Now showing items 1-3 of 3

    • Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway 

      Chan, PuiYee; Han, Xiao; Zheng, Baohui; DeRan, Michael; Yu, Jianzhong; Jarugumilli, Gopala K.; Deng, Hua; Pan, Duojia; Luo, Xuelian; Wu, Xu (2016)
      TEA domain (TEAD) transcription factors bind to the co-activator YAP/TAZ, and regulate the transcriptional output of Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation ...
    • Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation 

      Bollu, Lakshmi Reddy; Katreddy, Rajashekhara Reddy; Blessing, Alicia Marie; Pham, Nguyen; Zheng, Baohui; Wu, Xu; Weihua, Zhang (Impact Journals LLC, 2015)
      Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR ...
    • ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity 

      Chen, Baoen; Zheng, Baohui; DeRan, Micael; Jarugumilli, Gopala K.; Fu, Jianjun; Brooks, Yang S.; Wu, Xu (2016)
      Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize ...