Now showing items 1-4 of 4

    • Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice 

      Minamishima, Shizuka; Kida, Kotaro; Tokuda, Kentaro; Wang, Huifang; Sips, Patrick; Kosugi, Shizuko; Mandeville, Joseph B.; Buys, Emmanuel; Brouckaert, Peter; Liu, Philip K.; Liu, Christina; Bloch, Kenneth Daniel; Ichinose, Fumito (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background—Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in patients. The objective of this study was to learn whether ...
    • Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI 

      Sander, C. Y.; Hooker, Jacob M; Catana, Ciprian; Normandin, Marc D; Alpert, Nathaniel Moritz; Knudsen, G. M.; Vanduffel, Wim J.M.; Rosen, Bruce; Mandeville, Joseph B. (Proceedings of the National Academy of Sciences, 2013)
      This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET ...
    • A Receptor-Based Model for Dopamine-Induced fMRI Signal 

      Mandeville, Joseph B.; Sander, Christin Y.M.; Jenkins, Bruce Gorton; Hooker, Jacob M; Catana, Ciprian; Vanduffel, Wim J.M.; Alpert, Nathaniel Moritz; Rosen, Bruce; Normandin, Marc D (Elsevier BV, 2013)
      This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in basal ganglia. The model is formulated as a summation of ...
    • Synthesis and Evaluation of Methylated Arylazepine Compounds for PET Imaging of 5-HT 2c Receptors 

      Granda, Michael L.; Carlin, Stephen M.; Moseley, Christian K.; Neelamegam, Ramesh; Mandeville, Joseph B.; Hooker, Jacob M (American Chemical Society (ACS), 2013)
      The serotonin 5-HT2c receptor is implicated in a number of diseases including obesity, depression, anxiety, and schizophrenia. In order to ascribe the role of 5-HT2c in these diseases, a method for measuring 5-HT2c density ...