Irene (American Association for the Advancement of Science (AAAS), 2014)
      The Ras-related guanosine triphosphatase RhoA mediates pathological cardiac hypertrophy, but also promotes cell survival and is cardioprotective after ischemia/reperfusion injury. To understand how RhoA mediates these ...
    • Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts 

      Kontaridis, Maria Irene; Liu, X.; Zhang, L.; Bennett, A. M. (American Society for Microbiology, 2002)
      Ligand activation of the fibroblast growth factor receptor (FGFR) represses myogenesis and promotes activation of extracellular signal-regulated kinases 1 and 2 (Erks). The precise mechanism through which the FGFR transmits ...
    • SHP-2 complex formation with the SHP-2 substrate-1 during C2C12 myogenesis 

      Kontaridis, Maria Irene; Liu, Xiangdong; Zhang, Lang; Bennett, Anton (Company of Biologists, 2001)
      Myogenesis is a highly ordered process that involves the expression of muscle-specific genes, cell-cell recognition and multinucleated myotube formation. Although protein tyrosine kinases have figured prominently in ...
    • SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway 

      Kontaridis, Maria Irene; Eminaga, S.; Fornaro, M.; Zito, C. I.; Sordella, R.; Settleman, J; Bennett, A. M. (American Society for Microbiology, 2004)
      Myogenesis is an intricate process that coordinately engages multiple intracellular signaling cascades. The Rho family GTPase RhoA is known to promote myogenesis, however, the mechanisms controlling its regulation in ...
    • The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach 

      Korf, Bruce; Ahmadian, Reza; Allanson, Judith; Aoki, Yoko; Bakker, Annette; Wright, Emma Burkitt; Denger, Brian; Elgersma, Ype; Gelb, Bruce D.; Gripp, Karen W.; Kerr, Bronwyn; Kontaridis, Maria Irene; Lazaro, Conxi; Linardic, Corinne; Lozano, Reymundo; MacRae, Calum Archibald; Messiaen, Ludwine; Mulero-Navarro, Sonia; Neel, Benjamin; Plotkin, Scott Randall; Rauen, Katherine A.; Roberts, Amy Elizabeth; Silva, Alcino J.; Sittampalam, Sitta G.; Zhang, Chao; Schoyer, Lisa (Wiley-Blackwell, 2015)
      "The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway: Towards a Therapeutic Approach" was held at the Renaissance Orlando at SeaWorld Hotel (August 2-4, 2013). Seventy-one physicians and scientists ...