Now showing items 1-9 of 9

    • Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus 

      Leinonen, Ville; Menon, Lata G.; Carroll, Rona Stephanie; Dello Iacono, Donna; Grevet, Jeremy; Jääskeläinen, Juha E.; Black, Peter McLaren (SAGE-Hindawi Access to Research, 2011)
      The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging. Alzheimer's disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential ...
    • Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. 

      Maxwell, M; Naber, S P; Wolfe, H J; Galanopoulos, T; Hedley-Whyte, E. Tessa; Black, Peter McLaren; Antoniades, H N (American Society for Clinical Investigation, 1990)
      The present studies investigated the expression of the two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human astrocytomas. Northern blot analysis demonstrated the coexpression ...
    • High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors 

      RIGHI, VALERIA; ANDRONESI, OVIDIU C.; MINTZOPOULOS, DIONYSSIOS; BLACK, PETER M.; TZIKA, A. ARIA (D.A. Spandidos, 2010)
      The non-essential amino acid neurotransmitter glycine (Gly) may serve as a biomarker for brain tumors. Using 36 biopsies from patients with brain tumors [12 glioblastoma multiforme (GBM); 10 low-grade (LG), including 7 ...
    • Monitoring and visualization techniques for MR-guided laser ablations in an open MR system 

      Kettenbach, Joachim; Silverman, Stuart George; Hata, Nobuhiko; Kuroda, Kagayaki; Saiviroonporn, Pairash; Zientara, Gary Peter; Morrison, Paul T; Hushek, Stephen G.; Black, Peter McLaren; Kikinis, Ron; Jolesz, Ferenc A. (Wiley-Blackwell, 1998)
      Our purpose was to develop temperature sensitive MR sequences and image-processing techniques to asses their potential of monitoring interstitial laser therapy (ILT) in brain tumors (n = 3) and liver tumors (n = 7). ILT ...
    • Morphological Characteristics of Brain Tumors Causing Seizures 

      Lee, Jong Woo; Wen, Patrick Yung Chih; Hurwitz, Shelley; Black, Peter McLaren; Kesari, Santosh; Drappatz, Jan; Golby, Alexandra Jacqueline; Wells, William Mercer; Warfield, Simon Keith; Kikinis, Ron; Bromfield, Edward B. (American Medical Association (AMA), 2010)
      Objective: To quantify size and localization differences between tumors presenting with seizures vs nonseizure neurological symptoms. Design: Retrospective imaging survey. We performed magnetic resonance imaging–based ...
    • Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16Ink4a Mutations 

      Kalamarides, Michel; Stemmer-Rachamimov, Anat; Takahashi, Masaya; Han, Zhi-Yan; Chareyre, Fabrice; Niwa-Kawakita, Michiko; Black, Peter McLaren; Carroll, Rona Stephanie; Giovannini, Marco (Blackwell Publishing Ltd, 2008)
      Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, ...
    • A New Metric for Detecting Change in Slowly Evolving Brain Tumors: Validation in Meningioma Patients 

      Pohl, Kilian M; Konukoglu, Ender; Novellas, Sebastian; Ayache, Nicholas; Fedorov, Andriy; Talos, Ion-Florin; Golby, Alexandra Jacqueline; Wells, William Mercer; Kikinis, Ron; Black, Peter McLaren (Oxford University Press (OUP), 2011)
      BACKGROUND: Change detection is a critical component in the diagnosis and monitoring of many slowly evolving pathologies. OBJECTIVE: This article describes a semiautomatic monitoring approach using longitudinal medical ...
    • Outcomes after discontinuation of antiepileptic drugs after surgery in patients with low grade brain tumors and meningiomas 

      Das, Rohit R.; Artsy, Elinor; Hurwitz, Shelley; Wen, Patrick Yung Chih; Black, Peter McLaren; Golby, Alexandra Jacqueline; Dworetzky, Barbara Ann; Lee, Jong Woo (Springer Nature, 2012)
      Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. ...
    • A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis 

      Alvarez, James V.; Mukherjee, Neelanjan; Chakravarti, Arnab; Robe, Pierre; Zhai, Gary; Chakladar, Abhijit; Loeffler, Jay S; Black, Peter McLaren; Frank, David A. (Libertas Academica, 2007)
      Gliomas frequently display constitutive activation of the transcription factor STAT3, a protein that is known to be able to mediate neoplastic transformation. STAT3 regulates genes that play a central role in cellular ...